**Meet the editors**

Cristina Manuela Drăgoi is a pharmacist and associate professor at the Department of Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania. She has professional experience in oxidative stress mechanisms, assessing drugs' effects on biochemical markers, and identifying predictive biomarkers for metabolic diseases. Her scientific re-

search focuses on revealing melatonin actions on major physiological and pathological processes, determining its modulatory abilities on different stages of fetus evolution, on healthy aging mechanisms, and on assessing indole derivatives interactions with DNA, performing studies on different animal models and cell lines. This captivating subject of applied biochemistry in drug research is the core of her scientific projects, a fact depicted also by her authorship of several books and book chapters on the pharmacological features of melatonin and its biosynthesis precursors.

Alina Crenguța Nicolae is an associate professor at the Department of Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Carol Davila", Bucharest, Romania. Her scientific research projects are in the field of neuropharmacology, focusing on the individual neurobiochemical profile, correlated with age, gender, race, metabolic and genetic profiles, as well

as the establishment of predictive biomarkers that trigger the response to pharmacotherapy and multidrug resistance mechanisms modulation at the level of the blood–brain barrier. Mrs. Nicolae's scientific research is supported by many articles published in ISI journals, and books and book chapters on the biochemical mechanisms underlying the vast and intricate process of multidrug resistence that occurs in living cells.

Contents

**Preface VII**

**and Trends 13** Jean A. Boutin

**Biochemical Approach 59** Aysun Hacışevki and Burcu Baba

**Lipid Peroxidation 105**

**and Its Metabolites 121**

Mohammad Khazaie

Hanan Farouk Aly and Maha Zaki Rizk

**Section 1 Molecular Biochemistry and Pharmacological Mechanisms of Action of Melatonin and Its Indole Derivatives 1**

Chapter 1 **Introductory Chapter: Melatonin, the Integrative Molecule**

Chapter 2 **How Can Molecular Pharmacology Help Understand the**

Chapter 3 **An Overview of Melatonin as an Antioxidant Molecule: A**

Chapter 4 **Melatonin and Its Indisputable Effects on the Health State 87**

Chapter 5 **Melatonin and Exercise: Their Effects on Malondialdehyde and**

**Section 2 Clinical Approaches and Health State Modulation by Melatonin**

Chapter 6 **Melatonin in Childhood Epilepsy and in Child Neurology 123** Justyna Paprocka, Marek Kijonka and Maria Sokół

Mahsa Rastegar Moghaddam Mansouri, Sadegh Abbasian and

Cristina Manuela Drăgoi and Alina Crenguța Nicolae

**Multiple Actions of Melatonin: 20 Years of Research**

**within the Human Architecture 3**
