**Solitary Plasmacytoma of Bone**

Jianru Xiao, Wending Huang, Xinghai Yang and Honglin Teng *The Second Military Medical University China* 

#### **1. Introduction**

Solitary plasmacytoma (SP), histologically indistinguishable from multiple myeloma (MM), is a kind of malignant tumor characterized by the proliferation of monoclonal plasma cells. SP is an independent subtype of plasmacytoma, including extramedullary plasmacytoma and solitary plasmacytoma of bone (SPB) [1]. Most solitary plasmacytomas progress to MM, and are usually treated in the department of hematology. SPB may involve in any bone, however, it mainly occurs in the axial skeleton, especially in a vertebra. SPB has a high risk of progression to MM, and on magnetic resonance imaging (MRI) examination, at least 25% of patients with an apparent solitary lesion have evidence of disease elsewhere.

In patients with solitary plasmacytoma of bone, the diagnosis can be made in the light of clinical and radiographic manifestations combined pathology. Thereafter, systemic treatment should be performed according to the status of the patients and the evidence of disease progression [2-6].

Although definitive local radiotherapy is a choice for the treatment of SPB, no affirmative conclusion can be drawn due to the lack of randomized trials for this kind of disease. Surgical management is usually non-mandatory; however, patients may require decompression or reconstruction if there are spinal cord compression and pathological fracture.

#### **2. Epidemiology and clinical features**

SPB is a primary malignant tumor, mainly affecting axial skeleton, especially the vertebra[2]. These tumors occur in the spine twice as often as other bony sites [7]. The male/female ratio of SPB is about 2 to 1 with a mean age of 55 years [2]. Solitary plasmacytoma is one of the most common malignant primary tumors in spine. Involvement of the base of the skull may present with cranial nerve palsies. The early symptoms of SPB are not typical. The most common presenting symptom is pain. If spine is involved, deformity, motor deficits, sensory deficits, n bowel and bladder dysfunction could be seen as well as pain as result of epidural spinal-cord compression and/or instability of the vertebra. Plain radiography shows expansile, irregular osteolytic lesions with or without vertebra instability [8-9]. CT or MRI can detect the lesions and describe the tumor extent at an earlier stage. Particularly, MRI scanning has an important reference value in description of residual tumor, local relapse

Solitary Plasmacytoma of Bone 179

Fig. 1. A 68-year-old man with SBP of T10. Lateral radiograph showing mild collapse of vertebral body height at T10 (A).Computed tomography scan showing lytic bone

T1-weighted imaging(C) and hyperintense on T2-weighted imaging(D), and bright

aspiration biopsy is necessary to establish the diagnosis of SBP or MM with certainty.

enhancement after administration of gadolinium(E).

The followings are the recommended diagnostic criteria [3]:

2. Histologically normal marrow aspirate and trephine.

6. No additional lesions on MRI scan of the spine.

1. A single area of bone damage due to clonal plasma cell hyperplasia.

3. Normal results on skeletal survey, including radiology of long bones.

4. No anemia, hypercalcemia, or renal impairment due to plasma cell dyscrasia.

5. Absent or low serum or urinary level of monoclonal immunoglobulin (level of >20g/L

Biopsy and histopathologic examination play an important role in diagnosing this disease. SPB is generally diagnosed by pathology. Needle biopsy under CT or fluoroscopy guidance

**4. Diagnosis** 

**4.1 Diagnostic criteria** 

suspicious of MM).

**4.2 Biopsy and pathology** 

destruction of the vertebral body (B). Magnetic resonance imaging showing hypointense on

If SBP is suspected, the following laboratory investigations should be performed in all patients: complete blood count (CBC), electrolytes, immunoglobulin, serum monoclonal paraprotein (M protein) electrophoresis, urine protein electrophoresis and immune fixation, marrow cell morphology and marrow aspiration biopsy. The prevalence of a monoclonal protein (M protein) in the serum or urine of patients with SBP varies from 24% to 72%, and the levels of the M protein(<3g/dl) are lower than those patients with MM [2]. In our experience, marrow

and progression to MM after treatment [10]. The presence of M protein has been reported in 24%-72% of patients [2].

#### **3. Radiological and laboratory features**

All patients with suspected solitary plasmacytoma should undergo X-ray examination, computed tomography (CT) scan or magnetic resonance imaging (MRI). Plain radiographs showed solitary expansile osteolytic lesion with or without collapse of the vertebral body (Fig.A). However, plain radiographs did not show any abnormality in some patients when the disease was in the early stage, thus CT scan or CT three-dimensional reconstruction examinations were needed. Most CT scan showed osteolytic lesions with or without collapse of the vertebral body or even paravertebral soft tissue masses (Fig.B). As a noninvasive technique for detecting a potential lesion of the bone, MRI has been a routine evaluation. However, there are no definitive guidelines to verify the involvement on an MRI examination. Generally, MRI shows Low or intermediate signal on T1-weighted imaging and hyperintense on T2-weighted imaging, and significant enhancement with gadolinium (Fig.C-E). Whole-body MRI may be an effective technique to detect multiple lesions but costly. MRI patterns of marrow involvement play an important role in assessment myeloma bone disease. They include normal appearance of bone marrow despite minor microscopic plasma cell infiltration, focal involvement, homogeneous diffuse infiltration, combined diffuse and focal infiltration, and variegated or "salt-and-pepper" pattern with inhomogeneous bone marrow with interposition of fat islands. It is essential to have investigations of full skeletal survey to rule out multiple lesions. It is well-known that emission computed tomography (ECT) has a primary value in detecting multiple lesions of bone. Therefore, it is recommended for patients' suspicion of multiple myeloma to undergo ECT scan, but the positive incidence of detecting occult disease is not encouraging. With the advent of positron emission tomography/computed tomography (PET-CT)[11-12], it is proved to be an important method to detect occult lesions.

and progression to MM after treatment [10]. The presence of M protein has been reported in

All patients with suspected solitary plasmacytoma should undergo X-ray examination, computed tomography (CT) scan or magnetic resonance imaging (MRI). Plain radiographs showed solitary expansile osteolytic lesion with or without collapse of the vertebral body (Fig.A). However, plain radiographs did not show any abnormality in some patients when the disease was in the early stage, thus CT scan or CT three-dimensional reconstruction examinations were needed. Most CT scan showed osteolytic lesions with or without collapse of the vertebral body or even paravertebral soft tissue masses (Fig.B). As a noninvasive technique for detecting a potential lesion of the bone, MRI has been a routine evaluation. However, there are no definitive guidelines to verify the involvement on an MRI examination. Generally, MRI shows Low or intermediate signal on T1-weighted imaging and hyperintense on T2-weighted imaging, and significant enhancement with gadolinium (Fig.C-E). Whole-body MRI may be an effective technique to detect multiple lesions but costly. MRI patterns of marrow involvement play an important role in assessment myeloma bone disease. They include normal appearance of bone marrow despite minor microscopic plasma cell infiltration, focal involvement, homogeneous diffuse infiltration, combined diffuse and focal infiltration, and variegated or "salt-and-pepper" pattern with inhomogeneous bone marrow with interposition of fat islands. It is essential to have investigations of full skeletal survey to rule out multiple lesions. It is well-known that emission computed tomography (ECT) has a primary value in detecting multiple lesions of bone. Therefore, it is recommended for patients' suspicion of multiple myeloma to undergo ECT scan, but the positive incidence of detecting occult disease is not encouraging. With the advent of positron emission tomography/computed tomography (PET-CT)[11-12], it is

24%-72% of patients [2].

**3. Radiological and laboratory features** 

proved to be an important method to detect occult lesions.

Fig. 1. A 68-year-old man with SBP of T10. Lateral radiograph showing mild collapse of vertebral body height at T10 (A).Computed tomography scan showing lytic bone destruction of the vertebral body (B). Magnetic resonance imaging showing hypointense on T1-weighted imaging(C) and hyperintense on T2-weighted imaging(D), and bright enhancement after administration of gadolinium(E).

If SBP is suspected, the following laboratory investigations should be performed in all patients: complete blood count (CBC), electrolytes, immunoglobulin, serum monoclonal paraprotein (M protein) electrophoresis, urine protein electrophoresis and immune fixation, marrow cell morphology and marrow aspiration biopsy. The prevalence of a monoclonal protein (M protein) in the serum or urine of patients with SBP varies from 24% to 72%, and the levels of the M protein(<3g/dl) are lower than those patients with MM [2]. In our experience, marrow aspiration biopsy is necessary to establish the diagnosis of SBP or MM with certainty.

#### **4. Diagnosis**

#### **4.1 Diagnostic criteria**

The followings are the recommended diagnostic criteria [3]:


#### **4.2 Biopsy and pathology**

Biopsy and histopathologic examination play an important role in diagnosing this disease. SPB is generally diagnosed by pathology. Needle biopsy under CT or fluoroscopy guidance

Solitary Plasmacytoma of Bone 181

the involved spine should be performed [2,8,27]. For extraspinal osseous lesion, definitive local radiotherapy is the main treatment method. However, if pathological fractures of long bones or weight-bearing bones have been detected, surgical resection and fixation may also

If surgery is required, radiotherapy should also be given. However, surgery should be carried out before radiotherapy because surgery may become more difficult in patients with preoperative radiotherapy [2,8,28,29]. Spinal radiation before surgery is associated with a significantly higher rate of major wound complication and may adversely affect the surgical

Although there are insufficient data to support and advocate adjuvant chemotherapy for patients with SBP, it may be appropriate to consider to adjuvant radiotherapy in patients at higher risk of treatment failure [2-5]. Aviles et al [30] performed a prospective study which reported a benefit with combined chemotherapy and RT compared to RT alone. This study concluded that combined radiochemotherapy were likely to increase remission and survival duration. A suggested approach is to follow guidelines for the treatment of multiple myeloma [3]. In addition, patients presenting as SBP, but found on MRI to have more extensive disease, should be considered as having MM and treated accordingly [2,3,6]. In addition, bisphosphonate treatment lasting for at least one year may be benefit for patients with SBP. As for patients with MM, the bisphosphonate treatment should be prolonged to 2 years. Such management can be effective in reducing skeletal-related events [3,31-33].

The general prognosis of SP is comparatively better, with a 5-year survival rate about 70% and median overall survival period of 7.5-12 years [2,3,34]. There is no clear factor to predict prognosis of SP. Some researchers consider the following factors as prognosis [3,5,17,18]: old age, tumor size, and persistence of M protein after treatment. Majority of patients probably developed MM in the end with the median time of 2-4 years, especially those with SP of spine [5,15,16-18], and approximately 15%-45% of patients remain disease free at 10 years[4]. However, there is still no effective method to prevent SPB from progressing to MM and there is no consensus in the literature about these adverse prognostic features. Wilder et al[36]performed a multivariate analysis on prognostic factors in a series of 60 patients and considered sustained M protein for over one year after radiotherapy as the adverse prognostic factor, while age, tumor size and paraprotein level were of no special prognostic value. Modalities for monitoring of disease status such as PET/CT, free light chain examination, marrow aspiration biopsy, etc. could identify high risk groups for disease

For patients with SBP, it is required carefully monitoring to detect progression to MM, possibly 6 weekly for 6 months, with extension of clinic appointments. Assessment of signs and symptoms should be undertaken, together with radiographic and laboratory investigations such as MRI, haematology, biochemistry, serum and urine paraprotein

be required.

outcome [28].

**5.3 Chemotherapy and recommendations** 

**6. Natural history and prognosis** 

progression [3,5,6,11,12].

estimation [2-6,14].

can be safe and effective. As this kind of tumor is rare, it is recommended that pathology review should be performed by a senior histopathologist who is skilled in bone tumor or lymphatic system diseases. In our experience, the definitive diagnosis of SPB should be based on clinical, radiologic, and pathologic findings of patients.

#### **5. Treatment of solitary plasmacytoma of bone**

#### **5.1 Radiotherapy and recommendations**

Radiotherapy is considered the treatment of choice for solitary plasmacytoma of bone. Although high local control rates of 83% to 96% are achieved with moderate doses of radiotherapy, the progression to multiple myeloma is considerably common [6,13-17]. However, the evidence base of radiotherapy is largely consisted of retrospective studies of small series of patients. In addition, data on dose-response relationships are weak in most series of the literatures [3].

On the basis of evidences in the literatures, recommendations were put forward by oncologists [3,5,6]. The recommendation on the dose of radiotherapy is 40Gy in 20 fractions for lesions with a margin of at least 2 centimeters. For lesions of SPB greater than 5 centimeters, a higher dose of up to 50Gy in 25 fractions should be considered. As for the extent of radiation management, the clinical target volume should include the tumor shown on MRI with a margin of at least 2 cm. For a vertebral lesion, the scope of radiotherapy should cover the entire bone involved, together with uninvolved adjacent vertebrae [3,8,18]. For solitary plasmacytoma of spine, considering the anatomical specificity, more exact measurement of radiotherapy dose and target volume is needed to avoid unnecessary irritation or damage of normal tissues and neurological elements. It should include the whole involved vertebra, together with one uninvolved vertebra above and below.

#### **5.2 Surgery and recommendations**

Surgery is not the first choice to treat solitary plasmacytoma of bone. However, it remains a reliable option for patients with intractable pain as a result of the vertebral involvement, vertebral instability, neurological compromise, or a combination of these disorders [3,8,9,19]. It is the only method that leads to immediate relief of spinal compression and direct biomechanical stabilization of the involved vertebra. Indications for surgery include [3,8,9,19,20]: any patient with an unstable of spine where surgery is the only way to fix and reconstruct the stabilization of spine; malignant spinal cord compression which can be alleviated by surgery; direct compression by intraspinal bony fragments; existing or impending motor dysfunction for which immediate decompression is required; no response to radiotherapy or radiotherapy tolerance and disease progressing.

The choice of surgical methods depends on the site and extent of the tumor, general condition of each patient, as well as skills and experience of surgeons. It is required that surgical plan should be designed carefully before procedure [21,22]. A gross-total resection is a reasonable choice for cervical spine tumor [23], and total en-bloc resection is feasible but challenging [22,24]. However, total en-bloc spondylectomy or resection is ideal for lesions in thoracic and lumbar spine and extraspinal involvements [22,24-26]. Given to the probability of long-term survival in patients with this disease, it is recommended that reconstruction of

can be safe and effective. As this kind of tumor is rare, it is recommended that pathology review should be performed by a senior histopathologist who is skilled in bone tumor or lymphatic system diseases. In our experience, the definitive diagnosis of SPB should be

Radiotherapy is considered the treatment of choice for solitary plasmacytoma of bone. Although high local control rates of 83% to 96% are achieved with moderate doses of radiotherapy, the progression to multiple myeloma is considerably common [6,13-17]. However, the evidence base of radiotherapy is largely consisted of retrospective studies of small series of patients. In addition, data on dose-response relationships are weak in most

On the basis of evidences in the literatures, recommendations were put forward by oncologists [3,5,6]. The recommendation on the dose of radiotherapy is 40Gy in 20 fractions for lesions with a margin of at least 2 centimeters. For lesions of SPB greater than 5 centimeters, a higher dose of up to 50Gy in 25 fractions should be considered. As for the extent of radiation management, the clinical target volume should include the tumor shown on MRI with a margin of at least 2 cm. For a vertebral lesion, the scope of radiotherapy should cover the entire bone involved, together with uninvolved adjacent vertebrae [3,8,18]. For solitary plasmacytoma of spine, considering the anatomical specificity, more exact measurement of radiotherapy dose and target volume is needed to avoid unnecessary irritation or damage of normal tissues and neurological elements. It should include the

whole involved vertebra, together with one uninvolved vertebra above and below.

to radiotherapy or radiotherapy tolerance and disease progressing.

Surgery is not the first choice to treat solitary plasmacytoma of bone. However, it remains a reliable option for patients with intractable pain as a result of the vertebral involvement, vertebral instability, neurological compromise, or a combination of these disorders [3,8,9,19]. It is the only method that leads to immediate relief of spinal compression and direct biomechanical stabilization of the involved vertebra. Indications for surgery include [3,8,9,19,20]: any patient with an unstable of spine where surgery is the only way to fix and reconstruct the stabilization of spine; malignant spinal cord compression which can be alleviated by surgery; direct compression by intraspinal bony fragments; existing or impending motor dysfunction for which immediate decompression is required; no response

The choice of surgical methods depends on the site and extent of the tumor, general condition of each patient, as well as skills and experience of surgeons. It is required that surgical plan should be designed carefully before procedure [21,22]. A gross-total resection is a reasonable choice for cervical spine tumor [23], and total en-bloc resection is feasible but challenging [22,24]. However, total en-bloc spondylectomy or resection is ideal for lesions in thoracic and lumbar spine and extraspinal involvements [22,24-26]. Given to the probability of long-term survival in patients with this disease, it is recommended that reconstruction of

based on clinical, radiologic, and pathologic findings of patients.

**5. Treatment of solitary plasmacytoma of bone** 

**5.1 Radiotherapy and recommendations** 

series of the literatures [3].

**5.2 Surgery and recommendations** 

the involved spine should be performed [2,8,27]. For extraspinal osseous lesion, definitive local radiotherapy is the main treatment method. However, if pathological fractures of long bones or weight-bearing bones have been detected, surgical resection and fixation may also be required.

If surgery is required, radiotherapy should also be given. However, surgery should be carried out before radiotherapy because surgery may become more difficult in patients with preoperative radiotherapy [2,8,28,29]. Spinal radiation before surgery is associated with a significantly higher rate of major wound complication and may adversely affect the surgical outcome [28].

#### **5.3 Chemotherapy and recommendations**

Although there are insufficient data to support and advocate adjuvant chemotherapy for patients with SBP, it may be appropriate to consider to adjuvant radiotherapy in patients at higher risk of treatment failure [2-5]. Aviles et al [30] performed a prospective study which reported a benefit with combined chemotherapy and RT compared to RT alone. This study concluded that combined radiochemotherapy were likely to increase remission and survival duration. A suggested approach is to follow guidelines for the treatment of multiple myeloma [3]. In addition, patients presenting as SBP, but found on MRI to have more extensive disease, should be considered as having MM and treated accordingly [2,3,6]. In addition, bisphosphonate treatment lasting for at least one year may be benefit for patients with SBP. As for patients with MM, the bisphosphonate treatment should be prolonged to 2 years. Such management can be effective in reducing skeletal-related events [3,31-33].

#### **6. Natural history and prognosis**

The general prognosis of SP is comparatively better, with a 5-year survival rate about 70% and median overall survival period of 7.5-12 years [2,3,34]. There is no clear factor to predict prognosis of SP. Some researchers consider the following factors as prognosis [3,5,17,18]: old age, tumor size, and persistence of M protein after treatment. Majority of patients probably developed MM in the end with the median time of 2-4 years, especially those with SP of spine [5,15,16-18], and approximately 15%-45% of patients remain disease free at 10 years[4].

However, there is still no effective method to prevent SPB from progressing to MM and there is no consensus in the literature about these adverse prognostic features. Wilder et al[36]performed a multivariate analysis on prognostic factors in a series of 60 patients and considered sustained M protein for over one year after radiotherapy as the adverse prognostic factor, while age, tumor size and paraprotein level were of no special prognostic value. Modalities for monitoring of disease status such as PET/CT, free light chain examination, marrow aspiration biopsy, etc. could identify high risk groups for disease progression [3,5,6,11,12].

For patients with SBP, it is required carefully monitoring to detect progression to MM, possibly 6 weekly for 6 months, with extension of clinic appointments. Assessment of signs and symptoms should be undertaken, together with radiographic and laboratory investigations such as MRI, haematology, biochemistry, serum and urine paraprotein estimation [2-6,14].

Solitary Plasmacytoma of Bone 183

[17] Tsang RW, Gospodarowicz MK, Pintilie M, et al. Solitary plasmacytoma treated with

[18] Mayr NA, Wen BC, Hussey DH, et al. The role of radiation therapy in the treatment of

[19] Rao G, Ha CS, Chakrabartl I, et al. Multiple myeloma of the cervical spine: treatment strategies for pain and spinal instability. J Neurosurg Spine 2006;5:140–145. [20] Patchell RA, Tibbs PA, Regine WF, et al. Direct decompressive surgical resection in the

[21] Boriani S,Weinstein JN,Biagini R. Primary bone tumors of the spine.Terminology and

[22] Yamazaki T, McLoughlin GS, Patel S, Rhines LD, Fourney DR.Feasibility and safety of

[23] Barrenechea IJ,Perin NI, Triana A,et al.Surgical management of chordomas of the

[24] Currier BL, Papagelopoulos PJ, Krauss WE, Unni KK, Yaszemski MJ.Total en bloc spondylectomy of C5 vertebra for chordoma. Spine 2007;32:E294-299. [25] Tomita K, Kawahara N, Baba H, Tsuchiya H, Fujita T, Toribatake Y. Total en bloc

[26] Kawahara N, Tomita K, Murakami H, Demura S. Total en bloc spondylectomy for

[27] McLain RF, Weinstein JN. Solitary plasmacytomas of the spine: a review of 84 cases. J

[28] Ghogawala Z,Mansfield FL, Borges LF. Spinal radiation before surgical decompression

[29] Chataigner H,Onimus M,Polette A. Surgical treatment of myeloma localized in the

[30] Aviles A, Huerta-Guzman J, Delgado S, Fernadez A, Diaz-Maqueo JC: Improved

[31] Kyle RA, Yee GC, Somerfield MR,et al. American Society of Clinical Oncology 2007

[32] Berenson JR, Rosen LS, Howell A, et al. Zoledronic acid reduces skeletal-related events

[33] Terpos E, Moulopoulos LA, Dimopoulos MA. Advances in imaging and the management of myeloma bone disease. J Clin Oncol 2011; 29:1907-1915. [34] Dimopoulos MA, Hamilos G. Solitary bone plasmacytoma and extramedullary

in patients with osteolytic metastastes. Cancer 2001;91:1991-1200.

plasmacytoma. Curr Treat Options Oncol 2002;3:255-259.

solitary plasmacytomas. Radiother Oncol 1990;17:293-303

2001;50:113-120

trial. Lancet 2005;366:643-648.

Spine 1997;22:324-333.

Spinal Disord 1989;2:69-74.

compression. Spine 2001;26:818-821.

myeloma. J Clin Oncol 2007;25:2464-2472.

spine. Rev Chir Reparatrice Appar Mot 1998;84:31-38.

Am 2009;40:47-63.

1996, 14:111-117.

surgical staging. Spine 1997;22:1036-1044.

Oncology Study Group. Spine 2009; 34:S31-38.

cervical spine. J Neurosurg Spine 2007;6:398-406.

radiotherapy: impact of tumor size on outcome. Int J Radiat Oncol Biol Phys

treatment of spinal cord compression caused by metastatic cancer: a randomized

en bloc resection for primary spine tumors: a systematic review by the Spine

spondylectomy. A new surgical technique for primary malignant vertebral tumors.

spinal tumors: surgical techniques and related basic background.Orthop Clin North

adversely affects outcomes of surgery for symptomatic metastatic spinal cord

outcome in solitary bone plasmacytoma with combined therapy. *Hematol Oncol* 

clinical practice guideline update on the role of bisphosphonates in multiple

#### **7. References**


[1] Fletcher CDM, Unni KK, Mertens F. World Health Organization classification of

[2] Dimopoulos MA, Moulopoulos LA, Maniatis A, et al. Solitary plasmacytoma of bone

[3] Soutar R, Lucraft H, Jackson G. Guidelines on the diagnosis and management of

[4] Weber DM. Solitary Bone and Extramedullary Plasmacytoma. Hematology 2005:373-

[5] Ozsahin M, Tsang RW, Poortmans P, et al. Outcomes and patterns of failure in solitary

[6] Reed V, Shah J, Medeiros LJ, et al. Solitary plasmacytomas: Outcome and prognostic factors after definitive radiation therapy. Cancer. 2011 117:4468-4474. [7] Chang MY, Shih LY, Dunn P, Leung WM, Chen WJ. Solitary plasmacytomas of bone. J

[8] Huang W, Cao D, Ma J, et al. Solitary plasmacytoma of cervical spine: treatment and

[9] Baba1 H, Maezawa1 Y, Furusawa1 N, et al. Solitary plasmacytoma of the

[10] Moulopoulos LA, Dimopoulos MA, Weber D, et al. Magnetic resonance imaging

[11] Adam Z, Bolcak K, Stanicek J, et al. Fluorodeoxyglucose positron emission tomography

[12] Orchard K, Barrington S, Buscombe J, Hilson A, Prentice HG, Mehta A. Fluoro-

[13] Hu K, Yahalom J. Radiotherapy in the management of plasma cell tumors. Oncology

[14] Holland J, Trenkner DA, Wasserman TH, Fineberg BI. Plasmacytoma. Treatment results

[15] Bolek TW, Marcus RB, Mendenhall NP. Solitary plasmacytoma of bone and soft tissue.

[16] Liebross RH, Ha CS, Cox JD, et al. Solitary bone plasmacytoma: outcome and

prognostic factors following radiotherapy. Int J Radiat Oncol Biol Phys 1998;

disease in multiple myeloma. Br J Haematol 2002; 117:133-135.

and conversion to myeloma. Cancer 1992;69: 1513-1517.

Int J Radiat Oncol Biol Phys 1996;36:329-333.

unknown significance. Neoplasma 2007;54:536-540

and asymptomatic multiple myeloma. Blood 2000;96:2037-2044

tumours[A]. Pathology and genetics of tumours of soft tissue and bone[M]. Lyon:

solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. Clin

plasmacytoma: a multicenter Rare Cancer Network study of 258 patients. Int J

prognosis in patients with neurological lesions and spinal instability. Spine,

spine associated with neurological complications. Spinal Cord 1998; 36, 470 -

in the staging of solitary plasmacytoma of bone. J Clin Oncol, 1993; 11:1311-

in multiple myeloma, solitary plasmocytoma and monoclonal gammapathy of

deoxyglucose positron emission tomography imaging for the detection of occult

**7. References** 

376.

475

1315

IARC Press 2002;226-376

Oncol 2004;16:405-413

2010;35:E278-284.

2000;14:101-108

41:1063-1067

Radiat Oncol Biol Phys 2006;64:210-217

Formos Med Assoc 1994;93:397-402.


**10** 

**Plasmacytoma** 

*Russian Federation* 

**Solitary Bone and Extramedullary** 

*Saint Petersburg State Medical University n. a. I.P.Pavlov* 

Galina Salogub, Ekaterina Lokhmatova and Sergey Sozin

Plasmacytomas are clonal proliferations of plasma cells that are cytologically and immunophenotypically identical to those of plasma cell myeloma, but manifest a localized

Solitary plasmacytomas are tumors of plasma cell origin that constitute less than 10% of all plasma cell neoplasms (Osserman, 1959) with a slightly lower median age of approximately

The World Health Organization classification recognizes solitary plasmacytoma of bone (solitary bone plasmacytoma, SBP) and extramedullary / extraosseous plasmacytoma (EMP)

The International Myeloma Working Group (IMWG) recognizes solitary plasmacytoma of bone, extramedullary plasmacytoma and multiple solitary plasmacytomas (+/-recurrent) as distinct entities (The International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the

Solitary bone plasmacytoma has a male:female ratio of 2:1, with a median age of 55 years and primarily affects the axial skeleton especially the vertebrae (Dimopoulos et al, 2000) (Table 1). Osseous lesions constitute approximately 70% of all plasmacytomas. They involve primarily marrow-containing bones, with a predilection for the vertebrae, femurs, and

Malignant bone tumours of the spine are extremely rare (<0,05% of primary neoplasms). Solitary plasmacytoma is the commonest separate entity within this group, accounting for approximately 30% of the total (McLain & Weinstein, 1989). These tumours occur in the

The most common presenting symptom is pain due to bone destruction, but patients with vertebral involvement may also have evidence of spinal cord or nerve root compression.

osseous or extraosseous growth pattern (Jaffe et al., 2001).

**1. Introduction** 

(Jaffe et al., 2001).

63 years (Hernandez et al., 1995).

International Myeloma Working Group, 2003).

**2.1 Epidemiology and clinically-laboratory features** 

spine twice as often as other bony sites (Chang et al, 1994).

**2. Solitary bone plasmacytoma** 

pelvis (Bolek et al., 1996).

[35] Wilder RB, Ha CS, Cox JD, et al. Persistence of myeloma protein for more than one year after radiotherapy is an adverse prognostic factor in solitary plasmacytoma of bone. Cancer 2002; 94:1532-1537.
