**5. Conclusions**

In this chapter, the fiber probe has been demonstrated to conduct the multifunctional manipulation of cell chains, including the sequential organization, precise regulation, and bidirectional transportation. Besides, the dynamic rotation and deformation of the human red blood cell were also realized using the fiber probes. With the advantage of ease integration, high flexibility, and noninvasive, the proposed technique can provide a great perspective in the investigation of the endocytosis and exocytosis purpose. The targeted cells and pathogenic bacterium can be dynamically manipulated simultaneously, which is anticipated to be useful in

**21**

**Author details**

Xiaoshuai Liu and Yao Zhang\*

provided the original work is properly cited.

*Optical Fiber Probe-Based Manipulation of Cells DOI: http://dx.doi.org/10.5772/intechopen.81423*

Guangdong Province (No. 2018A030310501).

The authors declare no competing financial interests.

pathway, and pathogenic process.

**Acknowledgements**

**Conflict of interest**

the analysis, diagnosis, and treatment of cell diseases. By incorporating the FPs into lap-on-chip platforms, the presented technique is expected to enable a new opportunity for the investigation of the nanomedicine injection, intracellular signaling

This work was supported by the National Natural Science Foundation of China (No. 11774135, 11874183, and 61827822), the Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program (No. 2015TQ01X267), the Fundamental Research Funds for the Central Universities (No. 21618301), and the PhD Start-up Fund of Natural Science Foundation of

© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

Institute of Nanophotonics, Jinan University, Guangzhou, China

\*Address all correspondence to: zhyao5@jnu.edu.cn

*Optical Fiber Probe-Based Manipulation of Cells DOI: http://dx.doi.org/10.5772/intechopen.81423*

the analysis, diagnosis, and treatment of cell diseases. By incorporating the FPs into lap-on-chip platforms, the presented technique is expected to enable a new opportunity for the investigation of the nanomedicine injection, intracellular signaling pathway, and pathogenic process.
