**9. Antiadenovirals**

As mentioned above, adenoviruses are unsusceptible to interferons. The acyclic nucleoside phosphonates HPMPC (cidofovir) [26] exhibit antiadenoviral activity. However, these substances are toxic, so they are applied locally in the form of ointments or by injection directly into the affected organ. The target of HPMPC is adenoviral DNA polymerase. The mechanism of the antiviral effect of this compound is based on its phosphorylation by cell kinases and in the synthesis of DNA by competition with conventional nucleosides. At consecutive inclusion in a thread of two molecules of HPMPC, elongation is blocked. The targeted effect of NM on infected cells is provided by a higher affinity of HPMPC diphosphate for viral DNA polymerase than for host DNA polymerase.
