**Preface XI**


Shakti Singh, Rakesh Kumar and Babita Agrawal

Preface

can grow well in cell culture.

care system doctors.

of this work.

Adenovirus infection is a disease of the group of acute respiratory viral infections and is characterized by lesions of the mucous membranes of the upper respiratory tract, conjuncti‐ va, and lymphoid tissue. Adenovirus infection is characterized by widespread prevalence: up to 10% of all human viral diseases account for these viruses. The greatest susceptibility to adenoviruses is demonstrated by children from 6 months to 5 years. In some cases, there is a long persistence of adenoviruses in the human body and the transition to a chronic form of infection. A number of serotypes of adenoviruses induce tumors in animals. Adenovirus in‐ fection is especially dangerous for persons with immunodeficiency, including AIDS patients and recipients of bone marrow and internal organs, in whom adenoviruses cause severe generalized infection. At the same time, adenoviruses are considered to be one of the most studied models of oncolytic viruses and viral vectors, since these DNA-containing viruses are convenient for genetic engineering manipulations, are relatively low pathogenically, and

This book includes a series of articles that highlight a number of issues of human and animal adenoviruses, progress in approaches to the chemotherapy of adenoviral infections, as well as advances in the development of vector vaccines and adenovirus-based gene therapy.

I hope that this book will stimulate additional interest in this field of research and will be useful not only for researchers, students, and clinical interns, but also for practicing health‐

I would like to thank all the excellent authors who participated in the writing of this collec‐ tion of chapters, as well as my students and members of my family who provided me with invaluable support while preparing this book. I also express appreciation to the prominent team of publishers for their clear and well-coordinated activities and assistance at all stages

Federal State Budgetary Scientific Institution "Institute of Experimental Medicine"

**Prof. Dr. Yulia Desheva**

Saint Petersburg, Russian Federation

Saint Petersburg State University Saint Petersburg, Russian Federation
