**Author details**

Victor D. Martinez1,6,†\*, Adam P. Sage1,6,†, Erin A. Marshall1,6, Miwa Suzuki1 , Aaron A. Goodarzi2,3,6, Graham Dellaire4,5,6 and Wan L. Lam1,6

1 Department of Integrative Oncology, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

2 Department of Biochemistry & Molecular Biology, Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

3 Department Oncology, Robson DNA Science Centre, Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

4 Department of Pathology, University of Dalhousie, Halifax, Nova Scotia, Canada

5 Department of Biochemistry & Molecular Biology, University of Dalhousie, Halifax, Nova Scotia, Canada

6 Canadian Environmental Exposures in Cancer (CE2C) Network, Dalhousie University, Halifax, Nova Scotia, Canada

† These authors contributed equally to this work.

\*Address all correspondence to: vmartinez@bccrc.ca

© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**87**

*Oncogenetics of Lung Cancer Induced by Environmental Carcinogens*

[10] Huang SX et al. Role of mutagenicity in asbestos fiberinduced carcinogenicity and other diseases. Journal of Toxicology and Environmental Health. Part B, Critical

Reviews. 2011;**14**(1-4):179-245

fs291/en/ [cited 2018]

[11] World Health Organization. Radon and Health. Geneva, Switzerland: WHO; 2016. Available from: http:// www.who.int/mediacentre/factsheets/

[12] Naujokas MF et al. The broad scope of health effects from chronic arsenic exposure: Update on a worldwide public health problem. Environmental Health Perspectives. 2013;**121**(3):295-302

[13] Lin S et al. A novel S-adenosyl-L-methionine: Arsenic(III)

[14] Ren X et al. An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis. Environmental Health Perspectives.

[15] Hubaux R et al. Molecular features in arsenic-induced lung tumors. Molecular Cancer. 2013;**12**:20

[16] Reichard JF, Puga A. Effects of arsenic exposure on DNA methylation and epigenetic gene regulation. Epigenomics. 2010;**2**(1):87-104

[17] Howe CG et al. Sex-specific associations between onecarbon metabolism indices and posttranslational histone modifications in arsenic-exposed Bangladeshi adults. Cancer Epidemiology, Biomarkers & Prevention. 2017;**26**(2):261-269

[18] Riedmann C et al. Inorganic arsenicinduced cellular transformation is coupled with genome wide changes in

2002;**277**(13):10795-10803

2011;**119**(1):11-19

methyltransferase from rat liver cytosol. The Journal of Biological Chemistry.

*DOI: http://dx.doi.org/10.5772/intechopen.81064*

[1] Global Burden of Disease Cancer. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disabilityadjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA

Oncology. 2017;**3**(4):524-548

2013;**88**(3):494-503

Cancer. 2018;**118**:69-75

2007;**7**(10):778-790

2018;**110**:95-104

2012;**11**:89

[2] Pallis AG, Syrigos KN. Lung cancer in never smokers: Disease characteristics and risk factors. Critical Reviews in Oncology/Hematology.

[3] Shahadin MS et al. Challenges and future direction of molecular research in air pollution-related lung cancers. Lung

[4] Hubaux R et al. Arsenic, asbestos and radon: Emerging players in lung tumorigenesis. Environmental Health.

[5] Sun S, Schiller JH, Gazdar AF. Lung cancer in never smokers—A different disease. Nature Reviews. Cancer.

[6] Stanley FK et al. Comprehensive survey of household radon gas levels and risk factors in southern Alberta. CMAJ Open. 2017;**5**(1):E255-E264

[7] Saint-Jacques N et al. Estimating the risk of bladder and kidney cancer from exposure to low-levels of arsenic in drinking water, Nova Scotia, Canada. Environment International.

[8] Teras LR et al. Residential radon exposure and risk of incident

hematologic malignancies in the cancer prevention study-II nutrition cohort. Environmental Research. 2016;**148**:46-54

[9] World Health Organization Arsenic. 2016. Available from: http://www.who. int/mediacentre/factsheets/fs372/en/

[Accessed: Feb 15, 2017]

**References**

*Oncogenetics of Lung Cancer Induced by Environmental Carcinogens DOI: http://dx.doi.org/10.5772/intechopen.81064*
