**6.6 STAT6**

Opposed to its role in the NFκB pathway, where AIB1 is the unique family member interacting with a kinase, STAT6 solely interacts with SRC-1. However, this does not mean AIB1 does not play a critical role. While SRC-1 directly interacts with STAT6 on the chromatin via its bHLH domain, AIB1 cannot. Recruited p300 bound to STAT6 can then recruit AIB1, which potentiates STAT6 signaling. This represents a unique cooperation between SRC-1 and AIB1, as SRC-1 is required for the co-activation of STAT6, and AIB1 then potentiates the transcription complex's activity. This was found to be an IL-4 dependent interaction, which acts in a dosedependent manner [76–79]. Such interactions are controlled by PP2A, as described in Section 3.2 [80].

We attempted to highlight some of the most categorized interactions between AIB1 and transcription factors that are well studied oncogenes. See **Figure 1** for a more complete list of proteins that interact with AIB1.
