**6.5 NF**κ**B pathway**

Though many binding partners are shared between members of the NCOA family, mostly between SRC-1 and AIB1, cooperation with IKK is unique to AIB1. IKK mediates the degradation of IkB, the inhibitor of NFκB, in response to TNFα stimulation. Interestingly, in parallel to this, AIB1 is phosphorylated by IKK, increasing its nuclear localization and then can act on NFκB bound to DNA through its C-terminal activation domain [11, 75]. This emphasizes the ability of AIB1 to be to play a multi-faceted role within a signaling pathway, and the importance of its regulation to control its potency.
