*4.3.3 Potential candidates*

miRNAs are also involving in radiotherapy responses. The expression of miRNAprocessing enzymes Drosha and Dicer was found to be upregulated in radioresistant cell lines when compared with radiosensitive cell lines [98]. The role of miRNAs in radiotherapy response was evaluated further in the study cited as reference [87]. In the study, biomarkers for the prediction of chemoradiotherapy response in CRC were identified by using integrative and systematic bioinformatics analysis. The unique target genes of miR-198 and miR-765 were altered significantly upon transfection of specific miRNA mimics in the radiosensitive cell line. Thus, it could be said that miR-198, miR-202, miR-371-5p, miR-513a-5p, miR-575, miR-630, and miR-765 could be used for predicting the response of CRC to preoperative chemoradiotherapy [87]. Still, further studies are needed to understand the miRNA role in radiotherapy/radiochemotherapy prediction.
