**Conflict of interest**

None.

**4. Scope and perspectives**

**Figure 1.** Uruguay regionalization according to the land use.

**Active ingredients Recommended average** 

42 Endocrine Disruptors

**dose**

Mancozeb (80%) (F) 3,0 L/ha 27,000 81,000 Mancozeb + metalaxyl (F) 2,5 kg/ha 14,187 35,468 Metolachlor (H) 1,2 L/ha 1,290,000 **1,548,000** S-Metolachlor (90%) (H) 1,2 L/ha 1,290,000 **1,548,000** Tebuconazole (25%) (F) 1,3 L/ha 1,709,400 **2,136,750**

For the estimation, the average dose reported was used. The total sown area corresponds to the sum of the crops in which

the compound is used. The substances are listed in alphabetical order. F-fungicide, H-herbicide, I-insecticide.

**Table 5.** Estimation of formulated applied according to hectares sown in the agricultural year 2016/2017.

**Units Total cultivated area (ha)**

**Estimated AI added (L** 

**or kg)**

The agricultural intensification and expansion are global processes associated with growing worldwide demands (food, feed, fiber and fuel), and these are highly dependent on external additions of nutrients and crop protection compounds [27, 28]. In Uruguay, these processes began from 2000, mainly in the west littoral zone with the inclusion of soybean in agricultural
