Contents

#### **Preface XI**


Gabriela Eguren and Noelia Rivas-Rivera


#### Chapter 8 **Rapid, High-Throughput Detection of Endocrine Disrupting Chemicals Using Autobioluminescent Cellular Bioreporters 127** Tingting Xu, Andrew Kirkpatrick, Jody Toperzer, Marvin Steven

Furches, Steven Ripp, Gary Sayler and Dan Close

Preface

the field of EDCs.

Endocrine-disrupting chemicals (EDCs), including many agents of chemical or natural ori‐ gin, are able to imbalance hormone-driven processes in animals and humans (fish-eating populations). Disruption of maternal endocrine hormones during fetal development may re‐ sult in irreversible consequences in offspring. This book, Endocrine Disruptors, starts with an overview of what endocrine disruptors are, the questions surrounding them, and the ba‐ sis of these chemicals in the ecosystem. The book covers the mechanism of action of bisphe‐ nol S and dibutyl phthalates. This is followed by the biotransformation of bisphenol A and its adverse effects on the next generation. The book also describes the effect of benomyl and its metabolite carbendazim on the reproductive and developmental health and also the role of endocrine disruptors on reproductive toxicity in males. The book offers comprehensive coverage about the communication between the endocrine disruptors and obesity. The final chapter addresses detection of the endocrine-disrupting chemicals using autobiolumines‐ cent cellular bioreporters. This book will be of interest to scientists, neuroendocrinologists, neurotoxicologists, physicians, and lay readers wishing to review recent developments in

Associate Professor of Developmental and Experimental Biology

Division of Anatomy and Embryology

**Ahmed R.G.**

Egypt

Zoology Department Faculty of Science Beni-Suef University
