**3. Future work and recommendations**

OECD takes much effort to promote adverse outcome pathways (AOP) methodology. Androgen receptor-mediated reproductive and developmental toxicity and endocrine disrupting activity would be a novel AOP. It is an approach to support the use of a mode (and/ or mechanism) of action basis for understanding the adverse effects of chemicals and other stressors. AR mediated reproductive and developmental toxicity and endocrine disrupting activity would be a novel future application. Specific molecular signals of AR mediated effects would be the future work.
