**4. The role of STIM1 and ORAI1 on cell signaling**

Given the importance of Ca2+ in many signaling pathways, the impact of STIM1, ORAI, and SOCE on cell signaling is also remarkable. Increasing evidence prove the significant role of this Ca2+ entry pathway in cell physiology and tissue homeostasis, and we focus here on the role of STIM and ORAI proteins on modulators of signaling pathways, such as kinases, phosphatases, and transcription factors. We also describe recent findings that unravel how STIM1 and ORAI1 are modulated by posttranslational modifications.
