Scope of the Series

Modern physiology requires a comprehensive understanding of the integration of tissues and organs throughout the mammalian body, including the expression, structure, and function of molecular and cellular components. While a daunting task, learning is facilitated by our identification of common, effective signaling pathways employed by nature to sustain life. As a main example, the cellular interplay between intracellular Ca2+ increases and changes in plasma membrane potential is integral to coordinating blood flow, governing the exocytosis of neurotransmitters and modulating genetic expression. Further, in this manner, understanding the systemic interplay between the cardiovascular and nervous systems has now become more important than ever as human populations age and mechanisms of cellular oxidative signaling are utilized for sustaining life. Altogether, physiological research enables our identification of clear and precise points of transition from health to development of multi-morbidity during the inevitable aging process (e.g., diabetes, hypertension, chronic kidney disease, heart failure, age-related macular degeneration; cancer). With consideration of all organ systems (e.g., brain, heart, lung, liver; gut, kidney, eye) and the interactions thereof, this Physiology Series will address aims of resolve (1) Aging physiology and progress of chronic diseases (2) Examination of key cellular pathways as they relate to calcium, oxidative stress, and electrical signaling & (3) how changes in plasma membrane produced by lipid peroxidation products affects aging physiology.

Contents

**Preface VII**

**an Answer? 23**

Liliana Ruta

Frances Plane

Angélica Rueda

**Smooth Muscle Cells 65**

Chapter 5 **Calcium Signaling in Prokaryotes 89** Delfina C. Domínguez

Chapter 6 **Role of Calcium in Vomiting 109**

**Section 1 Calcium Signaling in Multiple Cellular Models 1**

Chapter 1 **Regulation of Calcium Signaling by STIM1 and ORAI1 3**

Chapter 2 **Calcium and Cell Response to Heavy Metals: Can Yeast Provide**

Chapter 3 **The Endothelium: The Vascular Information Exchange 43**

Chapter 4 **Mineralocorticoid Receptor in Calcium Handling of Vascular**

**Section 2 Calcium Signaling in Prokaryotic Cell Models 87**

**Section 3 Calcium Signaling and Physiologic Consequences in**

Weixia Zhong and Nissar A. Darmani

**Chemotherapeutic and Cancer Pathology 107**

Francisco Javier Martin-Romero, Carlos Pascual-Caro, Aida Lopez-Guerrero, Noelia Espinosa-Bermejo and Eulalia Pozo-Guisado

Ileana Cornelia Farcasanu, Claudia Valentina Popa and Lavinia

Ran Wei, Stephanie E. Lunn, Stephen L. Gust, Paul M. Kerr and

Rogelio Salazar-Enciso, Nohemi A. Camacho-Concha, Thassio R. Mesquita, Débora Falcón, Jean-Pierre Benitah, Ana M. Gómez and
