**2. Physiological hepatic handling of vitamin E**

The liver is the central organ of vitamin E handling. While intestinal absorption efficiency is similar for all forms of vitamin E [8], the plasma concentrations of vitamin E forms differ a lot (e.g., 22.1 μM for α-TOH vs. 2.2 μM for γ-TOH [9]). The preference of α-TOH in the human body is mediated by several complex and interacting hepatic mechanisms.
