**Meet the editor**

Professor Farid Badria obtained his PhD in Microbial Transformation from the University of Mississippi, USA, and two Masters of Science in Pharmacognosy and Cell Biology from Egypt and the USA. TWAS-ARO- TWAS-ARO in "Public Understanding and Popularization of Science (2013), World Intellectual

Property Organization Gold Medal as the Best Inventor in Egypt (2011), Recognition Outstanding Award in Medicine (Egypt, 2001), Outstanding Arab Scholar, Kuwait (2000), and Khawrazmi Award, Iran (2000), are just some of the awards he has received.

Professor Badria has submitted 43 patents, of which 16 have been granted certificates with intellectual protection for 20 years. With over 200 publications, he continues to lead research projects on developing new therapies for liver disorders, arthritis, and skin disorders, and bomarkers for cancer.

Contents

**Preface VII**

**Resveratrol 1**

**Resveratrol 23**

**and Therapeutic Effects 25**

**Resveratrol and NQO2 79**

**and Age-Related Diseases 117**

Sage Arbor

Chapter 3 **Protective Activity of Resveratrol in Cardio- and Cerebrovascular Diseases 47**

**Section 1 Pharmacology and Therapeutic Applications of**

Chapter 1 **Evaluation of Resveratrol Supplementation on Laboratory Animals, Cats, Pigs, Horses, Dogs, Cattle, and Birds 3** Mary U. Ememe, Anthony K.B. Sackey and Joseph O. Ayo

Chapter 2 **Novel Drug Delivery Systems of Resveratrol to Bioavailability**

Albino Carrizzo, Carmine Izzo and Carmine Vecchione

Tze-chen Hsieh, Barbara B. Doonan and Joseph M. Wu

Chapter 5 **Where and How in the mTOR Pathway Inhibitors Fight Aging: Rapamycin, Resveratrol, and Metformin 93**

Chapter 6 **Resveratrol and SIRT1 Activators for the Treatment of Aging**

Alessandra Stacchiotti, Gaia Favero and Rita Rezzani

Chapter 4 **c-Myc Metabolic Addiction in Cancers Counteracted by**

Poonam Devi, Pratibha Sharma, Charul Rathore and Poonam Negi

**Section 2 Bioavailability, Metabolism, and Mode of Action of**

## Contents

**Preface XI**



Preface

Biomedical research focuses on trying to cure individual diseases and investigate the conse‐ quences of successful treatment by addressing the question: "Do drugs add years to life or add life to years?" Life expectancy has risen in developed countries from about 47 in 1900 to about 80 today, largely due to advances in curing childhood diseases. But those longer lives come with their share of misery. Age-related chronic diseases such as heart disease, cancer,

The standard medical approach—curing one disease at a time—only makes that worse, says Jay Olshansky, a sociologist at the University of Chicago School of Public Health, who runs a project called the Longevity Dividend Initiative, which makes the case for funding aging research to increase the health span of individuals on health and economic grounds. "I would like to see a cure for heart disease or cancer," he says. "But it would lead to a dramat‐

Although science has discovered effective drugs for many of the diseases that afflict man‐ kind, many human health problems remain untreatable. The search for novel therapeutic

This book will describe some aspects of resveratrol (3,5,4′-trihydroxy-trans-stilbene), a stil‐ benoid, a type of natural phenol, and a phytoalexin produced by several plants in response to injury or when the plant is under attack by pathogens such as bacteria or fungi. Even though over 4000 scientific studies have been published on resveratrol and it is used as a dietary supplement, there is no good evidence that consuming resveratrol affects life expect‐

This book addresses in three sections several controversial issues regarding this interesting

This section discusses in detail the pharmacology and effects of resveratrol supplementation

This section presents a novel drug delivery systems for resveratrol, its protective activity in cardio- and cerebrovascular diseases, and where and how in the mTOR pathway inhibitors fight aging. It also investigates resveratrol as an activator for the treatment of aging and age-

natural molecule with fascinating pharmacological and therapeutic effects. **Section 1**: Pharmacology and Therapeutic Applications of Resveratrol

**Section 2**: Bioavailability, Metabolism, and Mode of Action of Resveratrol

stroke, and Alzheimer's are more prevalent than ever.

ic escalation in the prevalence of Alzheimer's disease."

agents is always ongoing.

ancy or human health.

in animals.

related diseases.
