**1. Introduction**

Carbapenems are bactericidal antibiotics often used as a last treatment option for severe infections caused by isolates producing extended-spectrum and/or AmpC β-lactamases. However, their stability to β-lactamases of Gram-negative bacteria is not absolute. From the first report of carbapenemases in the 1980s, the last decade is marked with the rapid spread of carbapenemases-producing organisms, becoming a public health concern worldwide.
