**5. Conclusions**

Endo and exocytosis are well-known mechanisms that regulate signal transduction and the execution of different cellular programs. The number of players, their crosstalk and the networks that they generate is continuously growing adding novel layers of complexity and definition to the current picture.

Intriguingly, increasing evidence shows that signalling itself can control and modulate endocytic pathways (Collinet et al, 2010). Activated receptors elicit a variety of signals that directly or indirectly control endocytosis by several means including phospho-modification of downstream effectors involved in endocytosis, control of protein synthesis and also modulation of actin cytoskeleton dynamics, a process that aids clathrin-mediated endocytosis. This is an emerging view in the trafficking field that will certainly disclose new areas of investigation.
