*Edited by Ivo Nikolaev Sirakov*

The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE – neurotoxicity, loss of antiinflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.

Published in London, UK © 2019 IntechOpen © wacomka / iStock

Prions - Some Physiological and Pathophysiological Aspects

Prions

Some Physiological

and Pathophysiological Aspects

*Edited by Ivo Nikolaev Sirakov*