**Acknowledgements**

This work was supported by the following: Pilot Research Support Program in Tokushima University received by KU; Naito Foundation received by KU; JSPS KAKENHI grant (grant No. 26460557, received by KU; MEXT KAKENHI grant (grant No, 17H05702, received by KU; JSPS KAKENHI grant (grant No. 26293212, received by SS; MEXT KAKENHI grant (grant No, 15H01560 and 17H05701, received by SS; and Practical Research Project for Rare/Intractable Diseases of the Japan Agency for Medical Research and Development (AMED) received by SS.
