**6. Autophagy and damage control**

Cells are equipped with machinery to discard toxic accumulations with a self-cleansing process called macroautophagy. Autophagy of the mitochondria and other cellular debris could rejuvenate cells by disposing defunct organelles, a concept which has been reviewed for AMD. Autophagy may also regulate RPE health by reducing cytotoxicity that is secondary to a primary insult. Future work should address several basic questions about this cell survival mechanism in AMD [21–23].
