**2. Conclusions**

Inherited retinal degenerative diseases are characterized by photoreceptor death that leads to blindness. The underlying genetic causes of these disorders are numerous and diverse, and most involve photoreceptor-specific genes. Zebrafish are amenable to large-scale genetic manipulation and genome editing technology, which as I have illustrated, can generate a great mutant collection. These mutants are helping to uncover molecular mechanisms underlying retinal degeneration disorders. Currently, there are no effective treatments for these diseases in humans to reduce or impede the progression of degeneration; thus, different approaches have been investigated to develop medical interventions for the patients. Zebrafish exhibit extraordinary neuronal regeneration, including retinal photoreceptors, making them an excellent model to develop regenerative therapies to treat photoreceptor degeneration.

## **Acknowledgements**

I thank Steven D. Aird for editing this chapter.
