**6. Discussion**

*Sarcoidosis and Granulomatosis - Diagnosis and Management*

Other suggested treatments for OFG in the literature include hydroxychloroquine [35, 40], methotrexate, clofazimine [35], metronidazole, minocycline [41] alone or in combination with oral prednisone, thalidomide [42, 43], dapsone, and danazol. Surgery may be used in cases that do not respond to medical treatment.

The pattern of onset in orofacial sarcoidosis in patients determines the course and prognosis of the disease and also therapeutic effects after treatment [44],

Altogether, a good prognosis is predicted for OFG.

*Asteroid bodies and multinucleated giant cells in sarcoidosis.*

**6**

**5.5 Prognosis**

**Figure 3.**

**Figure 2.**

*Confluent noncaseating granulomatosis of sarcoidosis.*

OFG is a rare disorder with unknown etiology. As mentioned, there are a variety of causative agents for OFG; but according to the accumulating data, there is no conclusive scientific evidence for the role of genetic susceptibility to the disease in the literature; so in this context, further studies are necessary [49]. Because of histopathological and clinical overlap in oral lesions of granulomatous diseases such as Crohn's disease, sarcoidosis, CG, foreign body granulomas, tuberculosis, etc. [50, 51], there is a controversial question between clinicians and pathologists that whether the formation of granulomas in the oral lesions is a distinct disease or just a feature of a systemic disease. OFG patients should be monitored for all of the symptoms in order to strengthen the possibility of OFG by exclusion of additional symptoms [28].
