*3.2.3 Adverse drug reaction*

After the skin, the liver is a frequent focus of granulomas secondary to drugs. Granulomas associated with adverse drug reactions may be well or poorly formed, but necrosis is very rare. Giant cells may be present, and there is a variable associated inflammatory infiltrate that may include lymphocytes, plasma cells, and eosinophils. There may be associated duct and/or vascular injury. The combination of granulomatous inflammation with significant hepatocellular injury strongly suggests drug-associated liver injury [7].
