**5.5 Biomarkers**

The angiotensin-converting enzyme has been found to be high in 75% of the patients with non-treated sarcoidosis, it does not have much diagnostic value due to its low sensitivity and specificity, and multiple conditions such as diabetes mellitus, tuberculosis, hyperthyroidism, and lung cancer, among other entities, can alter its levels [28]. The measurement of the soluble receptor of interleukin 2 has been proposed as an inflammatory marker in patients with extrapulmonary disease [28]; more studies are needed to assess its use in the clinical setting.
