4. Conclusions

The prevalence of MAR use around the world has been increased over the last years. With a noticeable surge of infertility/subfertility among women of childbearing age, these numbers are expected to remain on the rise. Through this chapter, we evaluated the current state of the literature and showed that MARs have been associated with a number of significant adverse perinatal outcomes, which have repercussions on the child later in life, but also on their parents, and society. MAR-conceived children seem to have poorer health overall with increased healthcare utilization largely due to an increased prevalence of prematurity, being born LBW or SGA, and later in life, being more at risk for behavioral problems, cerebral palsy, and autism among other neurodevelopmental outcomes. Decision makers as well as healthcare professionals should be aware of the repercussions that these methods could have on the mother as well as the child, and appropriately inform mothers and couples seeking these therapies to achieve pregnancy in the context of infertility. Further

stufies are needed to present more evidence to strenghten the findings related to perinatal outcomes when conceiving through MARs.
