6. Titanium prepared platelet-rich fibrin (T-PRF)

Some physicians worry about damage for the patient with glass-evacuated blood collection tubes with silica activators. O'Connell emphasized that silica contact cannot be avoided with glass tubes. These silica particles are dense enough to settle in the sediment and might reach the patient when the product is used during procedures [12]. Recently, Tunali et al. used medical grade titanium tubes to produce titanium prepared platelet-rich fibrin (T-PRF) [10]. This biocompatible material was tried to eliminate the potential negative effects of silica from dry glass or glass-coated plastic tubes [12]. The research showed that T-PRF supply is a more organized network than L-PRF. Furthermore, its fibrin network covers larger area and has thicker fibrin clot. In a human study, wound healing in the palatal mucosa is found better with the T-PRF application [10].
