**Author details**

Surgery. While the available literature is found to be highly-limited, L-PRF *can be* indicated as an innovative *tool* for contemporary oro-maxillo-facial tissue regeneration and bioengineering. Indeed, existing evidence suggests that L-PRF improves early wound healing and promotes post-surgical bone formation/maturation. However, it is noteworthy that a clearer consensus seems to be present regarding its significant beneficial impact on post-surgical pain and discomfort control, regardless the type of procedure. Unlike its predecessors, new L-PRF preparations tend to function more as biologically-active biomaterials and scaffolds for the

Thus, L-PRF should be considered a "living tissue" preparation for natural guided tissue regeneration and not simply a "growth factor-rich" surgical adjuvant. Yet, it is safe to say that this remains an un-explored territory in Dental Biomaterial (Dental Bioengineering) Research,

Our group is currently investigating the potential of incorporating oral-derived mesenchymal stem cells or growth-factor embedded nanoparticles within the L-PRF, as "*super*" or "*smart*" bio-scaffolds, to further boost, with predictability, bone formation, soft tissue healing, treatment time and post-surgical stability, in advanced oro-maxillo-facial surgical procedures

Our research extends to investigate the potential of L-PRF in reducing the need for prescription drugs following invasive surgical procedures such as third molar extraction and cysts

Finally, we are vigorously working on characterizing the rheological and biological variations of L-PRF, alongside partnering up with nurses, physicians and dentists to standardize the

Dr. Nelson Pinto for providing the SEM micrographs and Dr. Macarena Llompart for provid-

The author of this review article declares having no conflict of interest of any form or nature

This work was supported by generous funding and operating grants provided to the BioMAT'X Research Group, part of CIIB (Centro de Investigación e Innovación Biomédica), through

delivery of autologous cells, cytokines and growth factors.

116 Bone Grafting - Recent Advances with Special References to Cranio-Maxillofacial Surgery

such as Periodontally-Accelerated Osteogenic Orthodontics.

preparation protocol, for use in other therapeutic indications.

ing the clinical photographs for L-PRF use in periodontics (**Figure 3B/C**).

with any platelet concentrate product, protocol, technique or company.

in general.

resections.

**Acknowledgements**

**Conflicts of interest**

**Funding**

Ziyad S. Haidar1,2,3,4\*

\*Address all correspondence to: zhaidar@uandes.cl

1 BioMAT'X, Facultad de Odontología, Universidad de los Andes, Santiago, Chile

2 Plan de Mejoramiento Institucional (PMI) en Innovación I+D+i, Universidad de los Andes, Santiago, Chile

3 Programa de Doctorado en BioMedicina, Facultad de Medicina, Universidad de los Andes, Santiago, Chile

4 Centro de Investigación e Innovación Biomédica, Facultad de Medicina, Universidad de los Andes, Santiago, Chile
