**5. Conclusion**

Bone grafting is the most commonly used method for increasing bone regeneration in surgical procedures [52]. More than 2 million bone grafting procedures have been performed worldwide every year. Immediately after blood transfusions, it is the second most common tissue transplant [52]. Important when deciding on the use of bone grafts; patient factors, environmental factors, the experience of the surgeon and the economic dimension of graft use.

Conditions limiting the use of autografts and allografts have accelerated the development of bioceramic technology. As the future of bone grafting procedures, new technologies will emerge in the isolation and production of recombinant human bone morphogenic proteins and growth factors and in the application of autogenous stem cells.
