**Author details**

Marie-Odile Soyer-Gobillard1,2\*, Laura Gaspari3 and Charles Sultan3

1 National Center for Scientific Research (CNRS), Sorbonne University, P. and M. Curie, Paris, France

2 National President of HHORAGES Association (Halt to Artificial Hormones for Pregnancies), The Priory of Baillon, Asnières sur Oise, France

3 Unité d'endocrinologie et de gynécologie pédiatrique, Hôpital Arnaud-de-Villeneuve, CHU de Montpellier, Montpellier, France

\*Address all correspondence to: elido66@orange.fr

© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**19**

*Evidence for Link Between Mental Disorders and in Utero Exposure to Synthetic Hormones…*

neurons. Brain Research Reviews. 2008;**57**(2):363-375. DOI: 10.1016/j. brainresrev.2007.06.010 PMID: 17822775

2004;**199**:142-150

Nature. 1977;**266**:561-562

[10] Kebir O, Krebs MO. Diethylstilbestrol and risk of psychiatric disorders: A critical review and new insights. The World Journal of Biological Psychiatry.

2012;**13**(2):84-95

[8] Newbold RR. Lessons learned from perinatal exposure to diethylstilbestrol. Toxicology and Applied Pharmacology.

[9] Reinisch JM. Prenatal exposure of human foetuses to synthetic progestin and oestrogen affects personality.

[11] Vessey MP, Faiweather DV, Norman-Smith B, Buckley J. A randomized double-blind controlled trial of the value of stilboestrol therapy in pregnancy: long term follow-up of mothers and their offspring. BJOG: An International Journal of Obstetrics & Gynaecology. 1983;**90**:1007-1017

[12] Verdoux H, Ropers J, Costagliola D, Clavel-Chapelon F, Paoletti X. Serious psychiatric outcome of subjects

prenatally exposed to diethylstilbestrol in the E3N cohort study. Psychological

[13] Soyer-Gobillard MO, Sultan C. Behavioral and Somatic Disorders in Children exposed *in utero* to Synthetic Hormones : a Testimony-Case Study in a French Family Troop. In: Magdeldin S, editor. State of the Art of Therapeutic Endocrinology. Niigata University, Japan: InTech; 2012. pp. 67-86

[14] O'Reilly EJ, Mirzaei F, Forman MR, Ascherio A. Diethylstilbestrol exposure in utero and depression in women. American Journal of Epidemiology.

2010;**171**:876-882

Medicine. 2007;**37**:1315-1322

*DOI: http://dx.doi.org/10.5772/intechopen.80969*

[1] Dieckman WJ, Davis ME,

Rynkiewicz LM, Pottinger RE. Does the administration of diethylstilbestrol during pregnancy have therapeutic value? American Journal of Obstetrics and Gynaecology. 1953;**66**:1062-1081

[2] Herbst AL, Ulfelder H, Poskanzer DC. Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. New England Journal of

Medicine. 1971;**284**(15):878-881

[3] Palanza P, Morellini F, Parmigiani S, Vom Saal FS. Prenatal exposure to endocrine disrupting chemicals: effects on behavioral development. Neuroscience and Biobehavioral Reviews. 1999;**23**:1011-1027

[4] Dugard ML, Tremblay-Leveau H, Mellier D, Caston J. Prenatal exposure to ethinylestradiol elicits behavioural abnormalities in the rat. Developmental Brain Research. 2001;**129**:189-199

[5] Arabo A, Lefebvre M, Fermanel M,

[6] Sandner G, Barbosa Silva MJ, Angst J, Knobloch JM, Danion JM. Prenatal exposure of Long-Evans rats to 17alphaethinylestradiol modifies neither latent inhibition nor prepulse inhibition of the statle reflex but elicits minor deficiency in exploratory behaviour. Developmental Brain Research.

[7] Ogiue-Ikeda M, Tanabe N, Mukai H, Hojo Y, Murakami G, Tsurugizawa T, et al. Rapid modulation of synaptic plasticity by estrogens as well as endocrine disrupters in hippocampal

Caston J. Administration of 17-alphaethinylestradiol during pregnancy elicits modifications of maternal behaviour and emotional alteration of the offspring in the rat. Developmental Brain Research.

2005;**156**:93-103

2004;**152**:177-187

**References**

*Evidence for Link Between Mental Disorders and in Utero Exposure to Synthetic Hormones… DOI: http://dx.doi.org/10.5772/intechopen.80969*
