**3. Conclusion**

Vitiligo is a difficult disease to treat because of that new modalities should be investigated. As you known, traditional remedies such as NUVB and topical corticosteroids or tacrolimus did not respond well than new era has developed a concept called targeted phototherapy. Regarded as a targeted phototherapy excimer laser has same wavelength as same as NUVB to focused on apoptosis of T lymphocytes. However, excimer laser is characterized by monochromatic, coherent, and highenergy light, whereas NB-UVB consists of polychromatic, incoherent light with lower intensity. Excimer laser has significant safety profile and got better results than NUVB so that clinicians should decide the option to evaluate cost benefit analysis. Other traditional topical remedies could also apply with excimer laser to induce effectiveness. In segmental vitiligo patients or child population, excimer laser could be treatment of choice also due to localized areas. Another point of view of the laser treatment is ablation. Using the Koebner phenomenon, CO2 laser and ER:YAG have worked as a principle of photothermolysis to moderate skin resurfacing. Traditional remedies could also combine with ablative laser types to increase the absorption of the treatments. Clinicians further to analyze depigmentation need. If patient has more than 80% depigmented areas, Q switch laser combine with topical bleaching creams and sunscreen use, can achieve rapid satisfactory therapeutic outcome in universal vitiligo. Vitiligo does not have a steady all known treatment protocols even though clinicians should further to investigate new combinations.
