**5.1 Imatinib**

Also known as imatinib mesylate, it is used to treat conditions like leukemia and gastrointestinal stromal tumors. It was observed that patients treated with imatinib were reported to develop generalized depigmentation as a side effect. Imatinib is a tyrosinase kinase inhibitor, thus inhibiting the activity of the enzyme, resulting in decreased pigmentation of the skin. The side effects of imatinib include fluid retention, periorbital edema, diarrhea, and myelosuppression. Some of the dermatological side effects include erythroderma, follicular mucinosis, and lichenoid eruption [27].
