*3.4.2 Isotretinoin (Roaccutan\*, Accurane\*)*

Isotretinoin (Roaccutan\*, Accurane\*) synthetic 13 is isomer of tretinoin. It reduces sebaceous gland size and sebum production and inhibits abnormal keratinization. The dose is 0.5–1 mg/kg/24 hours, and the duration of treatment is 4–6 months.

Topical administration of retinoids is not recommended due to the local irritation they cause.

Close attention should be paid to per os administration of retinoids to adolescents due to the teratogenicity they cause and is recommended avoidance of pregnancy for 2 months (isotretinoin) and 3 years (acitretin) at the end of the treatment [72–75].
