**The Role of Cytokines in Orthodontic Tooth Movement**

**The Role of Cytokines in Orthodontic Tooth Movement**

DOI: 10.5772/intechopen.80078

Amila Vujacic, Jasna Pavlovic and Aleksandra Konic-Ristic Amila Vujacic, Jasna Pavlovic and Aleksandra Konic-Ristic

Additional information is available at the end of the chapter Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/intechopen.80078

#### **Abstract**

One of the most important breakthroughs in the understanding of biological features of bones is the explanation of the role of cytokine in reshaping of the bone (remodeling) including the alveolar tooth bone exposed to the effect of the mechanical force during the orthodontic treatment. Since remodeling of the bone initiated by orthodontic forces is connected during its early stage with the inflammation of the surrounding tissue, the assumption was presented about the role of the pro-inflammation cytokine in the process of remodeling of the bone, primarily *IL-1β, IL-б,* and *TNF*. These cytokines are mediators in the reactions of the acute stage of inflammation, as well as in the processes of metabolism, stimulation of resorption, and inhibition of bone creation. In this chapter, we aimed to review the existing knowledge about the roles and dynamics of the change in these three cytokines simultaneously during the early stage of the orthodontic tooth movement.

**Keywords:** orthodontic tooth movement, reshaping of bones, cytokines
