**14. Conclusion and future perspectives**

Dengue viral disease is an emerging health concern in many regions of the world and has become a serious threat in many areas of the world including Southeast Asia and Pakistan. The control of the dengue is difficult as there is no vaccine available so far. Vaccine preparation against dengue requires a tetravalent vaccine but no such licensed compound has been prepared so far. However dengue viral envelope proteins can be targeted to make an effective drug against dengue as these proteins are involved in the entry of the virus into the host cell. Several medicinal plants have been identified so far which show significant inhibitory results against dengue but still there is a need of proper medicine which can show promising results. In future, exploration of interaction of *Aedes albopictus* and other mosquito species is required. *Toxorhynchites* mosquitoes should be searched out for their predatory role against *Aedes albopictus* and *Aedes aegypti*. Vectoral role of *Aedes albopictus* and *Aedes aegypti* must be regulated in and between countries. In addition, the predominant serotype in dengue outbreaks can be managed through respective vaccine especially against the documented serotype.
