**8. Control of dengue fever**

Vaccines against dengue are difficult to develop. Nonetheless, as for December of 2015, CYD-TDV vaccine was approved for human use, and to date it remains as the sole vaccine with this status. As for specific treatments none is available, however various anti-viral natural entities are being evaluated for the elimination of dengue virus [ 32, 47, 48, 52–54].

There are several methods used to control dengue infection. The first and most important preventive measure is the prevention of contact with infected mosquitoes. *Aedes* mosquitoes usually have biting preferences during daytime and its contact can be minimized in various ways, for example, proper management of stored water and wastes, use of insecticides to eradicate the mosquitoes, use of mosquito nets and coils as well as repellents, use of wearing which minimize the exposed body surface. Insecticide treated nets (ITNs) are also available in the market for the protection of people including young children, pregnant women, old people [55].
