4.1.2. Challenges


To date, there are several DENV vaccines under development, with some in phase 3 safety and efficacy testing. These include inactivated, live attenuated, recombinant subunit, viral vectored, and DNA vaccines. Dengue vaccine development has aimed to elicit a neutralizing antibody response, as T cells are assumed to contribute a minor or secondary role in dengue vaccine-mediated protection. Next, we will describe each of these vaccines.

#### 4.2. Vaccine types
