**7. Conclusion**

Dry eye disease is an inseparable part of the both types of Sjögren's syndrome. There is no specific test to diagnose it—for everyday practice, several tests are used to diagnose and to interpret the severity of the problem. Moreover, though it is more severe than in other diseases, there is no specific test for DED in SS.

The treatment of DED in SS is also the same as in other patients. Patients are treated with both topical and systemic therapies. There are some trials to use immunosuppressive agents for DED in SS to provide relief to eye dryness symptoms, but there are not enough verified studies on it.

Both in diagnostic and therapeutic problems of DED, there are still challenges for the future and need further multicenter, double-blind, randomized studies.
