*Video-Assisted Thoracoscopy in the Management of Primary and Secondary Pneumothorax DOI: http://dx.doi.org/10.5772/intechopen.83669*

the complications of these procedures were not taken into account favoring chemical or mechanical pleurodesis, in addition to wedge resection to remove the source of the air leak [21, 22]. Mechanical pleurodesis should be considered on a case-by-case basis with good clinical judgment. This should be avoided in patient who may have a bleeding tendency either due to medications or underlying disease. A chemical pleurodesis would be appropriate using an agent that cause aseptic inflammation in the pleura and facilitate pleural adhesion. Debate continues over the most effective chemical pleurodesis agent to use which has led to the widest variation in overall technique among all of these strategies. Graduated talcum of particle size <10 mic m is the most popular currently and has a long-standing history as an effective and trusted agent for pleurodesis. In the past, tetracycline and doxycycline have been used; however, the success rate is lower than the graduated talcum powder [23–25]. Marcheix et al. published a large study of 603 consecutive patients who underwent VATS pleurodesis using silver nitrate for primary spontaneous pneumothorax. While only 39.6% of these cases involved wedge resection and pleurodesis, the recurrence rate at 1 month was 0.5% in this group. The last 250 patients were included in a longer-term follow-up (2.9 ± 2.3 years) in which the recurrence rate was approximately 1.1%; however, only 73% of patients were actually contacted and this represents 31% of the total study population [26]. While it is difficult to draw concrete conclusions from this study, it is clear that silver nitrate can be an effective pleurodesis agent. Similar studies exist showing minocycline to be an effective agent as well [27].

When comparing VATS to other treatment modalities, such as aspiration, chest tube drainage, and pleurodesis, a recent meta-analysis of all available randomized control trials showed that VATS had the most favorable results with regard to recurrence and hospitalization days [21, 22]. The addition of pleurodesis to VATS bullectomy compared to VATS bullectomy alone further decreases recurrence rates, although this strategy comes with associated complications that include pain [21, 22]. Given the increased complications that arise from pleurodesis, some novel attempts at replacing the procedure, and at the same time achieving the same goal of promoting adhesions, have been developed. The use of an absorbable cellulose mesh and fibrin glue that are placed over blebectomy staple lines has been studied as an alternative to pleurodesis, with promising results [28]. This technique has been found to be noninferior in terms of recurrence rates when compared to pleurodesis and is without the complications of bleeding, pain, and Horner's syndrome that are associated with mechanical pleurodesis. The cost of these biological materials should be taken into consideration when the approach is sought. The use of autologous blood as a pleurodesis agent needs mention. Although various chemical agents all pose some risks, namely, significant pain or rarely development of acute respiratory distress syndrome, pleurectomy carries with it significant pain and bleeding. Autologous blood has been utilized in some instances with good success [29]. The majority of the literature on this topic involves using blood to treat persistent air leaks in the postoperative period. While this data cannot be directly utilized to construct guidelines for spontaneous pneumothorax, based on the body of evidence that exists, its reported efficacy is so compelling that one wonders if it could be similarly effective in this operative setting.

Chang and colleagues compared pleurodesis combined with wedge resection utilizing "needlescopic" VATS technique with apical pleurectomy [30]. It is accurate to think of this technique as analogous to VATS, one 12 mm port for standard VATS instruments and the chest tube to that needlescopic technique which combines three 3 mm ports for "mini" endograspers and a "needlescope." In addition to demonstrating that pleurectomy was technically feasible, utilizing needlescopy with comparable pain indices, duration of chest tube drainage, and hospital stay, it also suggested a lower recurrence rate, 0%, when compared to the abrasion group, 8.6%. Studies comparing traditional VATS to needlescopic technique are lacking; however, in this author's experience, the former can be completed easily with only two 5 mm and

*Pneumothorax*

**Figure 2.**

*posterior port.*

Once safely in the chest, the lungs are carefully inspected to identify any bullous changes and to detect the source of the air leak. Blebs will be air-filled areas of the lung less than 1 cm in size compared to bullae which are greater than 1 cm in size. Adhesions should be identified and lysed to allow for complete evaluation of the lung. Care should be taken to obtain hemostasis if any bleeding from the adhesions is encountered. Bullae that are identified can be stapled using an endo-stapler without crossing over any portion of the bullae in the staple line, as this may increase risk of recurrence. There should be good margin with the stapler traversing only "healthy" lung tissue in patients with spontaneous primary pneumothorax.

*Port placements for the classical three-port video-assisted thoracoscopic surgery. Different configurations, change according to the visual and staple requirements (a) camera through central port (b) Camera through* 

Mechanical pleurodesis involves creating abrasions to the pleural surface, or perform-

ing a limited pleurectomy, to initiate an inflammatory response which results in the formation of adhesions and prevents the lung from collapsing in situations of recurrence. The pleural abrasion is typically performed using an electrocautery scratch pad or gauze (**Figure 3**). Care should be taken when working at the apex, as a Horner's syndrome can occur if there is any injury to the stellate ganglion of the sympathetic chain. Additional operative complications include bleeding, particularly from intercostal or mammary vessels, and pain. One randomized prospective study comparing wedge resection to wedge resection, and adjunct mechanical pleurodesis, resulted in no difference in recurrence rates but did show an increase in complications for the pleurodesis group [20]. A meta-analysis comparing the different combinations of intraoperative treatment for primary spontaneous pneumothorax found that wedge resection combined with chemical pleurodesis, as well as wedge resection, combined with both mechanical pleural abrasion and chemical pleurodesis, had the lowest recurrence rates. Although

**30**

**Figure 3.**

*Pleural abrasion using electrocautery scratch pad (a) before and (b) after.*

a 10 mm port, a similar total incision length to needlescopy with one less incision overall, and can even be accomplished with a single 5 mm and a single 10 mm port. This fact calls into question the benefit of this modification to traditional VATS.

Two additional trials demonstrating the superiority of pleurodesis with pleurectomy over abrasion are worth mentioning. Huh and colleagues performed a similar study of 207 consecutive patients who underwent VATS wedge and either apical pleurectomy or pleural abrasion at a single Korean institution [31]. Although the recurrence rate in the pleurectomy group was higher in this study at 9.1% than the previous study, it was still lower than that of the abrasion group, 12.8%, which reached statistical significance. The second study is from the pediatric literature and showed that when combined with apical bleb resection pleurectomy led to a significantly lower rate of pneumothorax recurrence when compared to pleural abrasion, 8.8 vs. 40%, in the management of spontaneous primary pneumothorax in teenage patients ranging from 14 to 17 years old [32]. It should be noted that although these were retrospective studies, the follow-up period for the VATS wedge with pleurectomy group in the two Asian studies was significantly longer than that of the wedge with abrasion group, raising the possibility that the recurrence rate in the latter group may be underreported.

Secondary pneumothorax in the majority includes patients with chronic obstructive pulmonary disease and emphysema. The underlying may have homogenous or heterogeneous emphysema, and identifying the area of air leak can be difficult except in patients with large bullous disease. Other surgical strategies have been developed for the approach of pneumothorax in this patient population. When patients present with extensive emphysema of the underlying lung, the strategies of lung volume reduction surgery may be applicable. Lung volume reduction surgery (LVRS) is well studied by the National Emphysema Treatment Trial (NETT). LVRS in selected patients with emphysema as a treatment modality improved quality of life and length of survival compared to medical therapy alone [33]. A comparison of LVRS to medical therapy identified higher early mortality rates in the surgical group than medical treatment alone, 7.9 vs. 1.3%, though overall mortality saw no difference. The surgical group was further broken down into minimally invasive versus median sternotomy, identifying comparable mortality rates between the two arms. When comparing exercise capacity between the surgical and medical groups, there was a significant difference 24 months after treatment in favor of surgery, improving 15% of patients compared to 3% in the medical treatment arm. Application of NETT trial findings is useful and can provide clarity when approaching a patient presenting with secondary pneumothorax with severe emphysema. Work-up on these patients often show low FEV1 values with high residual volumes and lung capacity. In these patients applying the principle of lung volume reduction to include the suspected areas, this will help to treat the secondary pneumothorax as well as improving overall outcome. However this patient population should be approached with care and best treated in centers with expertise in LVRS. Often the staple lines will require reinforcement, and additional adjunctive procedures may be necessary such as pleural tent to manage air leak (**Figure 4a**) [34].

Patients presenting with secondary pneumothorax with underlying fibrotic parenchymal pathology present additional challenges [35]. These lungs have poor compliance, and air leak management will require a different approach that may need sealants rather than resection and use of pleural tent to manage the air leak and the space (**Figure 4b**). Use of tissue sealants instead of stapling, or in addition to stapling, may be necessary if the patient is deemed a candidate for surgical intervention. If not a surgical candidate, conservative approach with chemical pleurodesis would be appropriate.

**33**

*Video-Assisted Thoracoscopy in the Management of Primary and Secondary Pneumothorax*

The most important consideration among patients with secondary spontaneous pneumothorax is that by definition, the patients are sicker than primary spontaneous pneumothorax patients because of the underlying lung condition at baseline. This lung pathology almost always accompanies in advanced age, with finding the mean age of patients presenting with primary spontaneous pneumothorax is younger than secondary pneumothorax. It stands to reason that this age brings with it more medical comorbidities and, as a result, reduced physiologic reserve, therefore necessitating prompt action, even when the size of the pneumothorax is relatively small. Furthermore, if one occurrence of pneumothorax in this patient population represents a life-threatening condition, then a recurrence could possibly be even more life-threatening. Therefore, one could argue that preventing recurrence of pneumothorax is more of a matter of life and death in secondary pneumothorax patient compared to primary spontaneous pneumothorax for the reasons

*(a) Using reinforcement techniques to reduce air leak at staple line and (b) using pleural tent to manage air* 

While agreement is coalescing that among patients treated with surgery for spontaneous pneumothorax, VATS should be the primary method of access. The diseased lung should be excised, and some form of pleurodesis should be added.

The strategy of postoperative chest tube management following surgical treatment for pneumothorax has not been extensively studied. Some surgeons advocate the placing of chest tubes to allow wall suction to increase the lung-chest wall apposition after pleurodesis, while others prefer to leave chest tubes on water seal in the immediate postoperative period. One study has compared these two strategies for chest tube management, demonstrating that placing patients on −20 cm H2O suction resulted in increased chest tube duration, hospital stay, and prolonged air leak compared to those patients on no suction [38]. As long as pleural apposition is noted on chest radiograph postoperatively, the use of suction can be avoided that

Some suggest that the cost and length of hospital stay might be reduced by instituting "clever" drainage strategies. One such approach is the use of digital electronic drainage systems to manage chest tubes. Removal of chest drains remains an important factor in timing of discharge from the hospital following lung resection. Since data was first published on the first digital suction device in 2006, there has been increased interest in the idea of utilizing objective data from these devices to dictate timing of the removal of chest drains, thereby reducing inter-operator variability and hopefully length of stay [39]. A group in Korea expanded on this idea by utilizing Wi-Fi-enabled digital suction devices in the postoperative management of chest drainage tubes in patients undergoing VATS wedge resection for primary spontaneous pneumothorax

listed above, as typically they have limited reserve [36, 37].

Several other areas of interest warrant attention as well.

suggest prolonged air leak and subsequent hospital stay.

*DOI: http://dx.doi.org/10.5772/intechopen.83669*

**Figure 4.**

*leak and space in a noncompliant lung.*

*Video-Assisted Thoracoscopy in the Management of Primary and Secondary Pneumothorax DOI: http://dx.doi.org/10.5772/intechopen.83669*

**Figure 4.**

*Pneumothorax*

the latter group may be underreported.

a 10 mm port, a similar total incision length to needlescopy with one less incision overall, and can even be accomplished with a single 5 mm and a single 10 mm port. This fact calls into question the benefit of this modification to traditional VATS. Two additional trials demonstrating the superiority of pleurodesis with pleurectomy over abrasion are worth mentioning. Huh and colleagues performed a similar study of 207 consecutive patients who underwent VATS wedge and either apical pleurectomy or pleural abrasion at a single Korean institution [31]. Although the recurrence rate in the pleurectomy group was higher in this study at 9.1% than the previous study, it was still lower than that of the abrasion group, 12.8%, which reached statistical significance. The second study is from the pediatric literature and showed that when combined with apical bleb resection pleurectomy led to a significantly lower rate of pneumothorax recurrence when compared to pleural abrasion, 8.8 vs. 40%, in the management of spontaneous primary pneumothorax in teenage patients ranging from 14 to 17 years old [32]. It should be noted that although these were retrospective studies, the follow-up period for the VATS wedge with pleurectomy group in the two Asian studies was significantly longer than that of the wedge with abrasion group, raising the possibility that the recurrence rate in

Secondary pneumothorax in the majority includes patients with chronic obstructive pulmonary disease and emphysema. The underlying may have homogenous or heterogeneous emphysema, and identifying the area of air leak can be difficult except in patients with large bullous disease. Other surgical strategies have been developed for the approach of pneumothorax in this patient population. When patients present with extensive emphysema of the underlying lung, the strategies of lung volume reduction surgery may be applicable. Lung volume reduction surgery (LVRS) is well studied by the National Emphysema Treatment Trial (NETT). LVRS in selected patients with emphysema as a treatment modality improved quality of life and length of survival compared to medical therapy alone [33]. A comparison of LVRS to medical therapy identified higher early mortality rates in the surgical group than medical treatment alone, 7.9 vs. 1.3%, though overall mortality saw no difference. The surgical group was further broken down into minimally invasive versus median sternotomy, identifying comparable mortality rates between the two arms. When comparing exercise capacity between the surgical and medical groups, there was a significant difference 24 months after treatment in favor of surgery, improving 15% of patients compared to 3% in the medical treatment arm. Application of NETT trial findings is useful and can provide clarity when approaching a patient presenting with secondary pneumothorax with severe emphysema. Work-up on these patients often show low FEV1 values with high residual volumes and lung capacity. In these patients applying the principle of lung volume reduction to include the suspected areas, this will help to treat the secondary pneumothorax as well as improving overall outcome. However this patient population should be approached with care and best treated in centers with expertise in LVRS. Often the staple lines will require reinforcement, and additional adjunctive procedures may be necessary such as pleural tent to manage

Patients presenting with secondary pneumothorax with underlying fibrotic parenchymal pathology present additional challenges [35]. These lungs have poor compliance, and air leak management will require a different approach that may need sealants rather than resection and use of pleural tent to manage the air leak and the space (**Figure 4b**). Use of tissue sealants instead of stapling, or in addition to stapling, may be necessary if the patient is deemed a candidate for surgical intervention. If not a surgical candidate, conservative approach with chemical

**32**

air leak (**Figure 4a**) [34].

pleurodesis would be appropriate.

*(a) Using reinforcement techniques to reduce air leak at staple line and (b) using pleural tent to manage air leak and space in a noncompliant lung.*

The most important consideration among patients with secondary spontaneous pneumothorax is that by definition, the patients are sicker than primary spontaneous pneumothorax patients because of the underlying lung condition at baseline. This lung pathology almost always accompanies in advanced age, with finding the mean age of patients presenting with primary spontaneous pneumothorax is younger than secondary pneumothorax. It stands to reason that this age brings with it more medical comorbidities and, as a result, reduced physiologic reserve, therefore necessitating prompt action, even when the size of the pneumothorax is relatively small. Furthermore, if one occurrence of pneumothorax in this patient population represents a life-threatening condition, then a recurrence could possibly be even more life-threatening. Therefore, one could argue that preventing recurrence of pneumothorax is more of a matter of life and death in secondary pneumothorax patient compared to primary spontaneous pneumothorax for the reasons listed above, as typically they have limited reserve [36, 37].

While agreement is coalescing that among patients treated with surgery for spontaneous pneumothorax, VATS should be the primary method of access. The diseased lung should be excised, and some form of pleurodesis should be added. Several other areas of interest warrant attention as well.

The strategy of postoperative chest tube management following surgical treatment for pneumothorax has not been extensively studied. Some surgeons advocate the placing of chest tubes to allow wall suction to increase the lung-chest wall apposition after pleurodesis, while others prefer to leave chest tubes on water seal in the immediate postoperative period. One study has compared these two strategies for chest tube management, demonstrating that placing patients on −20 cm H2O suction resulted in increased chest tube duration, hospital stay, and prolonged air leak compared to those patients on no suction [38]. As long as pleural apposition is noted on chest radiograph postoperatively, the use of suction can be avoided that suggest prolonged air leak and subsequent hospital stay.

Some suggest that the cost and length of hospital stay might be reduced by instituting "clever" drainage strategies. One such approach is the use of digital electronic drainage systems to manage chest tubes. Removal of chest drains remains an important factor in timing of discharge from the hospital following lung resection. Since data was first published on the first digital suction device in 2006, there has been increased interest in the idea of utilizing objective data from these devices to dictate timing of the removal of chest drains, thereby reducing inter-operator variability and hopefully length of stay [39]. A group in Korea expanded on this idea by utilizing Wi-Fi-enabled digital suction devices in the postoperative management of chest drainage tubes in patients undergoing VATS wedge resection for primary spontaneous pneumothorax

[40]. The devices utilized in this study could not only remotely deliver information to providers regarding suction power and volume of air leaks, but they could also allow the providers to remotely control settings on the suction device. In keeping with the growing reliance on mobile technology in our society, clinicians were able to monitor and control device parameters using a smartphone app. Findings in this randomized control trial were consistent with previous studies which showed a statistically significant decrease in chest tube duration, length of stay, and, consequently, overall cost. The investigators established the safety and feasibility of managing pleural drains remotely opening the possibility of discharging patients home with the drains in place and monitoring their progress at home. One limitation of this particular study was that investigators elected not perform any form of pleurodesis to limit the postoperative parameters, thereby reducing the generalizability of the data onto patients who received the gold standard of treatment for spontaneous pneumothoraces, namely, resection and pleurodesis. Despite this limitation, recurrences in this study with 6 months of followup data remained low at about 3.4%. Given the rapidity with which mobile technology is advancing, it is not hard to envision a time when physicians can monitor the character and volume of effluent from these devices as well, thereby decreasing the need for inpatient care to that of reaching a stable level of analgesia with only oral agents.

There are also financial implications that should be considered when evaluating the differences between open and minimally invasive approaches to the management of pneumothorax and use of adjuncts. In a small Italian study from 1996 comparing VATS versus thoracotomy for management of recurrent spontaneous pneumothorax at a time when reusable VATS instruments were not yet widely available, VATS was still found to have a 22.7% cost savings compared to thoracotomy even when expensive disposable VATS equipment was used. The cost savings at that time were realized in the decreased duration of postoperative hospitalization seen in patients treated with VATS compared to open thoracotomy [10, 41]. A more recent study identified these cost savings in complication, ICU admission, length of hospitalization, operative time, and chest tube duration [42], further supporting the argument of minimally invasive intervention compared to open.

As application of robotic techniques become readily available to thoracic surgeons, it is likely the technology could be developed in pinpointing air leak and precision application of treatment during surgical intervention. Furthermore, there is an increasing interest in using computerized chest drainage systems to allow for an early and safe removal of chest tube or remote management of the tube in outpatient settings.

Anesthetic concerns are typically left out of discussion of surgical treatment. However, one paper that deserves mention evaluated the feasibility of performing awake VATS bullectomy and abrasion. In this randomized control trial in Rome, Italy, patients were randomized to undergo either awake VATS with thoracic epidural anesthesia or traditional VATS with general anesthesia and single-lung ventilation [43]. The sample size was relatively small to be sure, with 21 in the investigational arm and 23 in the control arm, but the results of the trial were striking nonetheless. Not only was awake VATS technically feasible, with all cases being completed as planned and zero conversions to general anesthesia, but pain scores and patient satisfaction with anesthesia favored the awake approach over the traditional VATS. What is particularly interesting in this study is that the cost data also favored the awake technique (2540 ± 352 € vs. 3550 ± 435 €, p < 0.0001). This is mostly because anesthesia time (25.0 ± 6.0 min vs. 35.5 ± 10.0 min, p < 0.001), recovery room time (20 ± 15.0 min vs. 30 ± 15.0 min, p = 0.001), global OR time (78.0 ± 20.0 min vs. 105.0 ± 15.0 min, p < 0.001), and hospital stay (2.0 ± 1.0 d vs. 3.0 ± 1.0 d, p < 0.0001) were all shorter for the awake group [43]. With a significant portion of the debate over how best to control rising health-care costs with focus on resource utilization and hospital stay, it is a wonder why this technique is not more widely utilized, let alone discussed.

**35**

**Conflict of interest**

None.

**5. Conclusion**

*Video-Assisted Thoracoscopy in the Management of Primary and Secondary Pneumothorax*

The rise of minimally invasive surgical treatment of spontaneous pneumothorax has had a great impact on the way in which these are approached. Prior to the adoption of VATS techniques, many patients were deemed too sick to tolerate either single-lung ventilation or the ventilator assistance required in the perioperative period or both. Ichinose and colleagues retrospectively evaluated the records of all patients operated on for secondary pneumothorax, 183 cases, at a single institution between 1993 and 2014 and reported on the outcome of their surgical treatment [37]. Other than the underlying lung pathology, of which interstitial pneumonia had the worst survival, the group identified open surgical treatment as the greatest risk factor for treatment failure defined as the occurrence of in-hospital mortality, postoperative complications, and death within 6 months or ipsilateral recurrence within 2 years. In noting the dearth of evidence regarding minimally invasive surgical techniques for secondary pneumothorax, Galvez and colleagues highlight the promise of non-intubated VATS (NI-VATS) surgery in this population [44]. In addition to the benefits of this technique described above for PSP, the benefits of avoiding general anesthesia in these patients also include decreasing risk of ventilator dependency, decreasing risk of pulmonary infections, secretions of orotracheal intubation, and a reduction in overall pulmonary complications by half. Much of the pleurodesis reported in this literature review involved fibrin glue, polyglycolic acid sheets, and autologous blood or some combination of these. It seems obvious that because of the decreased physiologic and cardiopulmonary reserve often seen in patients with secondary pneumothorax, there should be great interest in developing additional minimally invasive surgical techniques and investigating their benefits.

Despite differences in etiology of pneumothorax, the management should be directed at expeditious bedside and, ultimately, surgical management for patients who do not completely resolve their pneumothorax non-operatively [45]. We advocate for bedside chest tube placement under local anesthetic for nearly all patients who present with spontaneous pneumothorax, except those with small pneumothorax that remain stable on follow-up radiographic imaging. Following chest tube placement, if the pneumothorax fully resolves and there is no ongoing air leak, these patients can have their chest tube water sealed and subsequently removed as early as the day after hospital presentation. Patients with recurrent bilateral pneumothorax, patients who present for the first time without ready access to medical care, patients with profession or hobbies that make them at higher risk from developing recurrence, or patients with persistent air leak should undergo surgical intervention whenever possible. The operative approach should favor VATS over open thoracotomy for both pleurodesis/pleurectomy and resection of blebs. Our approach is always to perform pleurodesis following the blebectomy or remove the source of the air leak. Our preferred approach in younger patients is mechanical pleurodesis, and in patients above 65 years of age, use graded talc. In patients presenting with recurrences following a previous pleurodesis, we reserve the apical pleurectomy. In patients with secondary pneumothorax, we have lower threshold to reinforce staple line or perform pleural tent in addition to the above. This overall strategy will facilitate timely treatment in this patient population and accomplish it in a minimally invasive manner that aligns

with other modern surgical approaches in the field of thoracic surgery.

*DOI: http://dx.doi.org/10.5772/intechopen.83669*

*Video-Assisted Thoracoscopy in the Management of Primary and Secondary Pneumothorax DOI: http://dx.doi.org/10.5772/intechopen.83669*

The rise of minimally invasive surgical treatment of spontaneous pneumothorax has had a great impact on the way in which these are approached. Prior to the adoption of VATS techniques, many patients were deemed too sick to tolerate either single-lung ventilation or the ventilator assistance required in the perioperative period or both. Ichinose and colleagues retrospectively evaluated the records of all patients operated on for secondary pneumothorax, 183 cases, at a single institution between 1993 and 2014 and reported on the outcome of their surgical treatment [37]. Other than the underlying lung pathology, of which interstitial pneumonia had the worst survival, the group identified open surgical treatment as the greatest risk factor for treatment failure defined as the occurrence of in-hospital mortality, postoperative complications, and death within 6 months or ipsilateral recurrence within 2 years. In noting the dearth of evidence regarding minimally invasive surgical techniques for secondary pneumothorax, Galvez and colleagues highlight the promise of non-intubated VATS (NI-VATS) surgery in this population [44]. In addition to the benefits of this technique described above for PSP, the benefits of avoiding general anesthesia in these patients also include decreasing risk of ventilator dependency, decreasing risk of pulmonary infections, secretions of orotracheal intubation, and a reduction in overall pulmonary complications by half. Much of the pleurodesis reported in this literature review involved fibrin glue, polyglycolic acid sheets, and autologous blood or some combination of these. It seems obvious that because of the decreased physiologic and cardiopulmonary reserve often seen in patients with secondary pneumothorax, there should be great interest in developing additional minimally invasive surgical techniques and investigating their benefits.
