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## Meet the editors

Marwa Zakaria Mohamed is a lecturer of pediatrics and pediatric hematology and oncology, Pediatric Department, Zagazig University, Egypt. She is an active member in SIOP, EHA, and HAA. Professional training and workshops include ICH GCP, EHA-Master Class, and Bite Size Master Class. She has received training from Wilkins-Barrick Society of Neurooncology (SNO), Morocco, the Training Program in Pediatric Nutrition, School of

Medicine, Boston University, 2017, and the International Preceptorship in Thalassemia, Beirut, September 2015. She has received international scholarships and awards, including SIOP Scholarship and EHA-HOPE in 2017 and 2018, respectively. She has been a guest speaker at numerous pediatric oncology and hematology meetings, and has over 20 international research publications in the field of pediatrics. She is the chief editor of an online book, the author of two online book chapters, and a reviewer in international and national peer-reviewed journals *(Medicine* (*Baltimore)*, IntechOpen Publisher; *Frontiers in Pediatrics*, *Molecular Medicine Reports*, and *Zagazig University Medical Journal*). She has been a subinvestigator in five international trials.

Tamer Hasan Hassan is Professor of Pediatrics and Pediatric Hematology and Oncology, Pediatric Department, Zagazig University, Egypt. He is an active member at EHA, SIOP, and HAA, and has over 50 international research publications in pediatrics. He is the author of two online book chapters. Professional training and workshops include ICH GCP Online Training, training in the 10th International Educational Course on Thalassemia, Cyprus

2006, training in the Pediatric Stem Cell Transplantation Unit in Ulm University, and completion of the EHA Master Class and Bite Size Master Class 2016 and 2017, respectively. He has been awarded many international scholarships, including SIOP, EHA-HOPE, Hemophilia Preceptorship in Saint Luc Hospital, Belgium, and ITP Preceptorship in Dmitry Rogachev National Research Center, Moscow. He is the academic editor of the *Medicine (Baltimore) Journal*, and a reviewer for many international journals (*Hemophilia*, *Medicine*, *Oncology Letters*, *Child Neurology*). He is the primary investigator in two international clinical trials and subinvestigator in 10 international trials.

**Preface III**

Introduction to Pediatric Hematology and Oncology **1**

**Chapter 1 3**

Nocturnal Enuresis in Sickle Cell Anemia **9**

**Chapter 2 11**

Inherited Bone Marrow Failure Syndromes **23**

**Chapter 3 25**

Malignant Tumors in Children **45**

**Chapter 4 47**

Inherited Bone Marrow Failure and Chromosome Instability Syndromes

Clinical Manifestations and Diagnosis of Malignant Tumors in Children

Introductory Chapter: Contemporary Pediatric Hematology and Oncology

**Section 1**

Contents

**Section 2**

**Section 3**

*and Ikenna K. Ndu*

*by Zhan He Wu*

*by Maxim Yu. Rykov*

**Section 4**

and their Cancer Predisposition

*by Marwa Zakaria and Tamer Hassan*

Nocturnal Enuresis in Children with Sickle Cell Anemia *by Samuel N. Uwaezuoke, Chizoma I. Eneh, Osita U. Ezenwosu* 

## Contents


Preface

*Contemporary Pediatric Hematology and Oncology* is the first edition, and has been a wonderful opportunity to bring together the expertise of hematology and oncology doctors from different communities. The book is designed to be the first step in advanced practice working with pediatric hematology/oncology patients. Specific issues related to young children and adolescents with cancer and hematologic

Three contributors and two editors participated in writing this book. The book is divided into four sections: Introduction to Pediatric Hematology and Oncology, Nocturnal Enuresis in Sickle Cell Anemia, Inherited Bone Marrow Failure

Syndromes, and Malignant Tumors in Children. Many tables and illustrations are

Section I focuses on a general introduction to pediatric hematology and oncology and the great evolution that had been made regarding recent and advanced molecular diagnostic methods that have paved the way for novel therapeutic potentials in

Section II focuses on benign hematology, including hemoglopanopathies and unusual clinical associations, with emphasis on how to diagnose and treat these

Section III illustrates the dilemma of bone marrow failure with a comprehensive overview of the genetic bases of different types, etiology, symptoms and clinical signs, diagnostic and laboratory testing, new areas of classification, therapeutic

Section IV focuses on pediatric cancers—the leukemias, lymphomas, and solid tumors. The most common pediatric tumors as well as some rare tumors are discussed in regard to epidemiology, etiology, molecular genetics, symptoms and clinical signs, diagnostic and laboratory testing, staging and classification, treat-

The editors of *Contemporary Pediatric Hematology and Oncology* wish to recognize, thank, and acknowledge everyone who participated in writing this book. We are profoundly aware of the personal time and commitment that was devoted to make this an outstanding resource, and we are grateful. It is our hope that all healthcare,

included for quick reference in the clinical setting.

the field of pediatric hematology and oncology.

disorders are discussed.

disorders.

modalities, and prognosis.

ment, prognosis, and follow-up care.
