**9. Kidney disease in CD**

Glomerular IgA deposition is common, occurring in as many as one-third of patients. Although the clinical manifestation is not evident, due to no associated complement deficiency. This indicates that a high circulating load of polyclonal IgA is not adequate to cause nephritis, but other abnormalities of IgA are necessary to translate into mesangial activation and glomerular injury. This mesangial IgA deposition is also seen in healthy individuals from 3 to 16% [74]. Thus its association with other disease is relatively high.
