**Urinary Tract Injuries in Low-Resource Settings**

Mathias Onsrud *Oslo University Hospital, Norway* 

## **1. Introduction**

312 Hysterectomy

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the pelvic floor impact questionnaire (PFIQ-7), pelvic floor distress inventory (PFDI-20) and pelvic organ prolapse/urinary incontinence sexual questionnaire The purpose of this chapter is to elucidate some serious complications of hysterectomy when performed in low-resource countries. The main target is doctors intending to work under such conditions.

Urinary tract injuries are encountered in high-resource settings as well as in low-resource settings but comparative incidence data are lacking. Particular for low resource countries is the difficult situation under which the causative intervention was performed. Table 1 enumerates some general factors that can influence the risk of surgery. All of these factors may be present at the same time in the same place. Bleeding complications and postoperative infections are frequent. Conditions like HIV, tuberculosis and female genital schistosomiasis may intervene. A high prevalence of cervical cancer must be remembered. Factors relevant for the hysterectomy procedure in particular are: General anesthesia with muscle relaxation is seldom available; operations must be done in spinal anesthesia normally. Suitable instruments and equipment like suction and diathermia are often lacking. Minimal invasive procedures (laparoscopy, endoscopy) are seldom available.

Patient's nutritional status and co-morbidity Disease stage and duration Preoperative diagnosis and patient preparation Laboratory facilities Blood supply and antibiotics Anesthesia Surgeon's training and supervision Instruments available Postoperative service Follow-up

Table 1. Factors influencing the operative risk in low-resource settings

## **2. Types of urinary tract injuries**

Two main types of urinary tract injuries are encountered after hysterectomy: 1) bladder damage, with vesicovaginal fistula as the ultimate manifestation, and 2) ureteric damage, ranging from crushing to the most severe sequel, ureterovaginal fistulas. Probably, a large

Urinary Tract Injuries in Low-Resource Settings 315 with experience both from Turkey and Niger found gynecologic surgery to be the main cause of fistula in the former country and obstetric complications in the latter (8). A change during the later decades from a mainly obstetric to a mainly iatrogenic etiology has been reported from some developing countries (9,10). The quality of obstetric care and surgical

Amongst 597 patients operated for urogenital fistulae at Panzi hospital from November 2005 till November 2007, 21 fistulas (3.5%) were related to a previous hysterectomy (11,12). Nine of these women (42.9%) had a ureterovaginal fistula compared to 27 out of 567 women (4.8%) in the obstructed labor group (OR 15, 95%CI 5.8-38.7) (Table 3). Twelve (57.1%) of the hysterectomy related fistulas were of the vesicovaginal type and located high up in the vagina, including one vesicocervical fistula after a subtotal hysterectomy. Vesicovaginal fistulas located in the lower part of vagina or involving urethra or its sphincter were not seen among the hysterectomy associated cases but were frequent in the obstructed labor group, 36.7% (208 of 567). None of the hysterectomy associated fistulas were surrounded by fibrosis or had a fistula size of more than 2 cm as compared to 64% with scar fibrosis and 34% with size more than 2 cm for those caused by obstructed labor. This indicates that the

Cause Fistulas VVF VVF VUF UrVF Comb-

Obstructed labor 567 (95.0) 208 285 34 27 13

Emergency peripartum 9 (1.5) 4 1\* 4

gynecologic disease 9 (1.5) 5 4

gynecologic disease 3 (0.5) 2 1

Total 597 (100) 213 300 35 36 13 % 35.6 50.3 5.9 6.0 2.2

Table 3. Urogenital fistulas by cause and type. Panzi Hospital, Democratic Republic of

poor uterine contractility probable, although uterine rupture cannot be excluded.

Nine of the 21 postoperative fistulas (42.9%) appeared in women who had undergone an emergency peripartum hysterectomy. The indication for these hysterectomies is unknown. High median age (35 years) and the high median parity (8) make postpartum hemorrhage or

Sexual violence, infections 9 (1.5) 5 4

\*vesicocervical fistula after subtotal hysterectomy

Congo 2006-2007 (from ref.12)

VVF vesicovaginal fistula, VUF vesicouterine fistula, UrVF ureterovaginal fistula

All Type of urogenital fistula

N (%) N N N N N

low high inations

skills are important factors for this development.

**3.1 Data from the Democratic Republic of Congo** 

hysterectomy related fistulas had a "cleaner" origin.

Hysterectomy

Abdominal, for benign

Vaginal, for benign

part of ureteric occlusions with hydronephrosis/renal damage pass undetected due to lack of awareness and diagnostic means.

1. Bladder damage

Incidental cystotomy most often occur during deliberation of the bladder from the uterus. Abnormal anatomy due to large uterine size and adhesions after pelvic inflammatory disease or cesarean sections can make dissection difficult. For benign hysterectomies, a 2.5% incidence of incidental cystotomies (34 of 1317 operations) has been reported (1) with a subsequent development of vesicovaginal fistula in 11.7% (4 out of 34 injuries). The main risk factor for this sequel is the extent of the injury, but large uterus, heavy blood loss and tobacco use may also be of importance (2).

2. Ureteric damage

For major gynecologic surgery, an average incidence of ureteric injuries of about 0.4% has been reported - 19 out of 4665 procedures (3). Data from low-resource countries are lacking, but the incidence is presumably higher there. Injuries are associated with both abdominal and vaginal hysterectomy, simple abdominal hysterectomy being most common. Operations on residual adnexae are at particular risk, as are those with large myomas, especially if located in the cervical part of uterus (4). The right ureter and the left ureter are equally affected. A common site of injury is near the pelvic brim, dorsal to the infundibulopelvic ligament. Injuries in the parametrial area are located at 1) the site where ureter crosses under the uterine artery, 2) in the tunnel towards the bladder ("tunnel of Wertheim"), or 3) in the intramural part of the bladder. These injuries are more difficult to detect and to handle. Lesions on the lateral pelvic sidewall are less frequent.

The severity of damage ranges from crushing, through ligation, transection, angulation to resection and fistula formation as late sequel (Table 2). Ischemic damage can appear if the ureter is dissected free from its adventitial sheath for several centimeters. It is remarkable though how well ureter can tolerate ischemia provided no postoperative radiation is added.

Crushing Ligation Angulation Transection Resection Fistulation (late sequel)

Table 2. Types of operative ureteric injuries

## **3. Urogenital fistula**

Urogenital fistula is the most important late sequel of an operative injury to the urinary tract. In developing countries the great majority of urogenital fistulas are obstetric ("the African fistula"). Long-standing, obstructed labor coupled with inadequate obstetric care is the main reason for this (5,6). In comparison, fistulas considered to be complications to hysterectomy are relatively few. In Nigeria, 96.5% of fistulas were related to delivery (7). This contrasts with the situation in developed countries where the majority of fistulas are due to pelvic surgery, malignancy and severe inflammatory conditions. A group of surgeons

part of ureteric occlusions with hydronephrosis/renal damage pass undetected due to lack

Incidental cystotomy most often occur during deliberation of the bladder from the uterus. Abnormal anatomy due to large uterine size and adhesions after pelvic inflammatory disease or cesarean sections can make dissection difficult. For benign hysterectomies, a 2.5% incidence of incidental cystotomies (34 of 1317 operations) has been reported (1) with a subsequent development of vesicovaginal fistula in 11.7% (4 out of 34 injuries). The main risk factor for this sequel is the extent of the injury, but large uterus, heavy blood loss and

For major gynecologic surgery, an average incidence of ureteric injuries of about 0.4% has been reported - 19 out of 4665 procedures (3). Data from low-resource countries are lacking, but the incidence is presumably higher there. Injuries are associated with both abdominal and vaginal hysterectomy, simple abdominal hysterectomy being most common. Operations on residual adnexae are at particular risk, as are those with large myomas, especially if located in the cervical part of uterus (4). The right ureter and the left ureter are equally affected. A common site of injury is near the pelvic brim, dorsal to the infundibulopelvic ligament. Injuries in the parametrial area are located at 1) the site where ureter crosses under the uterine artery, 2) in the tunnel towards the bladder ("tunnel of Wertheim"), or 3) in the intramural part of the bladder. These injuries are more difficult to detect and to handle.

The severity of damage ranges from crushing, through ligation, transection, angulation to resection and fistula formation as late sequel (Table 2). Ischemic damage can appear if the ureter is dissected free from its adventitial sheath for several centimeters. It is remarkable though how well ureter can tolerate ischemia provided no postoperative radiation is added.

Urogenital fistula is the most important late sequel of an operative injury to the urinary tract. In developing countries the great majority of urogenital fistulas are obstetric ("the African fistula"). Long-standing, obstructed labor coupled with inadequate obstetric care is the main reason for this (5,6). In comparison, fistulas considered to be complications to hysterectomy are relatively few. In Nigeria, 96.5% of fistulas were related to delivery (7). This contrasts with the situation in developed countries where the majority of fistulas are due to pelvic surgery, malignancy and severe inflammatory conditions. A group of surgeons

of awareness and diagnostic means.

tobacco use may also be of importance (2).

Lesions on the lateral pelvic sidewall are less frequent.

1. Bladder damage

2. Ureteric damage

Crushing Ligation Angulation Transection Resection

Fistulation (late sequel)

**3. Urogenital fistula** 

Table 2. Types of operative ureteric injuries

with experience both from Turkey and Niger found gynecologic surgery to be the main cause of fistula in the former country and obstetric complications in the latter (8). A change during the later decades from a mainly obstetric to a mainly iatrogenic etiology has been reported from some developing countries (9,10). The quality of obstetric care and surgical skills are important factors for this development.

## **3.1 Data from the Democratic Republic of Congo**

Amongst 597 patients operated for urogenital fistulae at Panzi hospital from November 2005 till November 2007, 21 fistulas (3.5%) were related to a previous hysterectomy (11,12). Nine of these women (42.9%) had a ureterovaginal fistula compared to 27 out of 567 women (4.8%) in the obstructed labor group (OR 15, 95%CI 5.8-38.7) (Table 3). Twelve (57.1%) of the hysterectomy related fistulas were of the vesicovaginal type and located high up in the vagina, including one vesicocervical fistula after a subtotal hysterectomy. Vesicovaginal fistulas located in the lower part of vagina or involving urethra or its sphincter were not seen among the hysterectomy associated cases but were frequent in the obstructed labor group, 36.7% (208 of 567). None of the hysterectomy associated fistulas were surrounded by fibrosis or had a fistula size of more than 2 cm as compared to 64% with scar fibrosis and 34% with size more than 2 cm for those caused by obstructed labor. This indicates that the hysterectomy related fistulas had a "cleaner" origin.


VVF vesicovaginal fistula, VUF vesicouterine fistula, UrVF ureterovaginal fistula \*vesicocervical fistula after subtotal hysterectomy

Table 3. Urogenital fistulas by cause and type. Panzi Hospital, Democratic Republic of Congo 2006-2007 (from ref.12)

Nine of the 21 postoperative fistulas (42.9%) appeared in women who had undergone an emergency peripartum hysterectomy. The indication for these hysterectomies is unknown. High median age (35 years) and the high median parity (8) make postpartum hemorrhage or poor uterine contractility probable, although uterine rupture cannot be excluded.

Urinary Tract Injuries in Low-Resource Settings 317

Injury to the urinary tract is a common complication to peripartum hysterectomy. The most important risk factors for emergency cesarean hysterectomy are reported to be: uterine rupture, postpartum hemorrhage, cervical tears, placenta accreta and placenta previa. Previous cesareans and multiparity (para >5) increase the risk by 6.9 and 3.4, respectively (13). The risk factors mentioned are all commonly encountered in developing countries.

*Uterine rupture* represents a serious health problem with high maternal and perinatal mortality. In the least developed countries, rates up to 1% have been reported (14). In developed countries, most cases are scar ruptures related to a previous cesarean section, whereas in Sub-Saharan Africa 75% are associated with an unscarred uterus (14). Here, the basis for rupture is mainly cephalopelvic disproportion. A typical scenario is that the first baby was delivered stillborn after a long-lasting, obstructed labor and the following pregnancy ends up with a uterine rupture. Other risk factors for rupture are abnormal presentations and multiparity (14). Populations with a high cesarean delivery rate – and thereby a high prevalence of scarred uterus - are at risk. The consequences for future pregnancies can be disastrous if these women are living in areas with poor access to emergency obstetric service. In areas with an increasing cesarean section rate, more uterine

Obstructed labor is a common indication for cesarean section and few of the operations are planned. Cesarean delivery should protect against maternal mortality and morbidity and save the child. Nevertheless, 50% of women treated for fistula at Panzi hospital got their fistula despite a cesarean section was performed and 84% of the babies were stillborn. It is evident that in many cases, some form of assisted vaginal delivery would have been more appropriate. Unfortunately, the use of vacuum extraction has become rare and the cesarean delivery rate has increased in many areas (15,16). Fear of vertical HIV transmission is one

Most cases of uterine rupture are treated by hysterectomy. This major surgery is risky for patients in a bad general condition. Further, the loss of uterus and fertility has serious social consequences in many societies. Suturing, with or without sterilization, can be a safe alternative and has been used in more than 60% of cases in some reports (17,18). Additional ligature of the internal iliac arteries is sometimes necessary, and this technique should be known (19). A conservative approach necessarily implies that future pregnancies are strictly

*Postpartum hemorrhage* accounts for 34% of maternal mortality in developing countries compared to 13% in developed countries (20) and is an important indication for emergency hysterectomy. The most common causes are uterine atony (80%), retained placental fragments, genital tract lacerations and uterine rupture. Risk factors include a history of post partum hemorrhage or retained placenta, placental abruption, placenta praevia, uterine fibroids, hydramnios, multiple pregnancies, prolonged labor and instrumental delivery. Although an assessment of risk factors is important, post partum hemorrhage typically occurs unpredicted and all parturients are at the risk. Prompt handling is essential. Peripartum hysterectomy – cesarean or postpartum - can be a life saving procedure, although difficult and risky. The cervical edges can be difficult to identify and damage to vagina, bladder and ureters often occur. A supracervical hysterectomy is much less

factor for this development, lack of obstetrical training is another (12).

followed up of and a cesarean delivery performed in due time.

1. Emergency peripartum hysterectomy

scar ruptures has been observed (15).

Nine women had undergone abdominal hysterectomy for uterine myomas and 3 had vaginal hysterectomy performed as part of an operation for pelvic organ prolapse. For these patients with a gynecologic reason for the hysterectomy, the median age was 40 years and median parity 5, as compared to 22 years and parity 1, respectively, for women with fistula caused by obstructed labor (Table 4).


Table 4. Median age and parity at time of fistula appearance by cause (derived from ref. 12)

### **3.2 Diagnosis**

Vesicovaginal fistulas are normally visible high up in the vagina. Direct inspection for fistula is done after filling the bladder with diluted methylene blue. Dye will immediately be observed in the vagina or on a tampon left there ("tampon test"). Cystoscopy will confirm the fistula. Its localization in relation to the ureteric openings is of importance for planning of the operation. Sometimes, only sutures perforating the bladder mucosa or granulation tissue are observed.

Ureteric occlusion can be caused by inadvertent ligation giving ureteric stenosis and hydronephrosis. Symptomes can be flank pain or slow postoperative recovery only. This condition can pass undetected or be diagnosed late after permanent renal damage is induced. Sonography – an important diagnostic tool in low-resource countries - can be of great help. Intravenous pyelo-uretero-graphy and vesicography are available at some places whereas this is rarely the case for CT-scans and MRI.

Ureteric lacerations are generally detected early, about 50% of during operation and 50% during the first 2 weeks postoperatively. (3,4). Pain from uroplania or urine in the peritoneal cavity may appear, and sonography is then helpful. Urinary leakage through the vaginal top is more common. Creatinin measurement can be necessary to prove that the secretion really is urine. Dye inserted into the bladder will normally not leak to the vagina and cystoscopy is most often negative. Lack of urine secretion or intravenously infused dye from one of the ureteric openings is highly suggestive. Dye secretion to the vagina is confirmative. The ureterovaginal fistula is often not directly visible in the vagina.

#### **3.3 Causative interventions and prevention**

The types of hysterectomy covered in this chapter are those where urinary tract complications tend to occur most frequently: Emergency peripartum hysterectomy, abdominal hysterectomy and vaginal hysterectomy. Laparoscopic hysterectomy is seldom done under low-resource settings and will not be covered here.

Nine women had undergone abdominal hysterectomy for uterine myomas and 3 had vaginal hysterectomy performed as part of an operation for pelvic organ prolapse. For these patients with a gynecologic reason for the hysterectomy, the median age was 40 years and median parity 5, as compared to 22 years and parity 1, respectively, for women with fistula

Cause of fistula/type of operation Median age Median parity

Table 4. Median age and parity at time of fistula appearance by cause (derived from ref. 12)

Vesicovaginal fistulas are normally visible high up in the vagina. Direct inspection for fistula is done after filling the bladder with diluted methylene blue. Dye will immediately be observed in the vagina or on a tampon left there ("tampon test"). Cystoscopy will confirm the fistula. Its localization in relation to the ureteric openings is of importance for planning of the operation. Sometimes, only sutures perforating the bladder mucosa or granulation

Ureteric occlusion can be caused by inadvertent ligation giving ureteric stenosis and hydronephrosis. Symptomes can be flank pain or slow postoperative recovery only. This condition can pass undetected or be diagnosed late after permanent renal damage is induced. Sonography – an important diagnostic tool in low-resource countries - can be of great help. Intravenous pyelo-uretero-graphy and vesicography are available at some places

Ureteric lacerations are generally detected early, about 50% of during operation and 50% during the first 2 weeks postoperatively. (3,4). Pain from uroplania or urine in the peritoneal cavity may appear, and sonography is then helpful. Urinary leakage through the vaginal top is more common. Creatinin measurement can be necessary to prove that the secretion really is urine. Dye inserted into the bladder will normally not leak to the vagina and cystoscopy is most often negative. Lack of urine secretion or intravenously infused dye from one of the ureteric openings is highly suggestive. Dye secretion to the vagina is confirmative. The ureterovaginal fistula is often not directly visible in the

The types of hysterectomy covered in this chapter are those where urinary tract complications tend to occur most frequently: Emergency peripartum hysterectomy, abdominal hysterectomy and vaginal hysterectomy. Laparoscopic hysterectomy is seldom

Obstructed labor - vaginal delivery (n=226) 22 1

Emergency, peripartum (n=9) 35 8

(n=12) 40 5

Abdominal or vaginal, non-obstetric indication

whereas this is rarely the case for CT-scans and MRI.

**3.3 Causative interventions and prevention** 

done under low-resource settings and will not be covered here.

(years)

caused by obstructed labor (Table 4).

Hysterectomy (n=21)

**3.2 Diagnosis** 

tissue are observed.

vagina.

#### 1. Emergency peripartum hysterectomy

Injury to the urinary tract is a common complication to peripartum hysterectomy. The most important risk factors for emergency cesarean hysterectomy are reported to be: uterine rupture, postpartum hemorrhage, cervical tears, placenta accreta and placenta previa. Previous cesareans and multiparity (para >5) increase the risk by 6.9 and 3.4, respectively (13). The risk factors mentioned are all commonly encountered in developing countries.

*Uterine rupture* represents a serious health problem with high maternal and perinatal mortality. In the least developed countries, rates up to 1% have been reported (14). In developed countries, most cases are scar ruptures related to a previous cesarean section, whereas in Sub-Saharan Africa 75% are associated with an unscarred uterus (14). Here, the basis for rupture is mainly cephalopelvic disproportion. A typical scenario is that the first baby was delivered stillborn after a long-lasting, obstructed labor and the following pregnancy ends up with a uterine rupture. Other risk factors for rupture are abnormal presentations and multiparity (14). Populations with a high cesarean delivery rate – and thereby a high prevalence of scarred uterus - are at risk. The consequences for future pregnancies can be disastrous if these women are living in areas with poor access to emergency obstetric service. In areas with an increasing cesarean section rate, more uterine scar ruptures has been observed (15).

Obstructed labor is a common indication for cesarean section and few of the operations are planned. Cesarean delivery should protect against maternal mortality and morbidity and save the child. Nevertheless, 50% of women treated for fistula at Panzi hospital got their fistula despite a cesarean section was performed and 84% of the babies were stillborn. It is evident that in many cases, some form of assisted vaginal delivery would have been more appropriate. Unfortunately, the use of vacuum extraction has become rare and the cesarean delivery rate has increased in many areas (15,16). Fear of vertical HIV transmission is one factor for this development, lack of obstetrical training is another (12).

Most cases of uterine rupture are treated by hysterectomy. This major surgery is risky for patients in a bad general condition. Further, the loss of uterus and fertility has serious social consequences in many societies. Suturing, with or without sterilization, can be a safe alternative and has been used in more than 60% of cases in some reports (17,18). Additional ligature of the internal iliac arteries is sometimes necessary, and this technique should be known (19). A conservative approach necessarily implies that future pregnancies are strictly followed up of and a cesarean delivery performed in due time.

*Postpartum hemorrhage* accounts for 34% of maternal mortality in developing countries compared to 13% in developed countries (20) and is an important indication for emergency hysterectomy. The most common causes are uterine atony (80%), retained placental fragments, genital tract lacerations and uterine rupture. Risk factors include a history of post partum hemorrhage or retained placenta, placental abruption, placenta praevia, uterine fibroids, hydramnios, multiple pregnancies, prolonged labor and instrumental delivery. Although an assessment of risk factors is important, post partum hemorrhage typically occurs unpredicted and all parturients are at the risk. Prompt handling is essential. Peripartum hysterectomy – cesarean or postpartum - can be a life saving procedure, although difficult and risky. The cervical edges can be difficult to identify and damage to vagina, bladder and ureters often occur. A supracervical hysterectomy is much less

Urinary Tract Injuries in Low-Resource Settings 319 pyelogram, computed tomography, prophylactic ureteric stint have not shown to be preventive. The best prevention is that the surgeon always is aware of where the ureters is and stay safely away from it and preserving its adventitial sheath. Ureter should be visualized, not only palpated. The surgeon should know well the retroperitoneal approach and use it in all difficult cases. Special care should be taken when

Most vaginal hysterectomies are performed as part of a treatment for genital organ prolapse. Bladder and ureter injuries related to vaginal operations occur in all parts of the world. Register data from Finland showed an incidence of 0.2 bladder injuries per 1000 vaginal hysterectomies and the same incidence for ureteric injuries (1). Sixty-five percent of the complications were fistulas. In a series from France urinary tract injury occurred in 1.7% of 3076 vaginal hysterectomies - 54 bladder lesions and 1 ureteric lesion (28). It is reason to believe that the incidence of injury is higher in low-resource countries. Some institutions tend to performed hysterectomy also in cases with less pronounced genital organ prolapse. High incidence of cervical cancer and contraceptive need may be reasons for a liberal attitude to hysterectomy. However, the Manchester technique with cervical amputation is a less risky procedure. Recurrence and vault prolapsed are best prevented by building up the

Age, parity, body weight and mode of delivery are known risk factors (1.28) and are common for low-income and high-income countries. Multiparity, poor general condition and chronic infections are more prevalent in developing countries. High bacterial content in the vagina and particular inflammatory conditions like urogenital schistosomiasis and tuberculosis may be predisposing factors. Bladder damage should be avoided by careful dissection and ureters should be localized by palpation against a metal retractor in the

Most bladder lesions are detected during the operation. The bladder wall should be closed in two layers with nonperforating, absorbable sutures and an indwelling urinary catheter for 5 days. The ureteric ostia should be located. When the lesion is in its proximity, temporary insertion of a ureteric stint is advisable. Normally, the lesion will be cured

Vesicovaginal fistulas caused by abdominal hysterectomy are located high up in vagina (Table 3). The vaginal approach for repair may be possible even for high located fistulas. In developing countries, this way tends to be chosen for reasons of anesthesia and fear of postoperative intestinal problems. In the Panzi hospital material, 5 out of 11 vesicovaginal fistulas after hysterectomy were operated vaginally. The abdominal approach may be technically easier and safer, especially in cases of pelvic adhesions, and implies a possibility of interposing an omental flap between the closed bladder wall and the vaginal wall to

thermocautery is used. 3. Vaginal hysterectomy

posterior part of the pelvic floor.

paravesical space (27).

**4. Treatment**  Bladder injuries

without sequel.

reduce the risk of recurrence.

dangerous and should be preferred. When removal of the cervix is necessary endocervical palpation will to help identify the cervical edges and avoid injuries.

Conservative management of postpartum hemorrhage should be tried before hysterectomy is considered. Access to uterotonics, *iv* fluids, blood transfusion and curettage is essential. Balloon tamponade of uterus has become an important conservative method (21). A simplified condom method is useful in low-resource settings (22). The B-Lynch suture technique (23) is a effective measure to obtain compression of an atonic uterus during cesarean delivery. Cervical tears detected postpartum should be explored and sutured by the vaginal approach. In case of high tears and extrauterine hemorrhage, hysterectomy can be necessary.

A cesarean section performed late - in the second stage of labor - when the lower uterine segment is stretched and the bladder lifted high up, can easily lead to lacerations of cervix and vagina due to difficult access to the presenting part. Bleeding and difficulties may entail inappropriate suturing that can affect both the bladder and ureters, or cause inadvertent lacerations of these organs. The reversed breech extraction procedure of an entrapped fetus is a method to diminish the risk of tears and the risk of peripartum hysterectomy (24).

2. Abdominal hysterectomy

The incidence of pelvic organ fistula after hysterectomy ranges from 0.1 to 4% in different studies (25,26). A higher incidence is reported after radical hysterectomy compared with hysterectomy on benign indications. In a nationwide cohort study of 182,641 hysterectomies from Sweden, 220 urogential fistulas (0.12%) were registered. Laparoscopic hysterectomy was associated with the highest rate of fistula surgery, and subtotal abdominal hysterectomy was associated with the lowest. Risk factors are age, adhesions and postoperative infections. Risk factors for urinary tract damage are basically the same in lowresource countries as in high-resource countries. Spinal anesthesia commonly used in developing countries, gives poor relaxation. Large myomas, a common indication for hysterectomy in those areas, make access to the pelvis particularly difficult, especially when the myomas are located in the cervical part. Dislocation of organs and difficulties in identification of the bladder and ureteres increase the risk of accidental damage.

Cervical cancer is also very common in the developing world, in many countries the most common malignancy in women. This disease is most often detected in an advanced and inoperable stage. Many cancer patients undergo, however, a hysterectomy trial which, due to parametrial involvement and bleeding, ends up with a urinary tract injury. Operable (stage Ib-IIa) patients should preferably have a radical hysterectomy (a.m. Wertheim) which include proper identification and dissection of the bladder and ureteres. If this operation method is not available, or operability cannot be assured, the treatment of choice is radiotherapy with concomitant chemotherapy whenever available. Radical vaginal trachelectomy as fertility sparing operation for early stage cervical cancer has the same risk of ureteric injury as radical hysterectomy although the rate of bladder injury is higher (27).

The risk of urinary tract damage highly depends on the indication and type of intervention performed. Operations for endometriosis and malignancy (with radical hysterectomy) run a higher risk. In many cases, no predisposing factor is identified. Attempt to obtain hemostasis is the most common activity leading to injury (27). Preoperative measures like *iv*

#### Urinary Tract Injuries in Low-Resource Settings 319

pyelogram, computed tomography, prophylactic ureteric stint have not shown to be preventive. The best prevention is that the surgeon always is aware of where the ureters is and stay safely away from it and preserving its adventitial sheath. Ureter should be visualized, not only palpated. The surgeon should know well the retroperitoneal approach and use it in all difficult cases. Special care should be taken when thermocautery is used.

3. Vaginal hysterectomy

318 Hysterectomy

dangerous and should be preferred. When removal of the cervix is necessary endocervical

Conservative management of postpartum hemorrhage should be tried before hysterectomy is considered. Access to uterotonics, *iv* fluids, blood transfusion and curettage is essential. Balloon tamponade of uterus has become an important conservative method (21). A simplified condom method is useful in low-resource settings (22). The B-Lynch suture technique (23) is a effective measure to obtain compression of an atonic uterus during cesarean delivery. Cervical tears detected postpartum should be explored and sutured by the vaginal approach. In case of high tears and extrauterine hemorrhage, hysterectomy can

A cesarean section performed late - in the second stage of labor - when the lower uterine segment is stretched and the bladder lifted high up, can easily lead to lacerations of cervix and vagina due to difficult access to the presenting part. Bleeding and difficulties may entail inappropriate suturing that can affect both the bladder and ureters, or cause inadvertent lacerations of these organs. The reversed breech extraction procedure of an entrapped fetus is a method to diminish the risk of tears and the risk of peripartum hysterectomy (24).

The incidence of pelvic organ fistula after hysterectomy ranges from 0.1 to 4% in different studies (25,26). A higher incidence is reported after radical hysterectomy compared with hysterectomy on benign indications. In a nationwide cohort study of 182,641 hysterectomies from Sweden, 220 urogential fistulas (0.12%) were registered. Laparoscopic hysterectomy was associated with the highest rate of fistula surgery, and subtotal abdominal hysterectomy was associated with the lowest. Risk factors are age, adhesions and postoperative infections. Risk factors for urinary tract damage are basically the same in lowresource countries as in high-resource countries. Spinal anesthesia commonly used in developing countries, gives poor relaxation. Large myomas, a common indication for hysterectomy in those areas, make access to the pelvis particularly difficult, especially when the myomas are located in the cervical part. Dislocation of organs and difficulties in

Cervical cancer is also very common in the developing world, in many countries the most common malignancy in women. This disease is most often detected in an advanced and inoperable stage. Many cancer patients undergo, however, a hysterectomy trial which, due to parametrial involvement and bleeding, ends up with a urinary tract injury. Operable (stage Ib-IIa) patients should preferably have a radical hysterectomy (a.m. Wertheim) which include proper identification and dissection of the bladder and ureteres. If this operation method is not available, or operability cannot be assured, the treatment of choice is radiotherapy with concomitant chemotherapy whenever available. Radical vaginal trachelectomy as fertility sparing operation for early stage cervical cancer has the same risk of ureteric injury as radical hysterectomy although the rate of bladder injury is

The risk of urinary tract damage highly depends on the indication and type of intervention performed. Operations for endometriosis and malignancy (with radical hysterectomy) run a higher risk. In many cases, no predisposing factor is identified. Attempt to obtain hemostasis is the most common activity leading to injury (27). Preoperative measures like *iv*

identification of the bladder and ureteres increase the risk of accidental damage.

palpation will to help identify the cervical edges and avoid injuries.

be necessary.

higher (27).

2. Abdominal hysterectomy

Most vaginal hysterectomies are performed as part of a treatment for genital organ prolapse. Bladder and ureter injuries related to vaginal operations occur in all parts of the world. Register data from Finland showed an incidence of 0.2 bladder injuries per 1000 vaginal hysterectomies and the same incidence for ureteric injuries (1). Sixty-five percent of the complications were fistulas. In a series from France urinary tract injury occurred in 1.7% of 3076 vaginal hysterectomies - 54 bladder lesions and 1 ureteric lesion (28). It is reason to believe that the incidence of injury is higher in low-resource countries. Some institutions tend to performed hysterectomy also in cases with less pronounced genital organ prolapse. High incidence of cervical cancer and contraceptive need may be reasons for a liberal attitude to hysterectomy. However, the Manchester technique with cervical amputation is a less risky procedure. Recurrence and vault prolapsed are best prevented by building up the posterior part of the pelvic floor.

Age, parity, body weight and mode of delivery are known risk factors (1.28) and are common for low-income and high-income countries. Multiparity, poor general condition and chronic infections are more prevalent in developing countries. High bacterial content in the vagina and particular inflammatory conditions like urogenital schistosomiasis and tuberculosis may be predisposing factors. Bladder damage should be avoided by careful dissection and ureters should be localized by palpation against a metal retractor in the paravesical space (27).

## **4. Treatment**

#### Bladder injuries

Most bladder lesions are detected during the operation. The bladder wall should be closed in two layers with nonperforating, absorbable sutures and an indwelling urinary catheter for 5 days. The ureteric ostia should be located. When the lesion is in its proximity, temporary insertion of a ureteric stint is advisable. Normally, the lesion will be cured without sequel.

Vesicovaginal fistulas caused by abdominal hysterectomy are located high up in vagina (Table 3). The vaginal approach for repair may be possible even for high located fistulas. In developing countries, this way tends to be chosen for reasons of anesthesia and fear of postoperative intestinal problems. In the Panzi hospital material, 5 out of 11 vesicovaginal fistulas after hysterectomy were operated vaginally. The abdominal approach may be technically easier and safer, especially in cases of pelvic adhesions, and implies a possibility of interposing an omental flap between the closed bladder wall and the vaginal wall to reduce the risk of recurrence.

Urinary Tract Injuries in Low-Resource Settings 321 abdominal, extraperitoneal approach is normally possible and preferable. The bladder is freed from its areolar attachment in the retropubic space and an extensive mobilization (almost 270 degrees) of its ventral surface performed. The bladder is elongated toward the Psoas tendon where it is fixed. The affected ureter is freed, transected as low as possible, and the stinted proximal end is anastomozed to the elongated bladder (27). All cases of ureterovaginal fistulas reported from Panzi Hospital (Table 3) were successfully treated by

All urogenital fistulas – iatrogenic as well as obstetric ones – should preferably be treated at a specialized fistula center. It is essential that the first operation is optimally performed. The

Low-resource settings influence the risk of getting urinary tract injury as a complication to hysterectomy. Emergency peripartum hysterectomy is particularly risky and subtotal hysterectomy is a safer procedure. Postpartum hemorrhage should be managed conservatively whenever possible. Ureterovaginal and high located vesicovaginal fistulas are common sequels. These fistulas are smaller in size, have less scar tissue and appear in women with higher age and parity than the more common obstetric fistula. Repair is more often done through the abdominal route and should be performed at a specialized fistula

[1] Härkki-Sirén P, Sjöberg J, Tiitinen A. Urinary tract injuries after hysterectomy. Obstet

[2] Duong TH, Gellasch TL, Adam RA. Risk factors for the development of vesicovaginal

[3] Goodno JA, Powers TW, Harris VD. Ureteral injury in gynecologic surgery: A ten-year review in a community hospital. Am J Obstet Gynecol 1995;172(6):1817-1822. [4] Preston JM. Iatrogenic ureteric injury: common medicolegal pitfalls. Brit J Urol Int

[5] Wall LL. Obstetric vesicovaginal fistula as an international public-health problem.

[6] Muletta M, Rasmussen S, Kiserud T. Obstetric fistula in 14,928 Ethiopian women. Acta

[7] Wall LL, Karshima JA, Kirschner C, Arrowsmith SD. The obstetric vesicovaginal fistula:

[8] Savan K, Ekin M, Kupelioglu L, Oral S. Surgical repair of genitourinary fistulae:

[9] El-Lamie IK. Urogenital fistulae: changing trends and personal experience of 46 cases. Int

Urogynecol J Pelvic Floor Dysfunct 2008;19(2):267-272.

characteristics of 899 patients from Jos, Nigeria. Am J Obstet Gynecol

comparison of experience at Turkey and Niger. Arch Gynecol Obstet

fistula after incidental cystotomy at the time of a benign hysterectomy. Am J Obstet

chance of closure is greatly diminished after several attempts of repair (10).

this method of uretero-neocystostomy.

Gynecol 1998;92(1):113-118.

Gynecol 2009;201(5):512.e1-4.

Lancet 2006;368(9542):1201–1209.

Obstet Gynecol Scand 2010;89(7):945-951.

2000;86(3):313-317.

2004;190(4):1011-1019.

2010;282(6):649-653.

**5. Conclusions** 

center.

**6. References** 

Some small, vesicovaginal fistulas can be managed conservatively by bladder drainage for some weeks. Fistula surgery can be a delicate procedure and every surgeon intending to start such activity should obtain adequate training at a fistula center. Valuable handbooks are available (27,29).

Certain principles for urogenital fistula surgery prevail: 1)The tissue operated on should be without necrosis or inflammation. If operation is not done within 5 days after the injury, it is better to wait 6 weeks or more until tissue reaction is resolved. 2) All scar tissue around the fistula is removed by deliberate dissection, 3) All sutures must be tension-free. For suture technique, see fig. 1. 4) The ureteric ostiae should be visualized during the operation and, especially when the vaginal approach is used, ureteric stints applied to protect the ureters against incidental ligation or injury. 5) Postoperatively, free urine drainage must be assured for at least 2 weeks using a urethric or a suprapubic catheter. 6) Before departure, complete fistula closure is asserted by vaginal inspection after insertion of dye in the bladder

Fig. 1. Suture technique

Ureteric injuries

Ureteric occlusion should be diagnosed as early as possible before renal function is impaired. Time can be gained by temporary urinary deviation through percutaneous pyelostomy. This option is rarely available in low-resource settings. Immediate reoperation should be considered, provided the patient's general condition allows it and renal function is still possible to save. Any misplaced ligature or angulation should be removed, the viability of the ureter assessed and a stint placed through cystoscopy.

A partial transsection is repaired over a ureteral stint. Transection in upper or middle third is treated by uretero-ureterostomy over a ureteral stint. Some resection of the ureter ends can be necessary to assure viability, especially in cases of thermal injury. Spatulation of the ends is recommended to increase the lumen. The anastomosis must be completely tension free. Dissection must be done with care bearing in mind that blood supply to the ureter above the pelvic brim is coming from the medial side, below the prim from the lateral side. When the ureteric transsection took place less than 6 cm from the bladder vascularity is often impaired and primary anastomosis thereby risky. Transection of the lower third of the ureter is therefore most often treated by uretero-neocystostomy with Psoas hitch over a ureteric stint (27).

Once a ureterovaginal fistula has developed there is no longer an emergency situation. Renal function is normally not affected and a planned intervention can be performed. An abdominal, extraperitoneal approach is normally possible and preferable. The bladder is freed from its areolar attachment in the retropubic space and an extensive mobilization (almost 270 degrees) of its ventral surface performed. The bladder is elongated toward the Psoas tendon where it is fixed. The affected ureter is freed, transected as low as possible, and the stinted proximal end is anastomozed to the elongated bladder (27). All cases of ureterovaginal fistulas reported from Panzi Hospital (Table 3) were successfully treated by this method of uretero-neocystostomy.

All urogenital fistulas – iatrogenic as well as obstetric ones – should preferably be treated at a specialized fistula center. It is essential that the first operation is optimally performed. The chance of closure is greatly diminished after several attempts of repair (10).

## **5. Conclusions**

320 Hysterectomy

Some small, vesicovaginal fistulas can be managed conservatively by bladder drainage for some weeks. Fistula surgery can be a delicate procedure and every surgeon intending to start such activity should obtain adequate training at a fistula center. Valuable handbooks

Certain principles for urogenital fistula surgery prevail: 1)The tissue operated on should be without necrosis or inflammation. If operation is not done within 5 days after the injury, it is better to wait 6 weeks or more until tissue reaction is resolved. 2) All scar tissue around the fistula is removed by deliberate dissection, 3) All sutures must be tension-free. For suture technique, see fig. 1. 4) The ureteric ostiae should be visualized during the operation and, especially when the vaginal approach is used, ureteric stints applied to protect the ureters against incidental ligation or injury. 5) Postoperatively, free urine drainage must be assured for at least 2 weeks using a urethric or a suprapubic catheter. 6) Before departure, complete

Ureteric occlusion should be diagnosed as early as possible before renal function is impaired. Time can be gained by temporary urinary deviation through percutaneous pyelostomy. This option is rarely available in low-resource settings. Immediate reoperation should be considered, provided the patient's general condition allows it and renal function is still possible to save. Any misplaced ligature or angulation should be removed, the

A partial transsection is repaired over a ureteral stint. Transection in upper or middle third is treated by uretero-ureterostomy over a ureteral stint. Some resection of the ureter ends can be necessary to assure viability, especially in cases of thermal injury. Spatulation of the ends is recommended to increase the lumen. The anastomosis must be completely tension free. Dissection must be done with care bearing in mind that blood supply to the ureter above the pelvic brim is coming from the medial side, below the prim from the lateral side. When the ureteric transsection took place less than 6 cm from the bladder vascularity is often impaired and primary anastomosis thereby risky. Transection of the lower third of the ureter is therefore most often treated by uretero-neocystostomy with Psoas hitch over a

Once a ureterovaginal fistula has developed there is no longer an emergency situation. Renal function is normally not affected and a planned intervention can be performed. An

viability of the ureter assessed and a stint placed through cystoscopy.

fistula closure is asserted by vaginal inspection after insertion of dye in the bladder

are available (27,29).

Fig. 1. Suture technique

Ureteric injuries

ureteric stint (27).

Low-resource settings influence the risk of getting urinary tract injury as a complication to hysterectomy. Emergency peripartum hysterectomy is particularly risky and subtotal hysterectomy is a safer procedure. Postpartum hemorrhage should be managed conservatively whenever possible. Ureterovaginal and high located vesicovaginal fistulas are common sequels. These fistulas are smaller in size, have less scar tissue and appear in women with higher age and parity than the more common obstetric fistula. Repair is more often done through the abdominal route and should be performed at a specialized fistula center.

## **6. References**


**Part 6** 

**Hysterectomy: Multiple Aspects** 


**Part 6** 

**Hysterectomy: Multiple Aspects** 

322 Hysterectomy

[10] Elkins T. Fistula surgery: past, present and future directions. Int Urogynecol J

[11] Sjøveian S, Vangen S, Mukwege D, Onsrud M. Surgery outcome of obstetric fistula: a

[12] Onsrud M, Sjøveian S, Mukwege D. Cesarean delivery-related fistula in the Democratic

[13] Sheiner E, Levy A, Katz M, Mazor M. Identifying risk factors for peripartum cesarean hysterectomy. A population based study. J Reprod Med 2003;48:622-626. [14] Hofmeyr GJ, Say L, Gülmezoglu AM. Systematic review: WHO systematic review of

[15] Onsrud M. Changed attitude to obstetrical delivery help in Eastern Congo (in

[16] Fauveau V. Is vacuum extraction still known, taught and practiced? A worldwide KAP

[17] Sheth SS. Results of treatment of rupture of the uterus by suturing. BJOG 1968;75(1):55-

[18] Klungsøyr P, Kiserud T. Rupture of the uterus treated by suture. Acta Obset Gynecol

[19] Joshi V, Otiv S, Majumder R, Nikam Y, Shrivastava M. Internal iliac artery ligation for

[20] Khan KS, Wojdyla D, Say L, Gulmezoglu AM, Van Look PF. WHO analysis of causes of

[21] Georgiou C. Baloon tamponade in the management of postpartum hemorrhage: a

[22] Akhtar S, Begum MR, Kabir Z, Rashid M, Laila TR, Zabeen F. Use of condom to control

[23] Ferguson JE, Bourgeois FJ, Underwood PB. B-Lynch suture for postpartum hemorrhage.

[24] Chopra S, Bagga R, Keepanasseril A, Jain V, Kalra J. Disengagement of the deeply

[25] Forsgren C, Lundholm C, Johansson AL, Cnattingius S, Altman D. Hysterectomy for

[26] Forsgren C, Altman D. Risk of pelvic organ fistula in patients undergoing hysterectomy.

[27] Montz FJ, Bristow RE, Del Carmen MG. Operative injuries to the ureter. In: Rock JA,

Lippincott Williams & Wilkins, 2003:1081-1097. ISBN-10: 0781772346 [28] Mathevet P,Valencia P, Cousin C, Mellier G, Dargent D. Operative injuries during vaginal hysterectomy. Eur J Obstet Gynecol Reprod Biol 2001;97(1):71-75. [29] *First steps in vesico-vaginal fistula repair*. Hancock B, ed. London: Royal Society of

engaged fetal head during cesarean section in advanced labor: Conventional method versus reverse breech extraction. Acta Obstet Gynecol Scand

Benign Indications and Risk of Pelvic Organ Fistula Disease. Obstet Gynecol

Jones HW, eds. *Te Linde's Operative gynecology,* ninth edition. Philadelphia:

Republic of Congo. Int J Gynecol Obstet 2011;114(1):10-14.

maternal mortality and morbidity. BJOG 2005;112(9):1221-1228.

Norwegian). Tidsskr Nor Legeforen 2008;128(9):1078-1080.

arresting postpartum haemorrhage. BJOG 2007;114:356–361.

massive postpartum hemorrhage. MedGenMed 2003;5(3):38.

maternal death: a systematic review. Lancet 2006;367:1066–1074.

survey. Int J Gynecol Obstet 2006;94(2):185-189.

retrospective analysis of 595 patients. Acta Obstet Gynecol Scand 2011;90(7):753-

1997;8(1):30-35.

760.

58.

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2009;88(10):1163-1166.

2009;114(3):594-599.

review. BJOG 2009;116(6):748-757.

Obstet Gynecol 2000;95(6):1020-1022.

Curr Opin Obstet Gynecol 2010;22(5):404-407.

Medicine Press, 2005. ISBN 1-85315-611-6

**21**

 *Korea* 

**Management of Pregnancy After**

 *Department of Obstetrics and Gynecology, Hallym University,* 

Keun-Young Lee and Ji-Eun Song  *Division of Maternal-Fetal Medicine,* 

**Conization and Radical Trachelectomy**

Cervical intraepithelial neoplasia (CIN) is commonly diagnosed in women of child-bearing age. (Castle et al., 2009) The excisional treatments of CIN include cold-knife conization, laser conization, loop electrosurgical excision procedure (LEEP), and large loop excision of the transformation zone (LLETZ). CIN is also treated by ablative procedures such as laser vaporization and cryotherapy. Recently, human papilloma virus (HPV) has led to the understanding of pathogenesis and management of cervical diseases. (Moscicki et al., 2004) The screening and subsequent treatment of CIN significantly reduces the risk of invasive cervical cancer, but the impact of excisional cervical treatment on subsequent pregnancy

Many women with a diagnosis of cervical cancer are child-bearing population, younger than 40 years. Fertility-sparing radical vaginal or abdominal trachelectomy is a safe and feasible procedure for the treatment of patients with early stage cervical cancer. (Plante et al., 2005; Roman, 2005; Hertel et al., 2006) The disease-free survival rates and overall survival rates of radical trachelectomy is comparable to those of radical hysterectomy (Rob et al., 2011) The proper waiting period after radical tracelectomy and before conception varies in the literature. Roy and Plante (Roy and Plante, 1998) recommend a 6 month follow-up, while Shlaerth *et al*. (Shlaerth et al., 2003) describe a period of 1 year. The issue of having a

This chapter will outline concerns and management options of pregnancy after cervical

The important issue following cervical surgery in child-bearing age is the fertility and pregnancy outcome. Excisional cervical surgery may contribute to decreased mechanical support of cervix, and increased susceptibility to ascending infection resulting from the loss of cervical mucus. Cervical surgery may alter reproductive function by cervical shortening, impairment of immunologic defence, and alteration of cervicovaginal bacterial flora, and

pregnancy and fetal viability must be addressed following radical trachelectomy.

surgeries with conization and radical trachelectomy.

**2. Pregnancy after conization and radical trachelectomy** 

thus expose those women to high risk of preterm birth. (Svare et al., 1992)

**1. Introduction** 

outcome must be evaluated.
