*2.2.4 Cryoturbinectomy*

This method is characterized by an application on the surface of inferior turbinate of nitrous oxide for a period of 90–120 s at the −40/−80°C. The cryotherapy causes the formation intracellular of ice crystals and the demolition of cell membrane [39]. A recent paper suggests that regeneration of healthy ciliated nasal epithelium is a constant feature without evidence of scarring [40]. The efficacy on vasomotor rhinitis has been showed [39], but is not sustainable overtime [41].
