Conflict of interest

The authors declare that they have no conflicts of interest.

### Abbreviation


References

it.2017.08.005

2017.00197

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[1] Bartold PM, Mint NAS. Molecular and cell biology of healthy and diseased periodontal tissues. Periodontology 2000. 2006;40:29-49. DOI: 10.1111/

DOI: http://dx.doi.org/10.5772/intechopen.82026

[9] Müller HD, Cvikl BB, Lussi AA, Gruber RR. Mint: Salivary pellets induce a pro-inflammatory response involving the TLR4–NF-kB pathway in gingival fibroblasts. BMC Oral Health. 2016; 17(1):15. DOI: 10.1186/s12903-016-

[10] Darveau RP. Mint: Periodontitis: A polymicrobial disruption of host homeostasis. Nature Reviews.

Microbiology. 2010;(7):481-490. DOI:

[11] Preshaw PM, Taylor JJ. Mint: How has research into cytokine interactions and their role in driving immune responses impacted our understanding of periodontitis? Journal of Clinical Periodontology. 2011;38(Supp. 11): 60-84. DOI: 10.1111/j.1600-051X.

10.1038/nrmicro2337

2010.01671.x

[12] Hajishengallis G. Mint:

and host response. Trends in Immunology. 2014;35(1):3-11. DOI:

10.1016/j.it.2013.09.001

Immunomicrobial pathogenesis of periodontitis: Keystones, pathobionts,

[13] Bittner-Eddy PD, Fischer LA, Kaplan DH, Thieu K. Mint: Mucosal langerhans cells promote differentiation of Th17 cells in a murine model of periodontitis but are not required for porphyromonas gingivalis-driven alveolar bone destruction. Journal of Immunology. 2016;197(4):1435-1446. DOI: 10.4049/jimmunol.1502693

[14] Tanaka S, Nakamura K, Takahasi N,

Suda T. Mint: Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL–RANK signaling system. Immunological Reviews. 2005;208: 30-49. DOI: 10.1111/j.0105-2896.

2005.00327.x

0229-5

Immune Response in Gingival Disease: Role of Macrophage Migration Inhibitory Factor

j.1600-0757.2005.00140.x

[2] Nanci A, Bosshardt DD. Mint: Structure of periodontal tissues in health and disease. Periodontology 2000. 2006;40:11-28. DOI: 10.1111/ j.1600-0757.2005.00141.x

[3] Yucel-Lindberg T, Båge T. Mint: Inflammatory mediators in the patho genesis of Periodontitis. Expert Reviews in Molecular Medicine. 2013;15:e7

[4] Moutsopoulos NM, Konkel JE. Mint: Tissue-specific immunity at the oral mucosal barrier. Trends in Immunology. 2018;39(4):276-287. DOI: 10.1016/j.

[5] Fujita T, Yoshimoto T, Kajiya M. Mint: Regulation of defensive function on gingival epithelial cells can prevent periodontal disease. Japanese Dental Science Review. 2018;54(2):66-75. DOI:

10.1016/j.jdsr.2017.11.003

[6] Hajishengallis G. Mint: The inflammophilic character of the periodontitis-associated Microbiota. Molecular Oral Microbiology. 2014; 29(6):248-257. DOI: 10.1111/omi.12065

[7] Sochalska M, Potempa J. Mint: Manipulation of neutrophils by porphyromonas gingivalis in the development of periodontitis. Frontiers in Cellular and Infection Microbiology. 2017;7:197. DOI: 10.3389/fcimb.

[8] Bartold PM, Cantley MD, Haynes DR. Mint: Mechanisms and control of pathologic bone loss in periodontitis. Periodontology 2000. 2010;53:55-69. DOI: 10.1111/j.1600-0757.2010.00347.x
