*1.1.1.1.2 Glutathione reductase (GSH-Red)*

Glutathione reductase, a flavoprotein, catalyzes the reduction of oxidized glutathione (GSSG) to glutathione with the help of NADPH. For the successful maintenance of many antioxidant enzyme activities, it is important that glutathione stays at the reduced state [10]. Increased GSH-Red salivary concentrations have been shown to be a strong/independent prognostic indicator of the amount and extent of oxidative stress-related periodontal injury in both chronic periodontitis (CP) and aggressive periodontitis (AgP) [11].
