*1.1.1.2.1 Melatonin*

It is found in foods such as sour cherries, almonds, hazelnuts, chamomile tea, and St. John's wort [18]. Because it has lipophilic properties, melatonin can be found in almost all cells. It exerts its antioxidant effect by quenching hydroxyl and superoxide radicals. Melatonin shows strong antioxidant properties in the inflammatory process and oxidative injuries. Melatonin was found to be lower in gingival crevicular fluid and saliva of individuals with periodontitis compared to healthy individuals. It has also been reported to enhance bone formation [19, 20]. Melatonin is released with saliva to the oral cavity and protects the mucosa and gingival tissues from radical damage [21].
