**2.3 Sexual dysfunction**

The pathophysiology of sexual dysfunction in amyloidosis can range from medication side effects (corticosteroids, opioids), to primary hypogonadism (amyloid deposition in the testes), and depression. Determining the etiology of sexual dysfunction is key in selecting the proper treatment. For erectile dysfunction, sildenafil has been shown to be effective. Testosterone replacement may help in cases of hypogonadism, but has not been studied in patients with amyloidosis.
