*3.3.4 Other potential treatments*

A combination of doxycycline, which is proposed to disrupt deposited fibrillar TTR amyloid fibrils [19, 55, 70] and tauroursodeoxycholic acid (a biliary acid, and also a disrupter of nonfibrillar TTR) has been effective in removal of amyloid deposits in a mouse model [71]. Another promising approach to resolve existing amyloid deposits is targeting serum amyloid P (SAP) component, which has an avid binding to all amyloid fibril types, resulting in stabilization of the amyloid fibrils and preventing their proteolysis [72]; antibodies to SAP have been promising in animal models of amyloidosis [73], and are being investigated in different forms of human amyloidosis.
