**4.3 Liver**

The most common amyloid type in the liver is AL and leukocyte-derived chemotaxin 2 (LECT2) type [7]. LECT 2 type amyloid (ALECT2) deposition was relatively recently found within the kidney and first reported in 2008 [8]. LECT 2 is synthesized in the liver and is a chemotaxin that attracts neutrophils. Grossly, appearance ranges from normal to moderate and massive hepatomegaly. Histologically, we can see bright pink amorphous deposition within the sinusoidal space and vessel in the portal tract. AL type tends to have a sinusoidal pattern and a vascular pattern in the portal tract, but AA type shows a vascular pattern within the portal tract [9] (**Figures 3** and **4**). A globular pattern in sinusoids has been reported in LECT 2 hepatic amyloidosis [10]. Even if there are more specific patterns depending on the type, they are not accurate, and sometimes there are overlapping patterns. Thus, confirmation with a specific stain is important. Kupffer cells and Multinucleated giant cells can be seen near the amyloid deposition. If amyloid expands, it induces hepatocyte atrophy and replaces normal hepatic tissue, causing liver failure.
