**2. Epigenetic of HCC**

Epigenetic modifications are crucial in HCC. They arise in the context of known risk factors leading to chronic liver disease and concern mostly chemical alterations of DNA and histones. DNA methylation is the commonly investigated, showing its relevance in the mechanisms of gene silencing. Currently, genome-wide methylation analysis indicates important changes in the methylation status of oncogenes, signaling molecules, and suppressor genes [8]. Therefore, targeting the epigenome could lead to novel therapies of HCC.
