**5. Cytotoxic chemotherapies**

Historically, traditional chemotherapeutic agents have not shown great efficacy in the treatment of HCC when used in the advanced disease stage, in particular in case of progression after locoregional therapy. Moreover, conventional cytotoxic chemotherapies have not provided a clinical benefit or prolonged survival for patients with advanced HCC. There are limited data supporting the use of cytotoxic chemotherapies in unresectable disease, and it should be used preferably in the context of a clinical trial [78].
