Urosepsis: Flow is Life

*Nissar Shaikh, Umm-E-Amara, Jazib Hassan, Zeeshan Qazi, Arshad Chanda, Zia Mahemood, Mahommad Zubair, AR Raju Vegensa, Abdul Gafoor M. Tharayil, Adel Ganaw, Ranjan Matthias and Muna Al Musalmani*

#### **Abstract**

Urosepsis is one of the important etiological factors for community as well as hospital-acquired infections. Accordingly, urosepsis is divided into communityacquired and hospital-acquired urosepsis. Obstruction to the flow of urine is a common risk factor for community-acquired urosepsis, whereas the indwelling urinary catheter is the risk for the hospital-acquired urosepsis. *E. coli* remained the most common bacteria-causing urosepsis. If not treated early and appropriately, urosepsis can complicate into septic shock and multiple organ dysfunction. The cornerstone for the improved outcome of these patients is initial resuscitation and proper antibiotic therapy and restoring the flow of urine or removing the infected urinary catheter. Community-acquired urosepsis can be prevented by removing the obstruction to flow of urine permanently. The hospital-acquired urosepsis can be prevented by strictly following catheter-associated urinary tract infection prevention bundle and removing the catheter as early as possible.

**Keywords:** *E. coli*, microbiology, sepsis, septic shock, community-acquired and hospital-acquired urosepsis, urine obstruction, urinary catheter
