**10. Conclusion**

Sepsis is a medical emergency; urosepsis is a sepsis originating from the urinary tract. Urosepsis contributes significantly to the overall epidemiology of sepsis. The common and most frequent aetiology of urosepsis is either congenital or acquired obstruction to the flow of urine. The risk factor for urosepsis varies from metabolic diseases to the renal calculi. Based upon the environment in which the patient gets infection, urosepsis is divided into community-acquired urosepsis and hospitalacquired urosepsis. In the diagnosis of urosepsis apart from monitoring blood count, acute-phase proteins and serum lactate and blood and urinary cultures, the imaging studies play an important role. If not treated early and managed properly, urosepsis can progress into pyelonephritis, renal and prostatic abscesses and septic shock.

The cornerstones for the management of urosepsis are initial organ supportive resuscitation, appropriate early antibiotics, relieving obstruction to urinary flow and the source control. Obstruction to the urine flow is the important and most frequent factor for the urosepsis as it facilitates the bacterial growth and repeated sepsis. It is of vital importance to relieve the obstruction and restore the normal flow of urine as soon as possible to reduce the morbidity and mortality.

Prevention of urosepsis starts from well hydration to the clean genitalia, periurological procedure antibiotics, maintaining free flow of urine and strictly following the CAUTI prevention bundle in the hospitalised patients.

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