Contents

#### **Preface XI**



Chapter 7 **Possible Role of the Endocannabinoid System in Tourette Syndrome 119** Natalia Szejko, Ewgeni Jakubovski and Kirsten Müller-Vahl

#### Chapter 8 **Cannabis Use Disorder 137** Iris Balodis and James MacKillop

Chapter 9 **Bioligands Acting on the Cannabinoid Receptor CB1 for the Treatment of Withdrawal Syndrome Caused by Cannabis sativa 155** Jaderson Vieira Ferreira, Lenir Cabral Correa, Daniel Castro da Costa and Lorane Izabel da Silva Hage-Melim

Preface

*Cannabis sativa* has been used medicinally and recreationally for millennia by societies around the world; however, our comprehension of *Cannabis* and cannabinoids is still very much in its infancy. Although the field of cannabinoid research has seen incredible growth during the past three decades, many questions remain unanswered. With this book, we highlight the impressive work of some researchers in this field as they address what will become the critical scientific questions of our time concerning *Cannabis*. The book provides detailed and current reviews describing aspects of preclinical and clinical research written by experts in their re‐ spective fields. This book is highly relevant to scientists and clinicians who aim to understand

> **Dr. Willard J. Costain** Human Health Therapeutics National Research Council Ottawa, ON, Canada **Dr. Robert B. Laprairie**

College of Pharmacy and Nutrition

University of Saskatchewan Saskatoon, SK, Canada

cannabinoid pharmacology and exploit the therapeutic potential of *Cannabis*.

