**5. NMR and circular dichroism (CD) studies on the C-terminus**

Both NMR and CD studies have been performed on the C-terminus of CB1 employing peptide segments that correspond to that receptor region. Results show a helical segment resembling helix 8 that is parallel to the plane of the membrane [65–67]. Ahn et al., reported two amphipathic α-helical domains; S410-F412 that corresponds to helix 8, and a second helical segment (A440-M461) that is also parallel to the membrane, (**Figure 1**) [65].
