Preface

Chapter 7 **Possible Role of the Endocannabinoid System in Tourette**

Chapter 9 **Bioligands Acting on the Cannabinoid Receptor CB1 for the Treatment of Withdrawal Syndrome Caused by**

Chapter 10 **Pediatric Dosing Considerations for Medical Cannabis 181**

Natalia Szejko, Ewgeni Jakubovski and Kirsten Müller-Vahl

Jaderson Vieira Ferreira, Lenir Cabral Correa, Daniel Castro da Costa

Jane Alcorn, Stephanie Vuong, Fang Wu, Blair Seifert and Andrew

Richard James Huntsman, Richard Tang-Wai and Jose Tellez-

**Syndrome 119**

**VI** Contents

Chapter 8 **Cannabis Use Disorder 137**

Lyon

Zenteno

**Cannabis sativa 155**

Iris Balodis and James MacKillop

and Lorane Izabel da Silva Hage-Melim

Chapter 11 **Cannabis for Pediatric and Adult Epilepsy 201**

*Cannabis sativa* has been used medicinally and recreationally for millennia by societies around the world; however, our comprehension of *Cannabis* and cannabinoids is still very much in its infancy. Although the field of cannabinoid research has seen incredible growth during the past three decades, many questions remain unanswered. With this book, we highlight the impressive work of some researchers in this field as they address what will become the critical scientific questions of our time concerning *Cannabis*. The book provides detailed and current reviews describing aspects of preclinical and clinical research written by experts in their re‐ spective fields. This book is highly relevant to scientists and clinicians who aim to understand cannabinoid pharmacology and exploit the therapeutic potential of *Cannabis*.

> **Dr. Willard J. Costain** Human Health Therapeutics National Research Council Ottawa, ON, Canada

**Dr. Robert B. Laprairie** College of Pharmacy and Nutrition University of Saskatchewan Saskatoon, SK, Canada

**Section 1**

**Introduction**

**Section 1**
