**Meet the editors**

Dr. Willard J. Costain leads a team of researchers focused on developing biologic therapeutics for central nervous system diseases. His primary interest is in characterizing the pharmacology and signaling mechanisms of small and large molecule therapeutics. He studies G-protein-coupled receptor systems using a variety of techniques, with a recent focus on synthetic cannabinoid pharmacology.

Dr. Robert B. Laprairie's research focuses on drug structure-activity relationships at the type 1 cannabinoid receptor (CB1R) and has published over 30 peer-reviewed publications in this area. He is cochair of the Cannabinoid Research Initiative of Saskatchewan and the Canadian Consortium for the Investigators of Cannabinoids.

Contents

**Preface VII**

**Section 2 Pre-Clinical Research 9**

**Structures 33**

**Section 3 Clinical Research 81**

Lee Ellis

Chapter 1 **Introduction to Recent Advances in Cannabinoid Research 3**

Chapter 2 **Zebrafish as a High-Throughput In Vivo Model for Testing the**

Rufaida Al-Zoubi, Dow P. Hurst and Patricia H. Reggio

Chapter 4 **Quality Traits of Medical Cannabis sativa L. Inflorescences and**

**Derived Products Based on Comprehensive Mass-Spectrometry**

Lorenzo Calvi, Radmila Pavlovic, Sara Panseri, Luca Giupponi,

**Cannabis Phytochemicals on the Brain and Cognition 83**

Chapter 6 **Modulation of Pain by Endocannabinoids in the Periphery 101** Megan L. Uhelski, Iryna Khasabova and Donald A. Simone

Robert B Laprairie and Will Costain

**Bioactivity of Cannabinoids 11**

**Analytical Investigation 55**

Katrina Weston-Green

Valeria Leoni and Annamaria Giorgi

Chapter 5 **The United Chemicals of Cannabis: Beneficial Effects of**

Chapter 3 **Structural Insights from Recent CB1 X-Ray Crystal**

**Section 1 Introduction 1**
