*5.2.5 VD pleiotropy after KT: NODAT*

The major risk factors for NODAT are use of steroids and calcineurin inhibitors. The data for VD-NODAT association are insufficient. The trial VITALE is to assess the effect of high and low doses cholecalciferol in VD–insufficient KTRs on NODAT prevalence [96].

## *5.2.6 VD pleiotropy after KT: cardiovascular disease*

Marchal et al. established a significant association between lower 25VD and vascular calcification after KT [85]. However, a more recent study did not find a relationship between VD status and post-transplant hypertension and major CV events [97]. One of the aims of the already mentioned trial VITALE is to assess the effect of cholecalciferol supplementation on blood pressure control and CVD rates in KTRs [96].
