**Author details**

Ildiko Bodi1 \*, Krisztina H.-Minko1 , Zsolt Prodan<sup>2</sup> and Imre Olah1


\*Address all correspondence to: bodi.ildiko@med.semmelweis-univ.hu

© 2019 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**19**

*Compartmentalization of Human Thymic Medulla: Facts and Hypotheses*

[10] Kendall MD. The morphology of perivascular spaces in the thymus.

[11] Savino W, Carnaud C, Luan JJ, Bach JF, Dardenne M. Characterization of the extracellular matrix-containing giant perivascular spaces in the NOD mouse thymus. Diabetes.

[12] Mori K, Itoi M, Tsukamoto N, Kubo H, Amagai T. The perivascular space as a path of hematopoietic progenitor cells and mature T cells between the blood circulation and the thymic parenchyma. International Immunology. 2007;**19**:745-753

[13] Bryson JL, Griffith AV, Hughes B, Saito F, Takahama Y, Richie ER, et al. Cell-autonomous defects in thymic epithelial cells disrupt endothelialperivascular cell interactions in the mouse thymus. PLoS One.

2013;**4**(8):e65196. DOI: 10.1371/journal.

Thymus. 1989;**13**:157-164

1993;**42**:134-140

pone.0065196

2001;**103**:141-143

1972;**136**:466-498

[14] Gordon J, Bennett AR, Blackburn CC, Manley NR. Gcm2 and Foxn1 mark early parathyroidand thymus-specific domains in the developing third pharyngeal pouch. Mechanisms of Development.

[15] Gallo V, Cirillo E, Giardino G, Pignata C. FOXN1 deficiency: From the discovery to novel therapeutic approaches. Journal of Clinical Immunology. 2017;**37**:751-758. DOI:

[16] Raviola E, Karnovsky MJ. Evidence for a blood-thymus barrier using electron-opaque tracers. The Journal of Experimental Medicine.

Dardenne M. Studies on the thymus in

10.1007/s10875-017-0445-z

[17] W S, Boitard C, Bach JF,

*DOI: http://dx.doi.org/10.5772/intechopen.88588*

[1] Minkó K, Oláh I. Expression of intermediate filaments and N-cadherin adhesion molecule in the thymus of domesticated birds. Acta Biologica Hungarica. 1996;**47**:323-340

**References**

[2] Bódi I, Minkó K, Molnár D, Nagy N, Oláh I. A novel aspect of the structure of the avian thymic medulla. Cell and Tissue Research. 2015;**359**:489-501. DOI: 10.1007/s00441-014-2027-1

Greiner DL, et al. Defects in the thymic epithelial stroma of diabetes prone BB

[3] Rozing J, Coolen C, Tielen FJ, Weegenaar J, Schuurman HJ,

rats. Thymus. 1989;**14**:125-135

[4] Godfrey DI, Izon DJ, Tucek TC, Wilson TJ, Boyd RL. The phenotypic heterogeneity of mouse thymic stromal cells. Immunology. 1990;**70**(1):66-74

[5] Schuurman HJ, van Loveren H, Rozing J, van Dijk A, Loeber JG, Vos JG. Cyclosporin and the rat thymus. An immunohistochemical study. Thymus.

[6] García-Ceca J, Montero-Herradón S, Alfaro D, Zapata AG. Increased epithelialfree areas in thymuses with altered EphBmediated thymocyte-thymic epithelial cell interactions. Histochemistry and Cell Biology. 2017;**148**:381-394. DOI: 10.1007/

[7] Bruijntjes JP, Kuper CF, Robinson JE, Schuurman HJ. Epithelium-free area in the thymic cortex of rats. Developmental

[8] Bódi I, Minkó K, Prodán Z, Nagy N, Oláh I. Structure of the thymus at the beginning of the 21th century. Orvosi

development of the human thymus microenvironment. Current Topics in

Immunology. 1993;**3**:113-122

Hetilap. 2019;**160**:163-171

[9] von Gaudecker B. The

Pathology. 1986;**75**:1-41

1990;**16**:235-254

s00418-017-1583-3

*Compartmentalization of Human Thymic Medulla: Facts and Hypotheses DOI: http://dx.doi.org/10.5772/intechopen.88588*
