**5.1 Intestinal DCs and macrophage subsets**

Dendritic cells (DCs) subsets, which differentiated from ILC bundle, perform compounded roles in final outcome in the immune responses. In the gut, DCs handshake many exogenous antigenic pathogen to prevent infections [64]. The intestine DCs and amended Mϕ appears to be indispensable in the instigation of active immunity and homeostasis in the gut. These cells have unique ability to rove through the goats mesenteric lymph nodes (MLNs) to perform key start of naïve T cells priming for adaptive immune response [65]. These intestinal DCs and Mϕs within the lamina propria perform vital steps in the initiation, development and regulation of specific intestinal immunity [66]. Most naïve T cells mature up in peripheral lymphoid organs. These cells get expression activation through gut-associated lymphoid tissues (GALTs). In goats, Peyer's patches and mesenteric lymph nodes (MLNs) act as hub of transformation of the CD 4 T and CD 8αβ T cells which in turn prime the antigen-presenting cells (APCs) [67]. The lymphoid associated organs attain the ability to transfer to intestinal area with specific gut homing molecule, integrin α4β7, by its upregulation and others [68].
