**1. Introduction**

Translational science provides the opportunity to apply advances in science directly to patient care. In oncology, new and important scientific information is moving forward at an enterprise level. Managing data for translational science requires a sophisticated informatics infrastructure that can harmonize multiple datasets on subjects in all areas that influence outcome. Medical history, stage of disease, disease location, surgery, pathology genomic/proteomics imaging, radiation therapy, and medical oncology are equally important in determining outcome both in tumor control and normal tissue function post-therapy. In this chapter, we describe opportunities moving forward to enhance our knowledge and application of science to patient care.
