**Abstract**

Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in the production of insulin by the pancreas, or by ineffectiveness of the insulin produced. Diabetes is a life-long disease marked by elevated levels of sugar in the blood. It is considered as the second progressing cause of color blindness and kidney defects throughout the world. There are four times higher chances of getting heart disease and strokes suffering with diabetes than other ailments. Type-2 diabetes has approximately 90% cases in Pakistan and need to be checked out for its therapy. Olive oil could be helpful in diabetes via many of ways, as prolonged inflammation plays a role as an enhancer of diabetes and other diabetes problems. This study reports identification of some of the cheapest ways to lower the cholesterol in the diabetes mellitus in the local population by using advanced technologies. In this work, the main focus of the research was to use olive oil as a therapy, and as a lipid lowering agent, to improve and reduce the chance of blood pressure, lipids, and hence diabetes and cardiovascular diseases.

**Keywords:** in silico, EVOO, diabetes, proteomic, dyslipidemia

#### **1. In silico proteomics**

Bioinformatics is a science of intellectual biology with respect to molecule recognition as it uses informatics principles to sort out the information of molecules on large scale. Applied math, statistics and computer laid down its foundation. In simple words, bioinformatics work as a platform for management of data in molecular biology field. It has many other applications too in molecular biology [1].

Bioinformatics has many applications in different fields of biology like genomics, biotechnology, molecular biology, and many areas of biomedical sciences. For instance, it is used in DNA fingerprinting, agriculture and drug designing approaches [1]. Drug designing is done in silico by the comparative association of ligand protein interactions; leads obtained this way provide innovative medicines. This type of association is the base of synthetic drug designing. The 3-D structure of proteins is studied via pyMOL or VMD softwares. These softwares clearly demonstrate the receptor ligand relationship in drug designing process. The drug developed by this way requires less budget with greater efficiency and less or no harmful side effects. Drug development is done utilizing informatics principles (Lagunin *et al.*, 2014).

Now a days criminal are captured by using bioinformatics tools like phylogenetic analysis provide a proof against the criminal in court of law. In forensic analysis Bayesian statistics are utilized to detect DNA of culprit [2]. Bioinformatics has made of healthcare system modernize with the introduction of personalized drugs etc. [3].

**1.1** *In silico* **drug designing**

*DOI: http://dx.doi.org/10.5772/intechopen.82294*

(Grinter and Zou, 2014).

method, those includes;

• Grid computing

• Python and Perl

• PKUDDS

• JAVA

• APIS

• MEGA

**Figure 1.**

**65**

*In silico drug designing.*

• Clustal W

• PBPK/PD modeling software

and Zou, 2014).

Discovery of new drug is lengthy and expensive process and require lots of mass efforts too. Many of the times the year's hard work in drug discovery is wasted away due to certain factors like toxic effects, poor drug metabolism etc. (Grinter

*In Silico Proteomics EVOO Therapy for Lipid Lowering in the Patients of Diabetes Mellitus*

So with the advancement in the field of informatics, the drug discovery process has been completely changed as drugs are developed in silico with the help of latest Bioinformatics tools and applications. Today many fields use in silico drug designing (**Figure 1**) method like biochemistry, nanotechnology and molecular biology. This method has major advantage on others is its cost effectiveness and quickness

Many outstanding tools and softwares are used for drug development by in silico

Now it has become possible with the advancement in the knowledge of bioinformatics that genetic defects are pin pointed on time and are tried to be eliminated before their expression. In this way better treatment has become possible in this era (Takeichi *et al.*, 2015). Bioinformatics has revolutionized the agriculture system with the introduction of new and better crops varieties with increased production potential and resistant against crop damaging agents (Katam *et al.*, 2015).

Bioinformatics is not only limited to Allied health fields but it is also play important role in many other fields too as given below;


*In Silico Proteomics EVOO Therapy for Lipid Lowering in the Patients of Diabetes Mellitus DOI: http://dx.doi.org/10.5772/intechopen.82294*
