Preface

This book provides an overview of the analysis of blood, serum, plasma, urine, and tissues for a wide variety of substances such as substrates, enzymes, and hormones, and their use in diagnosis and monitoring of disease. The content provides qualitative and quantitative analysis of these biological fluids with their specific chemical constituents or physiologic processes.

The first chapter by Drs. Satish Ramanathan and Chakravarthy Narasimhachar Srinivas emphasizes the use of electrophoresis as an aid in diagnosing clinical conditions such as acute and chronic inflammations and various other diseases. Serum protein electrophoresis, which separates serum proteins into various fractions based on their molecular weight and electric charges, can provide specific measurements of various serum proteins such as alpha-1 antitrypsin (AT), alpha-1-chymotrypsin, thyroid-binding globulin, alpha-2 macroglobulin, haptoglobin, ceruloplasmin, transferrin, low-density lipoprotein, and immunoglobulins (IgG, IgA, IgM, IgD, and IgE) for diagnostic purposes.

The chapter by Husniza Hussain, Rusidah Selamat, Lim Kuang Kuay, Fuziah Md Zain, and Muhammad Yazid Jalaludin highlights the importance of urinary iodine measurement in diagnosing disease related to this marker.

The chapter by Khushaboo Pandey and Om Prakash Mishra Apart discusses sample analysis, collection, storage, and preparation. It also discusses various spectrophotometry, sensors, and chromatographic techniques.

The chapter by Nataša Gros covers the quality of blood collection tubes and examines the differences in tube characteristics of different brands and different lots. Because the tubes' attributes change over their shelf life, the author suggests fast, easy-toperform testing procedures using purified water and low-cost equipment.

The chapter by Samreen Riaz and Muhamamd Sohail examines the use of extra virgin olive oil in reducing lipid profile in diabetes. It reports that this activity may be due to the oil's antioxidants. The authors use in silico bioinformatic analysis to screen and check the therapeutic potential of this plant.

The chapter by Zilton Vasconcelos, Renata Campos Azevedo, Andrea Zin, Luiza Neves, and Daniela Prado Cunha explores the advancement of serological diagnostic tools for Zika virus. Reverse transcriptase real-time PCR is suggested as the most reliable tool for Zika virus infection diagnosis. It detects viral RNA in both biological fluids and tissues and contributes to clinical case classification for initial description of developmental changes observed in neonates exposed congenitally to Zika virus.

A detail protocol of standardized hemolytic assay AP100 was elaborated in a chapter on Semi-Solid Phase Assay for Alternative Pathway Activity Assessment. The authors aimed to assist laboratories in the developing and low incomes countries by using this assay. The procedure is essentially the same as AP50 except the two items mentioned in the book chapter. The chapter by Kheir Eddine Kerboua emphasizes

**II**

**Chapter 9 135**

Resource-Based View of Laboratory Management: Tissue Bank ATMP

*by Wojciech Smętek, Jacek Węgrzyk, Agnieszka Klama-Baryła, Wojciech Łabuś, Małgorzata Kraut, Michał Szapski, Mariusz Nowak* 

Production as a Model

*and Diana Kitala*

the many advantages of AP100 over AH50, where AP100 has at least nine applications in disease diagnosis and follow-up.

The chapter by Yana Sandlers gives an overview of amino acid metabolism-related inherited disorders. It presents amino acid analysis for the diagnosis and routine monitoring of this category of inborn errors of metabolism.

Finally, the chapter by Wojciech Smętek, Jacek Węgrzyk, Agnieszka Klama-Baryła, Wojciech Łabuś, Małgorzata Kraut, Michał Szapski, Mariusz Nowak, and Diana Kitala discusses the importance of performing good quality control in accordance to good manufacturing practice to produce high-quality, advanced therapy medicinal products.

The Editors would like to acknowledge all chapter contributors for their excellent pieces of writing and IntechOpen for publishing this book.

> **Varaprasad Bobbarala** Adhya Biosciences, India
