**4. Final remarks**

Next-generation domestication: in the age of big data, gene editing, and next generation sequencing (NGS), we have the opportunity to document the transition from wild plant to crop. NGS provides a powerful tool for discovery of domestication genes in crop plants and their wild relatives [55]. The accelerated domestication of new plant species as crops may be facilitated by this knowledge. Re-sequencing of domesticated genotypes can identify regions of low diversity associated with domestication. Novel allelic variation in close or distant relatives can be characterized by NGS; the results give support to the selection and adaptation as new crops and ensure that biomass with therapeutic efficacy will be obtained. The characterization and evaluation of these model species have a phase of construction and validation of genomic cDNA expression libraries with the objective to accelerate the domestication of forest trees in a changing world. This strategy has allowed us to propose plans and technological processes to improve the quality of life in rural territories and to support sustainable growth of wild plant populations and their ecosystem.
