*Edited by Andrei Surguchov*

Neurodegenerative diseases are debilitating conditions that result in degeneration and death of nerve cells. A significant group of these diseases is the synucleinopathies, which are characterized by the accumulation of aggregates of alpha-synuclein in neurons, nerve fibers, or glial cells. There are three main types of synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Synucleins are small, naturally unfolded proteins prone to aggregate and form intracellular inclusions, which impair normal cellular functions. This book presents new data on synuclein aggregation and its effect on cholesterol transport. It also discusses the role of genetic contribution to these diseases and approaches to inhibition of synuclein aggregation.

ISBN 978-1-78984-565-5

Synucleins - Biochemistry and Role in Diseases

Published in London, UK © 2020 IntechOpen © nnorozoff / iStock

## Synucleins Biochemistry and Role in Diseases

*Edited by Andrei Surguchov*

## Synucleins - Biochemistry and Role in Diseases

*Edited by Andrei Surguchov*

Published in London, United Kingdom

### *Supporting open minds since 2005*

Synucleins - Biochemistry and Role in Diseases http://dx.doi.org/10.5772/intechopen.73750 Edited by Andrei Surguchov

#### Contributors

Jasmina Dragan Dimitrova-Shumkovska, Ljupcho Krstanoski, Hayate Javed, Shreesh Ojha, Nevra Alkanli, Arzu Ay, Nitesh Poddar, Sheeza Khan, Muhammad Daniyal, Muhammad Akram, Aatiqa Ali, Andrei Surguchov

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First published in London, United Kingdom, 2020 by IntechOpen IntechOpen is the global imprint of INTECHOPEN LIMITED, registered in England and Wales, registration number: 11086078, 7th floor, 10 Lower Thames Street, London, EC3R 6AF, United Kingdom Printed in Croatia

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Synucleins - Biochemistry and Role in Diseases Edited by Andrei Surguchov p. cm. Print ISBN 978-1-78984-565-5 Online ISBN 978-1-78984-588-4 eBook (PDF) ISBN 978-1-78984-589-1
