**2. Conclusion**

Investigations done on antioxidants have shown that these compounds are candidates for the treatment and candidates to prevent oxidative stress-related diseases. This chapter focuses on antioxidants that can be investigated in experimental and clinical trials of many diseases but especially in diseases of liver. Main nutritional components involved in the production and/or removal of free radicals and the role of free radicals in the pathogenesis of several hepatic diseases and related comorbidities have been described in this chapter.

Among the antioxidants that were described, curcumin, naringenin, and quercetin have been found to be effective antioxidants in treatment of experimental liver injury. Green tea has been shown to protect against different kinds of cancer in clinical trials but not on hepatocellular carcinoma. Resveratrol has been extensively studied in experimental models of liver diseases and has been shown to have protective effects on fibrosis. So far, there are not much clinical trials on ameliorating and disease preventing effects of most potent antioxidants on liver and these antioxidants are good candidates for clinical trials not only because they show great disease preventing and ameliorating effects but also because they are derived from food sources and have a good metabolic tolerance.
