**Author details**

Ovidiu Balacescu1,2\*, Simona Visan1 , Oana Baldasici1,3, Loredana Balacescu1,2, Catalin Vlad4,5 and Patriciu Achimas-Cadariu4,5

1 Department of Functional Genomics, Proteomics and Experimental Pathology, The Oncology Institute "Prof. Dr. Ion Chiricuta", Cluj-Napoca, Romania

2 Department of Medical Oncology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania

3 Faculty of Pharmacy, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania

4 Department of Surgical and Gynecological Oncology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania

5 Department of Surgery, The Oncology Institute "Prof. Dr. Ion Chiricuta", Cluj-Napoca, Romania

\*Address all correspondence to: obalacescu@yahoo.com

© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

**51**

*MiRNA-Based Therapeutics in Oncology, Realities, and Challenges*

[11] Krek A, Grun D, Poy MN, Wolf R,

[12] Coronnello C, Benos PV. ComiR: Combinatorial microRNA target prediction tool. Nucleic Acids Research. 2013;**41**(Web Server issue):W159-W164

[13] Friedman Y, Karsenty S, Linial M. miRror-suite: Decoding coordinated regulation by microRNAs. Database (Oxford). 6 Jun 2014;**2014**:pii:bau043.

DOI: 10.1093/database/bau043

[14] Kozomara A, Griffiths-Jones S. miRBase: Annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Research. 2014;**42**(Database issue):D68-D73

[15] Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 2002;**99**(24):15524-15529

[16] Cimmino A, Calin GA, Fabbri M, Iorio MV, Ferracin M, Shimizu M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proceedings of the National Academy of Sciences of the United States of America. 2005;**102**(39):13944-13949

[17] Calin GA, Liu CG, Sevignani C, Ferracin M, Felli N, Dumitru CD, et al. MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proceedings of the National Academy of Sciences of the United States of America. 2004;**101**(32):11755-11760

[18] Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, et al.

Rosenberg L, Epstein EJ, et al. Combinatorial microRNA target predictions. Nature Genetics.

2005;**37**(5):495-500

*DOI: http://dx.doi.org/10.5772/intechopen.81847*

[1] Society AC. Global Cancer Facts & Figures. 3rd ed. Atlanta: American

[2] Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer.

Cancer Society; 2015

**References**

2015;**136**(5):E359-E386

2009;**9**(4):265-273

[3] Chaffer CL, Weinberg RA. A perspective on cancer cell metastasis. Science. 2011;**331**(6024):1559-1564

[4] Hanahan D, Weinberg RA. Hallmarks of cancer: The next

generation. Cell. 2011;**144**(5):646-674

[5] Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits. Nature Reviews. Cancer.

[6] Jolly MK, Tripathi SC, Somarelli JA, Hanash SM, Levine H. Epithelial/ mesenchymal plasticity: How have quantitative mathematical models helped improve our understanding? Molecular Oncology. 2017;**11**(7):739-754

[7] Pennisi E. Genomics. ENCODE project writes eulogy for junk

[8] Ambros V. The evolution of our thinking about microRNAs. Nature Medicine. 2008;**14**(10):1036-1040

[10] Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets.

[9] Kim VN, Han J, Siomi MC. Biogenesis of small RNAs in animals. Nature Reviews. Molecular Cell Biology.

2009;**10**(2):126-139

Cell. 2005;**120**(1):15-20

DNA. Science 2012;**337**(6099):1159-1161

*MiRNA-Based Therapeutics in Oncology, Realities, and Challenges DOI: http://dx.doi.org/10.5772/intechopen.81847*
