Meet the editors

Dr. Shashwat Sharad is Assistant Professor and Staff Scientist at the Center for Prostate Disease Research, Uniformed Services University–Walter Reed Surgery, USA. He is a member of the John P. Murtha Cancer Center at Walter Reed. For decades, he dedicated his research efforts to addressing molecular genetic alterations in prostate cancer with emphasis on translating new information for the benefit of patients. His current research

focuses on (1) defining prostate cancer-specific gene and protein alterations and hormonal mechanisms through evaluations of prostate cancer genome, transcriptome and proteome and cancer biology approaches; and (2) developing/evaluating new technologies for improving diagnosis, prognosis and treatment of prostate cancer. He played a key role in the successful outcome of a multidisciplinary translational research effort between urologists, cancer biologists, pathologists, epidemiologists, and bio and medical informaticians. This synergy has been highlighted by several publications. Dr. Sharad is a biomedical translational researcher with a strong academic/administrative track record. He is the recipient of several research fellowships and grant awards. He has published various manuscripts, review articles, book chapters and conference proceedings. Several students, fellows and residents trained by him have gone on to make excellent careers for themselves. He actively serves as an editorial board member and reviewer for leading journals. He made a great impact on science by contributing to developing the technology for the point-of-care device, RightBiotic: The Fastest Antibiotic Finder.

Dr. Suman Kapur is Senior Professor and Dean at the Birla Institute of Technology and Science (BITS) Pilani, Hyderabad Campus. Her research interests include genetic markers for vulnerability to chronic human diseases, screening strategies for low-cost settings, medical devices for field deployment in low-resource settings, and disease prevention through natural products. Dr. Kapur has received several awards and has been

honored by Government of India as a Women Achiever in the field of Science and Technology. She holds several patents, has published and/or edited several books, has published more than 200 peer-reviewed scientific articles, has delivered more than 220 invited/keynote lectures, and has organized several scientific meetings, workshops, and dedicated trainings. Dr. Kapur is also an entrepreneur and has a startup that strives to provide affordable healthcare for all. She is the recipient of several awards including the Marico Foundation "Innovate for India Award," the Ricoh Education Foundation "Innovation Ninja Award," and a Photon Research Award for her work in antimicrobials. She is an expert member on several panels related to stem cell therapeutics, functional foods and nutraceuticals (FSSAI), standards for food and water requirements during disaster management (NDMA), and jury member for several award committees for awards in science.

Contents

Antisense Therapy: An Overview

*by Sara Karaki, Clément Paris and Palma Rocchi*

*by Ovidiu Balacescu, Simona Visan, Oana Baldasici,* 

Oncoproteins Targeting: Antibodies, Antisense,

Therapeutic Implication of miRNA in Human Disease *by Andrew Walayat, Meizi Yang and DaLiao Xiao*

*by Behiye Şenel and Gülay Büyükköroğlu*

*by Shashwat Sharad*

*by Jerzy Trojan*

**Preface III**

**Chapter 1 1**

**Chapter 2 13**

**Chapter 3 31**

**Chapter 4 59**

**Chapter 5 77**

**Chapter 6 93**

Applications of Lipidic and Polymeric Nanoparticles for siRNA Delivery

Antisense Oligonucleotides, A Novel Developing Targeting Therapy

MiRNA-Based Therapeutics in Oncology, Realities, and Challenges

*Loredana Balacescu, Catalin Vlad and Patriciu Achimas-Cadariu*

Triple-helix. Case of Anti IGF-I Cancer Immunogene Therapy
