Contents


Preface

Antisense therapy, or oligotherapy, is an emerging field of disease treatment and a revolution that has completely changed gene therapy. Antisense oligonucleotides are small synthetic fragments of DNA that have potential to target and bind to messenger RNA of a particular gene causing a particular disease, and modulate specific protein production in human genome. Antisense therapy using oligonucleotides has many applications in clinical medicine and has great potential to change the therapeutic landscape for many disease conditions, including their prevention, treatment, and management. This book presents oligonucleotides as an important therapeutic option and discusses how they may be used to treat cancer and other diseases. It not only covers important developments in the field of molecular mechanisms, but also highlights novel therapeutic approaches in several human disorders including cancer. There was a need to bring this information together in a single volume, as much of the recent developments are dispersed throughout

It is my hope that readers will appreciate the complexity of oligonucleotides research, especially for healthcare treatment. In the era of precession medicine, targeted therapy plays an important role. Identifying disease-specific molecular changes and targets for precision treatment is critical. In theory, oligonucleotides are designed to control the transfer of genetic information, but the use of antisense therapy is likely to benefit the patient and help manage disease. This book summarizes the current state of the field of oligo-based therapy in cancer and is an ideal resource for clinicians and researchers interested in antisense therapy. It will also appeal to physicians, surgeons, residents, biomedical scientists, and students.

**Shashwat Sharad, Ph.D.** 

Department of Surgery,

Bethesda, Maryland, USA

Bethesda, Maryland, USA

**Suman Kapur, Ph.D.** Senior Professor,

Center for Prostate Disease Research,

Department of Biological Sciences and Dean,

Birla Institute of Technology and Science, Pilani Hyderabad Campus, Telangana, India

Uniformed Services University of Health Sciences (USU) and Walter Reed National Military Medical Center (WRNMMC),

Henry Jackson Foundation for the Advancement of Military Medicine,

International Programmes and Collaboration Division (University wide),

biomedical literature, largely in specialized journals.
