**Abstract**

Pathogenic *Escherichia coli* constitute an important current problem of public health and animal production. Efforts have been made to fight the infections caused by these bacteria, and in this chapter, we present the progress made up to date in the vaccines generated for this purpose. Different vaccines have been tested against the pathotypes responsible for human diseases such as diarrhea and urinary infections. Also, the poultry market has deserved the effort of the researchers to obtain a product that fights the *E. coli* strains that cause diseases in them. Finally, advances are also presented for the zoonotic enterohemorrhagic *E. coli* (EHEC), which are a different problem due to their low importance as a disease factor in cattle, but they are a very important pathogen in humans. In several of these fields, authorized products have been developed and are currently being marketed.

**Keywords:** pathogenic *Escherichia coli*, vaccine, human, cattle, virulence factors
