**9. Conclusion**

Biogenics is based on the concept of using the active ingredients which were revealed by the mechanism of oral probiotics. Biogenics is expected to be a prevention method for oral diseases that can be implemented without the problems associated with the use of probiotic bacteria, namely the involvement of acids harmful to teeth. The emergence of resistant bacteria against naturally occurring substances of biogenic candidates is not yet known. Furthermore, it is possible to combine substances which contribute to the health of the oral cavity, with those contributing to systemic health, such as control substances for blood sugar level, blood pressure, neutral fat, antioxidants, anti-stress, immune enhancement, anti-inflammation, antianxiety, and antidepressants. Therefore, the progress of practical application is expected. However, the elucidation of the mechanism of action is still in the beginning, and further study is needed.
