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**10** 

*China* 

**Hepatocellular Carcinoma: Insights** 

**from the Centrosome Abnormalities** 

*1School of Life Science and Technology, Henan Institute of Science* 

*2Shandong Lanjin Pharmaceuticals Co., LTD, Jinan Hi-tech Zone,* 

Hepatocellular carcinoma (HCC) ranks the third in cancer-related death in the world. In Africa and Asia, the incidence of HCC, and death rate in particular, is even higher than other types of cancer. Chronic inflammation, mainly caused by viruses such as hepatitis B virus (HBV) and hepatitis C virus (HCV), has long been regarded as the major player in HCC development. However, increasing genes and/or tremendous epigenetic factors, and interactions thereof, have appeared to be involed in HCC development (Beasley & Lin, 1978; Arbuthnot & Kew, 2001). Although great efforts have been made in the past, early diagnosis and effective treatment to the patients in the late stage are still difficult. Centrosome amplification, a distinct feature in most cancer cells, has been widely studied recently in leukemia and increasing types of solid tumors. In HCC, however, there are few studies reported. What roles may centrosome play in hepatocellular carcinoma? What insights may it shine in guiding cancer therapies? And so on. We, in this chapter, would like to discuss the relations between centrosome and HCC development, through which, hopefully, novel therapeutic approaches are developed based on targeting the centrosome as a whole instead

Centrosomes are tiny complex organelles, near the nucleus of an interphase cell, serving as microtubule organizing center (MTOC) involved in fundamental cellular activities such as cell polarity, cellular adhension, mobility, signal and molecule transport. These cellular processes are inseparable with important cellular events, such as cell cycle, DNA synthesis, DNA repair, apoptosis regulation, signal transduction, and carcinogenesis (Whitehead & Salisbury, 1999; Rieder et al., 2001; Palazzo et al., 2000). When cell enters into M phase, two newly duplicated centrosomes move to the opposing sites and form the poles of the mitosis spindle. Mitosis spindle play key roles in maintaining genetic stability, with the roles of centrosome in carcinogenesis having long been noticed by Theodor Boveri (Boveri T, 1914). Recently the centrosome was even described as a core part of "cell brain" (Kong et al., 2002).

**1. Introduction** 

of just some proteins on it.

**2. Centrosome in cancer** 

Ying Chen1 and Qingzhong Kong2

*Jinan City, Shandong Province* 

*and Technology, Xinxiang City, Henan Province* 

