Contents

#### **Preface XIII**

	- **Part 2 Carcinogenesis / Invasion / Metastasis 101**

Contents VII

Chapter 17 **Use of a Human–Derived Liver Cell Line for** 

Chapter 18 **Reviews on the Epidemiology, Quality of Life,** 

Elegance T.P. Lam and Cindy L.K. Lam

Paloma Morales and A.I. Haza

**the Detection of Protective Effect of Dietary Antioxidants Against Food Mutagens 357** 

**and Management of Chronic Hepatitis B (CHB) 373** 

	- **Part 3 Detection / Prevention / Prevalence 325**

Chapter 17 **Use of a Human–Derived Liver Cell Line for the Detection of Protective Effect of Dietary Antioxidants Against Food Mutagens 357**  Paloma Morales and A.I. Haza

VI Contents

Chapter 7 **Tissue Factor Pathway Inhibitor-2 Inhibits the Growth** 

Yong Xu, Xiaolin Qin, Jinjing Zhou, Zhiguang Tu, Xiao Bi, Wuxian Li, Xiaoqing Fan and Yi Zhang

**Hepatocellular Carcinoma: An Update 171**

**from the Centrosome Abnormalities 219** 

**Cancer Stem Cells: Implication in Metastasis 235** Yasufumi Omori, Yohei Kawasaki, Qingchang Li,

Toshiaki Yoshioka, Yohei Yamamoto and Katsuhiko Enomoto

**Signaling Axis and HIF-1 in Hepatocellular Carcinoma 253** 

Chapter 9 **Chemically Induced Hepatocellular Carcinoma and Stages of** 

**Development with Biochemical and Genetic Modulation: A Special Reference to Insulin-Like-Growth Factor II** 

Chapter 8 **Proteoglycans in Chronic Liver Disease and** 

Péter Tátrai and Ilona Kovalszky

**and Raf Gene Signaling 201**  Biswajit Mukherjee, Miltu Kumar Ghosh and Chowdhury Mobaswar Hossain

Ying Chen and Qingzhong Kong

Ilias Mylonis and George Simos

Chapter 13 **Gap Junction Intercellular Communication and** 

**Cells and Hepatocarcinoma 275** 

Chapter 14 **Mechanisms of HBx Mediated Liver Cancer:** 

Chapter 11 **Cytoplasmic Connexin32 and Self-Renewal of** 

Chapter 12 **The Involvement of the ERK-Hypoxia-Angiogenesis**

**Connexin Expression Profile in Normal Liver** 

Glaucia M. Machado-Santelli and Marisa Ionta

**Multiple Pathways and Opportunities 287**  Mark A. Feitelson, Alla Arzumanyan, Tiffany Friedman, N. Lale Tufan, Zhaorui Lian, Marcia M. Clayton, Joyce Kang,

**Pathway During Hepatic Carcinogenesis 313** 

**Circulating Tumor Cells (CTC) Measurements 327**

Helena M. G. P. V. Reis, Jingbo Pan, Jie Liu, Patrick Arbuthnot and Michael Kew

Chapter 15 **Molecular Mechanism of DNA Damage Response** 

Yasunobu Matsuda and Toshifumi Wakai

**Part 3 Detection / Prevention / Prevalence 325**

Natalia Olaya and Franck Chiappini

Chapter 16 **Hepatocellular Carcinoma: Methods of** 

Chapter 10 **Hepatocellular Carcinoma: Insights** 

**and Invasion of Hepatocellular Carcinoma Cells and is Inactivated in Human Hepatocellular Carcinoma 161**

> Chapter 18 **Reviews on the Epidemiology, Quality of Life, and Management of Chronic Hepatitis B (CHB) 373**  Elegance T.P. Lam and Cindy L.K. Lam

Preface

Clinical Research.

book useful.

Hepatocellular Carcinoma represents a leading cause of cancer death and a major health problem in developing countries. It has also become increasingly important

Knowledge of hepatocellular carcinoma has progressed rapidly. This book is a compendium of papers written by experts to present the most up-to-date knowledge of hepatocellular carcinoma. We have decided to divide this book on Hepatocellular Carcinoma into two books because of the overwhelming number of excellent book chapters we received from scientists and clinicians from all parts of the world:- Hepatocellular Carcinoma – Basic Research, and Hepatocellular Carcinoma –

Hepatocellular Carcinoma – Basic Research is divided into three sections: (I) Biomarkers / Therapeutic Target; (II) Carcinogenesis / Invasion / Metastasis; and (III)

This book is an important contribution to the field of hepatocellular carcinoma with an emphasis on basic research. The intended readers of this book are scientists and clinicians who are interested in research on hepatocellular carcinoma. Epidemiologists, pathologists, hospital administrators and drug manufacturers will also find this

Department of Surgery, The Chinese University of Hong Kong,

Prince of Wales Hospital, Hong Kong SAR,

**Dr. Wan-Yee Lau** 

China

Detection / Prevention / Prevalence. There are 18 chapters in this book.

with the increase in hepatitis C infection in developed countries.
