**1.3.3 Experimental liver cancer in animals**

Cancer in general is a multistage complex process by which uncontrolled proliferation of cells occurs. To understand the underlying mechanism in the process of development of the disease and its progress, it is important to develop the strategy to combat the dreadful disease. The need for the development of various in vivo cancer models has been in demand. Experimental liver cancer in animals is thus developed for studying the progress of the disease scientifically minutely in vivo and to develop therapeutic and other combating strategies to fight against it. There are various in vivo animal models already available for the purpose. Generally, virus-induced, radiation-induced, neoplastic cell-transplanted and chemical-induced liver cancer animal models have been widely studied.
