Contents

#### **Preface XIII**

	- **Part 2 Regulation of Hematopoietic Stem Cells 89**

X Contents


Contents VII

Chapter 19 **Bone Marrow Derived Pluripotent** 

Chapter 20 **Gene Therapy of Hematopoietic and** 

**Stem Cells in Ischemic Heart Disease: Bridging the** 

**Immune Systems: Current State and Perspectives 441** Maria Savvateeva, Fedor Rozov and Alexander Belyavsky

**Gap Between Basic Research and Clinical Applications 425**  Ahmed Abdel-Latif, Ewa Zuba-Surma and Mariusz Z. Ratajczak

Chapter 19 **Bone Marrow Derived Pluripotent Stem Cells in Ischemic Heart Disease: Bridging the Gap Between Basic Research and Clinical Applications 425**  Ahmed Abdel-Latif, Ewa Zuba-Surma and Mariusz Z. Ratajczak

VI Contents

Chapter 8 **Skeletogenesis and the Hematopoietic Niche 147**  Elizabeth Sweeney and Olena Jacenko

Aysegul Ocal Sahin and Miranda Buitenhuis

**Expand Hematopoietic Stem Cells 205** 

Philippe Leboulch and Diana Tronik-Le Roux

**Part 3 Hematopoietic Stem Cells in Aging and Disease 245** 

**Acute Myeloid Leukemia Development 261** Sérgio Paulo Bydlowski and Felipe de Lara Janz

**Normal and Malignant Hematopoiesis 277** 

Chapter 14 **Distribution of SDF1-3'A, GNB3 C825T and MMP-9 C-1562T** 

**Emerging Effector Cells in Fibrotic Disorders 317** Carolina García-de-Alba, Moisés Selman and Annie Pardo

Chapter 16 **Hematopoietic Stem Cells Therapeutic Applications 347** 

**Cellular Therapeutic Transplantation 383** Karen M. Hall, Holli Harper and Ivan N. Rich

**Allogeneic SCT Recipients: The Multiple Assays 407**

Omar J. BenMarzouk-Hidalgo and Pilar Pérez-Romero

**Polymorphisms in HSC CD34+ from Peripheral Blood of Patients with Hematological Malignancies 299** 

Rosana Pelayo, Elisa Dorantes-Acosta, Eduardo Vadillo and Ezequiel Fuentes-Pananá

Ben Nasr Moufida and Jenhani Faouzi

**Part 4 Hematopoietic Stem Cell Therapy 345** 

A. Herrera-Merchan, I. Hidalgo, L. Arranz and S. Gonzalez

Jeanne Grosselin, Karine Sii-Felice,

Chapter 11 **Insights Into Stem Cell Aging 247** 

Chapter 12 **Hematopoietic Stem Cell in** 

Chapter 13 **From HSC to B-Lymphoid Cells in**

Chapter 15 **Hematopoietic Derived Fibrocytes:** 

Chapter 17 **Hematopoietic Stem Cell Potency for** 

Carla McCrave

Chapter 18 **Detection of CMV Infection in**

Pilar Blanco-Lobo,

**Marrow Homing of Hematopoietic Stem Cells 185** 

Chapter 9 **Molecular Mechanisms Underlying Bone**

Chapter 10 **Searching for the Key to**

Chapter 20 **Gene Therapy of Hematopoietic and Immune Systems: Current State and Perspectives 441**  Maria Savvateeva, Fedor Rozov and Alexander Belyavsky

Preface

therapy.

The prospective isolation of primitive blood-forming cells along with depicting of transcriptional networks that control early cell fate decisions, and characterization of microenvironmental signals influencing differentiation pathways during normal hematopoiesis, have been critical to the construction of a hierarchical model for the hematopoietic development, that has served as a paradigm for a number of systems within vertebrate development. Hematopoietic stem cell research has been helpful to elucidate mechanisms that govern tissue regeneration, to give an insight into perspectives that may allow protection of the system during disease, to design lifesaving therapies, and to discover novel drug activities. This promising field is being accelerated by significant contributions in genomics, molecular biology, and technologies including fluorescent activated cell sorting and mouse engineering, that

This book, *Advances in Hematopoietic Stem Cell Research,* is devoted to current and inprogress scientific knowledge on basic aspects of these seminal cells and their therapeutic applications. The text consists of 20 chapters grouped into four sections: 1) Hematopoietic stem cell properties, 2) Regulation of hematopoietic stem cells, 3) Hematopoietic stem cells in aging and disease, and 4) Hematopoietic stem cell

The first section provides four comprehensive chapters on the functional characteristics and biological properties that make distinctive the conspicuous population of hematopoietic stem cells, including multipotency, self-renewal, quiescence and novel surface markers. Five chapters in the second section contain powerful information about intrinsic and extrinsic factors that determine cell fates in early development. The authors have discussed cellular and molecular aspects of the hematopoietic microenvironment within the bone marrow, and progress in searching of procedures to make the expansion of truly stem cells possible . Behavior of the stem and progenitor cells in aging and during disease is analyzed in the third section of this text, which highlights recent achievements in unraveling the role of primitive cells in

Finally, to provide a comprehensive overview of the advancements in therapeutic applications of hematopoietic stem cells, a fourth section with five chapters addresses

give us a more integrated view of the nature of stem cells .

the pathogenesis of hematological malignancies like leukemia.
