**Meet the editor**

Dr David Mathieu MD., FRCS(C) is an associate professor at the Université de Sherbrooke within the Departments of Surgery, Division of Neurosurgery, and Nuclear Medicine and Radiobiology in addition to holding the post of director of the Neurosurgery Division and of the Gamma Knife Radiosurgery department at the Centre Hospitalier Universitaire de Sherbrooke (CHUS). His

areas of expertise include neuro-oncology and stereotactic and functional neurosurgery. He is the author of many peer-reviewed articles on these topics and serves on the board of directors of the North American Gamma Knife Consortium (NAGKC), a research organization dedicated to the development of multicentric Gamma Knife Radiosurgery trials. Dr Mathieu is in charge of clinical research in neuro-oncology at the CHUS and has numerous research collaborations with members of the Neuroscience Center and the Radiotherapy Research Center of the Université de Sherbrooke.

Contents

**Preface IX** 

**Part 1 Neoplastic Disorders 1** 

Chapter 2 **Gamma Knife Treatment** 

Chapter 3 **Radiosurgical Treatment of** 

**Update 2011. 45** 

Chapter 5 **Gamma Knife Radiosurgery in** 

P. Mirtuono and M. Gerosa

and Veronica L.S. Chiang

José Lorenzoni, Adrián Zárate, Raúl de Ramón, Leonardo Badínez, Francisco Bova and Claudio Lühr

**Intracranial Meningiomas:** 

Chapter 1 **Outcomes Following Gamma Knife for Metastases 3**  Henry S. Park, James B. Yu, Jonathan P.S. Knisely

**for Patient Harboring Brain Metastases:** 

M. Gerosa, R. Foroni, M. Longhi, A. De Simone,

Chapter 4 **Gamma Knife Radiosurgery for the Vestibular Schwannomas, Technical Considerations and Hydrocephalus as a Complication 59** 

**the Management of Unusual Grade I/II** 

**Primitive Neuroepithelial Tumours of the Brain 73**  A. Nicolato, M. Longhi, R. Foroni, F. Alessandrini, A. De Simone, C. Ghimenton, A. De Carlo,

Sung Kyoo Hwang, Kisoo Park, Dong Hyun Lee, Seong Hyun Park, Jaechan Park and Jeong Hyun Hwang

F. Alessandrini, P. Meneghelli, B. Bonetti, C. Ghimenton, T. Sava, S. Dall'Oglio, A. Talacchi, C. Cavedon, F. Sala, R. Damante, F. Pioli, S. Maluta and A. Nicolato

**How to Estimate Patient Eligibility and Survival? 29** 

## Contents

## **Preface XI**

## **Part 1 Neoplastic Disorders 1**  Chapter 1 **Outcomes Following Gamma Knife for Metastases 3**  Henry S. Park, James B. Yu, Jonathan P.S. Knisely and Veronica L.S. Chiang Chapter 2 **Gamma Knife Treatment for Patient Harboring Brain Metastases: How to Estimate Patient Eligibility and Survival? 29**  José Lorenzoni, Adrián Zárate, Raúl de Ramón, Leonardo Badínez, Francisco Bova and Claudio Lühr Chapter 3 **Radiosurgical Treatment of Intracranial Meningiomas: Update 2011. 45**  M. Gerosa, R. Foroni, M. Longhi, A. De Simone, F. Alessandrini, P. Meneghelli, B. Bonetti, C. Ghimenton, T. Sava, S. Dall'Oglio, A. Talacchi, C. Cavedon, F. Sala, R. Damante, F. Pioli, S. Maluta and A. Nicolato Chapter 4 **Gamma Knife Radiosurgery for the Vestibular Schwannomas, Technical Considerations and Hydrocephalus as a Complication 59**  Sung Kyoo Hwang, Kisoo Park, Dong Hyun Lee, Seong Hyun Park, Jaechan Park and Jeong Hyun Hwang Chapter 5 **Gamma Knife Radiosurgery in the Management of Unusual Grade I/II Primitive Neuroepithelial Tumours of the Brain 73**  A. Nicolato, M. Longhi, R. Foroni, F. Alessandrini,

A. De Simone, C. Ghimenton, A. De Carlo,

P. Mirtuono and M. Gerosa

#### X Contents

## **Part 2 Functional and Vascular Disorders 101**

Chapter 6 **Clinical, Anatomo-Radiological and Dosimetric Features Influencing Pain Outcome After Gamma Knife Treatment of Trigeminal Neuralgia 103**  José Lorenzoni, Adrián Zárate, Raúl de Ramón, Leonardo Badínez, Francisco Bova and Claudio Lühr

## Chapter 7 **Advanced Gamma Knife Treatment Planning of Epilepsy 123**  Andrew Hwang and Lijun Ma

Chapter 8 **Hemorrhage from Arteriovenous Malformation Following Gamma Knife Radiosurgery: Pathophysiology of Rupture Early in the Latency Period 133**  Juanita M. Celix, James G. Douglas and Robert Goodkin

## **Part 3 Basic Science 155**

Chapter 9 **Applications of Gamma Knife Radiosurgery for Experimental Investigations in Small Animal Models 157**  Gabriel Charest, Benoit Paquette and David Mathieu

## Preface

In the past 25 years, gamma knife radiosurgery has evolved from a tool that was seen as a curiosity to a minimally-invasive neurosurgical treatment modality that is now a recognized alternative to conventional microsurgery or fractionated radiation therapy. Radiosurgery training is now implemented in most neurosurgical residency training program. The literature on the subjected has exploded in the past few years, with literally hundreds of papers being published annually on this topic.

As physicians and patients become increasingly aware of the benefits of gamma knife radiosurgery, it is important that information is readily available when it is needed. That is the purpose of this book, which covers some of the most common indications for which gamma knife radiosurgery is performed.

The first section of the book is dedicated to tumor radiosurgery. Brain metastases are now the most common tumors treated by gamma knife radiosurgery. Two chapters are devoted to this topic. Other chapters report the treatment results for meningiomas and vestibular schwannomas, the most frequent benign intracranial tumors treated by radiosurgery, and another is devoted to the treatment of rarer tumors. The second section covers benign non tumoral indications of radiosurgery, with chapters devoted to trigeminal neuralgia, epilepsy, and arteriovenous malformations. Finally, the last chapter reports on the use of the gamma knife as a tool for preclinical research.

I hope that the information provided in the book will improve the knowledge on the many applications and uses of gamma knife radiosurgery, and allow more patients worldwide to benefit from this treatment modality when appropriate.

**David Mathieu, M.D., F.R.C.S.(C)** 

University of Sherbrooke, Faculty of Medicine and Health Sciences, Department of Surgery, Division of Neurosurgery, Department of Nuclear Medicine and Radiobiology, Sherbrooke, Quebec, Canada

**Part 1** 

**Neoplastic Disorders** 
