**Acknowledgements**

The authors gratefully thank Prof Dr. Francis Levi from Warwick University (UK) for constructive discussions all along the process of this work and for reviews on some chapters. Muriel Focan (Chief Officer Bank of New York, Brussels, Belgium), for reviewing English formulation, and Audrey Stultiens (Clinical Research, Oncology Department, CHC-Liège), for actualizing figures, are also warmly acknowledged.
