**Section 5** Chronobiology of the Respiratory System **71 Chapter 6 73** Integration of Chronobiological Concepts for NSCLC Management *by Christian Focan, Anne-Catherine Davin, Maryam Bourhaba and Marie-Pascale Graas*

Preface

A general view of the importance of chronobiology can be seen in the chapter"Time structure of the functional organization of living systems" by Mohammad Rayees Dar and Abdul Roof Rather. The authors describe the reality that there is a temporal biological system in living organisms that controls, synchronizes, and coordinates all body systems to external rhythmic changes. The authors present examples from everyday physiology and clinical medicine, where rhythmic phenomena can be encountered, as well as the meaning, perspectives, and representation of chronobiology in all scientific biological disciplines. More detailed issues of control of circadian rhythms are discussed in the chapter"Light-dependent regulation of circadian clocks in vertebrates" by Junko et al., where the authors analyze cellularclock regulation in mammals and point out the specifics of cellular-clock regulation in zebrafish (direct synchronization of peripheral cellular clocks in addition to

In the cardiovascular system, practically all measurable functions exhibit circadian oscillations. The importance of dosing of antihypertensive drugs over time is receiving increased attention. The authors Narsingh Verma et al. in the chapter "Blood pressure variability and its clinical implications" discuss this problem in more detail and point to the fact that this type of therapy may be important because of the greater incidence of cardiovascular events in the early morning hours, in association with increases in blood pressure, heart rate, cardiac ischemia, enhanced platelet aggregability, and plasma catecholamines. Also important are the facts about dippers and nondippers and their relationship to other cardiovascular diseases whose predominance is in the early morning hours. The clinical physiology of children and older people refers to the differences that arise during ontogenesis in the endocrine system that in turn affects physiological functions. The authors Sheveleva et al. in the chapter "Circadian rhythm of blood pressure in children and adolescents" express the idea that formation of the circadian organization of the vegetative mechanisms that underlie the formation of daily arterial pressure profile

Jarczok et al. in "Circadian rhythms of the autonomic nervous system—scientific implication and practical implementation" discuss the practical application of circadian heart rate variability (HRV) patterns, for example, at different risk states and diseases, including depression, where reduced HRV parameters and circadian rhythm disorders have been reported. The inflammatory reflex is a physiological mechanism through which the vagus nerve regulates immune function. In the chapter, there are a few examples confirming that 24-hour measurement of HRV may be a practical tool in prevention. This statement is supported by examples with intact chronobiology and then examples with clear disorders. Finally, it is emphasized

Chronobiology is the science investigating and objectively quantifying the mechanisms of the biological time structure, including the rhythmic manifestations of life. The disturbance of the temporal structure of the living organism leads to disturbed harmony between biological rhythms and the rhythm of the external

environment often resulting in a cyclic course of various diseases.

central cellular clocks by light).

probably depend on age.
