**9.2 Echinomycin**

Several studies have proved that both echinomycin quinoxaline rings bisintercalate into DNA, with CG selectivity, while the inner part of the depsipeptide establishes H-bonds with the DNA bases of the minor groove region of the two base pairs comprised between the chromophores (**Figure 9**) [8].

**Figure 8.** *Schematic interaction between DNA and mitomycin-C.*

**Figure 9.** *Schematic interaction between DNA and echinomycin.*
