**10. Conclusions**

NB cell lines can be categorized into three groups by the patterns of IGF-1R/ Akt pathway response. PPP, MK2206, and AZD8055 showed significant antitumor effect in NB cells. Our current results highlight the potential of IGF-1R/PI3K/ Akt/mTOR pathway as a promising target for NB treatment. PPP, MK2206, and AZD8055 should be further investigated for NB treatment in clinical trials.

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**Author details**

Tsu, Mie, Japan

provided the original work is properly cited.

*Molecular Target Therapy against Neuroblastoma DOI: http://dx.doi.org/10.5772/intechopen.81706*

© 2018 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/3.0), which permits unrestricted use, distribution, and reproduction in any medium,

Hidemi Toyoda\*, Dong-Qing Xu, Lei Qi and Masahiro Hirayama

\*Address all correspondence to: htoyoda@clin.medic.mie-u.ac.jp

Department of Pediatrics, Mie University Graduate School of Medicine,
