**2.2 Statistics**


Pared t-*t*ests were used to analyze in each size change from baseline. Statitstical significance was defined as *P* < 0.05.

Table 1. Myoma volume change during sequential treatment with GnRHa and dienogest

The patients were sequentially treated with leuprolide acetate (1.88mg monthly) for 6 months and dienogest (2mg daily) for 6months. Measurements of nodes using MRI were performed at baseline, during treatment at months 6 (after GnRHa therapy) and 12 (after dienogest therapy).
