**2.1 Reproductive chart review**

The data were collected from 13 perimenopausal patients sequentially treated with leuprolide acetate (1.88mg monthly, Takeda Pharmaceutical, Japan) for 6 months and dienogest (2mg/day, Mochida Pharmaceutical, Japan) for 6 months against endometriosis in our patient clinic from January 2008 to May 2011. In this retrospective chart review, we included all perimenopausal patients complicated with a myoma node measuring > 4cm or with adenomyosis measuring >10 cm at the age 46-52 years. Measurements of nodes or total uterine volume using MRI were performed at baseline and during treatment at months 6 and 12. For tecknical reasons, leuprolide acetate was supplied in vials and dienogest in tablets.

Size of myoma or overall uterine was measured at three diameters (transverse, vertical and anterior-posterior) with MRI. Half of multiplied three diameters was accepted as size of myomas and uterus. These measurements were repeated 6 and 12 months after starting the therapy.
