**5. Immune response in peritoneal cavity in endometriosis**

As we can see from our results and from number of literature data, behavior of endometrial cells, floating in peritoneal fluid, is directly regulated by the peritoneal fluid microenvironment. Deficiency of immune response in peritoneal cavity supposedly might prevent clearance of the retrograde menstrual debris from the peritoneal environment and permits the implantation of misplaced endometrial cells that result in the development of endometriosis (Dmowski & Braun, 2004). To define more precisely the mechanisms attributing to the impairment of immune response in peritoneal fluid, we have studied the functional state of peritoneal macrophages and peritoneal fluid cytokine profile in endometriosis.
