**7. Summary**

We have reviewed various studies with regard to the understanding of pathomechanism of infertility in endometriosis, based on its impacts on number of pathologic conditions, such as: pelvic adhesion and endometrioma, abnormal folliculogenesis and impaired oocyte function, altered sperm function, reduced embryo quality, and impaired endometrium receptivity. The controversy regarding whether endometriosis is a cause of infertility or an incidental finding is ongoing.

Based on several studies reviewed above showed that peritoneal microenvironment of women with endometriosis which contain pro-inflammatory factor and ROS is the main causative factor of the pathomechanism of infertility in endometriosis. They have a key role through autocrine-paracrine communication alteration in the mechanism of pelvic adhesion, abnormal folliculogenesis, reduced oocyte/embryo quality, reduced sperm fuction and implantaion impairment (see figure 2). We hope that the increase of our understanding on the above pathomechanism can increase our attention to the improvement of the complex management of infertility in endometriosis.

### **8. Acknowledgments**

The author would like to thank Prof Lila Dewata and Prof Samsulhadi for their assistance in the preparation of the manuscript.

#### **9. References**

350 Endometriosis - Basic Concepts and Current Research Trends

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Endometrial aspects and molecular studies on the receptivity status of endometrium resulted in conflicting data. Several studies suggest that an altered follicular microenvironment could be responsible for a defective folliculogenesis, and subsequently reduced oocyte/embryo quality, and in turn, result in altered embryo implantation but the

Fig. 2. Pathomechanism of infertility in endometriosis (Hendarto, 2011)

We have reviewed various studies with regard to the understanding of pathomechanism of infertility in endometriosis, based on its impacts on number of pathologic conditions, such as: pelvic adhesion and endometrioma, abnormal folliculogenesis and impaired oocyte function, altered sperm function, reduced embryo quality, and impaired endometrium receptivity. The controversy regarding whether endometriosis is a cause of infertility or an

2001).

**7. Summary** 

incidental finding is ongoing.

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**19** 

*China* 

*Xinjiang Medical University,* 

**Analysis of Differential Genes of Uyghur Women with Endometriosis in Xinjiang** 

Aixingzi Aili, Ding Yan, Hu Wenjing, Yang Xinhua and Hanikezi Tuerxun

Endometriosis (EM) is a common and important health problem, it is estimated to be present in 10%-15% of women in the reproductive age group and 25%-35% of infertile women. In the First Affiliated Hospital of Xinjiang Medical University in China, 447 cases primaily diagnosed with surgically confirmed endometriosis between January 2000 to September 2005, among them 349 cases of endometriosis were Han Chinese (78.1%) and 69

Xinjiang is the biggest province of China inhabited by ethnic minorities in which Uyghur people are accounted for more than 40% of the total population. In recent years, the number of the Uyghur women with endometriosis have been increased in Xinjiang, however still clearly less than Han chinese with endometriosis. The data from pathology deparment of the First Affiliated Hospital of Xinjiang Medical University between 1992 and 1996 showed that there were only three Uyghur women with endometriosis (5.76%) among 52 cases. Between 2000 and 2001, only 4 Uyghur women with endometriosis (3.1%) among 128 patients. Between 2003 and 2010, there were 73 Uyghur women (13.45%) with endometriosis

**1. Introduction** 

Fig. 1.

cases Uyghur women with endometriosis (15.3%).

