**6.6. Leukemia**

An bilberry extract (Antho 50) was used to determine its effect on Jurkat cells. The main interest of this study is the result of Antho 50 on certain proteins, polycomb group (PcG), which are epigenetic regulators. These proteins reduce the expression of suppressor tumor genes, promoting the survival of tumor cells [81]. The aim is to see if the extract is able to inhibit these PcG proteins. The extract was able to downregulate the PcG and related proteins and induces apoptosis. All these events have an effect on the intracellular ROS formation, causing an increase, resulting in the death of tumor cells [82]. In another study, delphinidin and cyanidin, two major compounds in *Hibiscus sabdariffa*, were investigated. They are able to induce cell cycle arrest in human leukemia cell line HL-60. This effect occurs because of their action on signaling pathways whose role is to induce cell cycle arrest. This indicates promising anticarcinogenic effects [83].
