**Acknowledgements**

This project was supported by the Basque Country Government (Department of Education, University and Research, predoctoral grant PRE\_2016\_2\_0302 and Consolidated Groups, IT907- 16) and by the University of Basque Country UPV/EHU (predoctoral grant PIF17/79). Authors wish to thank the intellectual and technical assistance from the ICTS "NANBIOSIS," more specifically by the Drug Formulation Unit (U10) of the CIBER in Bioengineering, Biomaterials, and Nanomedicine (CIBER-BBN) at the University of the Basque Country (UPV/EHU).
